Acute effects of hemodialysis on nitrite and nitrate: potential cardiovascular implications in dialysis patients

Bryan, Nathan S.; Torregrossa, Ashley C.; Mian, Afsar; Berkson, D. Lindsey; Westby, Christian M.; Moncrief, Jack W.

doi:10.1016/j.freeradbiomed.2013.01.020

Cited by 23 publications

(18 citation statements)

References 35 publications

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“…The mechanisms contributing to increased morbidity and mortality are probably multifactorial. In both adults and paediatric patients, repeated dialysis lowers circulating levels of nitrate and nitrite, as well as marker of NO signalling (ie, cGMP), which is associated with increased blood pressure and increased incidence of ischaemic stroke . Based on these findings, the authors proposed that supplementation with inorganic nitrate may prevent dialysis‐mediated NO deficiency, thus reduce the risk of having adverse cardiovascular complications during chronic dialysis.…”

Section: Organ Systems Involved In the Blood Pressure Reduction By Inmentioning

confidence: 99%

Mechanisms underlying blood pressure reduction by dietary inorganic nitrate

2018

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Nitric oxide (NO) importantly contributes to cardiovascular homeostasis by regulating blood flow and maintaining endothelial integrity. Conversely, reduced NO bioavailability is a central feature during natural ageing and in many cardiovascular disorders, including hypertension. The inorganic anions nitrate and nitrite are endogenously formed after oxidation of NO synthase (NOS)-derived NO and are also present in our daily diet. Knowledge accumulated over the past two decades has demonstrated that these anions can be recycled back to NO and other bioactive nitrogen oxides via serial reductions that involve oral commensal bacteria and various enzymatic systems. Intake of inorganic nitrate, which is predominantly found in green leafy vegetables and beets, has a variety of favourable cardiovascular effects. As hypertension is a major risk factor of morbidity and mortality worldwide, much attention has been paid to the blood pressure reducing effect of inorganic nitrate. Here, we describe how dietary nitrate, via stimulation of the nitrate-nitrite-NO pathway, affects various organ systems and discuss underlying mechanisms that may contribute to the observed blood pressure-lowering effect.

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Section: Organ Systems Involved In the Blood Pressure Reduction By Inmentioning

confidence: 99%

Mechanisms underlying blood pressure reduction by dietary inorganic nitrate

2018

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“…It serves as an important substrate for nitrite and NO production. Recently we realized that patients with end-stage renal disease on hemodialysis cannot clear nitrate but is removed through the hemodialysis process [44].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Inorganic nitrite and nitrate: evidence to support consideration as dietary nutrients

2015

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“…Furthermore, circulating and salivary levels of nitrite increase after a nitrate load [3] and eradication of oral bacteria cause a decrease in salivary nitrite and an increase in blood pressure [17]. To the contrary, as NO production/availability is decreased, both plasma and salivary levels of nitrite decline [23]. So whether there is sufficient NO produced by the vascular endothelium from eNOS to form nitrite and nitrate in the circulation which is then concentrated in our salivary glands or there is sufficient nitrate ingested in the diet and then subsequently reduced to nitrite, this will be reflected as nitrite in the saliva.…”

Section: Salivary Nitrite As a Marker Of Systemic No Availabilitymentioning

confidence: 99%