Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation

Cantow, Kathleen; Pohlmann, Andreas; Flemming, Bert; Ferrara, Fabienne; Waiczies, Sonia; Grosenick, Dirk; Niendorf, Thoralf; Seeliger, Erdmann

doi:10.1038/srep29965

Cited by 12 publications

(30 citation statements)

References 37 publications

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“…A recent report studied acute intrinsic effects of ferumoxytol on the control of renal haemodynamics and oxygenation in rats . This study was of high relevance as basic methodological principles require that a method intended to measure a certain variable per se does not alter this variable.…”

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

“…This study was of high relevance as basic methodological principles require that a method intended to measure a certain variable per se does not alter this variable. For this purpose, in vivo measurements of arterial blood pressure, total renal blood flow (RBF, transsonic probe), local perfusion (laser‐Doppler‐flux) and tissue pO 2 (fluorescence quenching optodes) in the renal cortex and medulla of healthy rats were employed upon application of ferumoxytol . Modulation of renal haemodynamics and oxygenation was accomplished by dedicated test interventions .…”

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

“…For this purpose, in vivo measurements of arterial blood pressure, total renal blood flow (RBF, transsonic probe), local perfusion (laser‐Doppler‐flux) and tissue pO 2 (fluorescence quenching optodes) in the renal cortex and medulla of healthy rats were employed upon application of ferumoxytol . Modulation of renal haemodynamics and oxygenation was accomplished by dedicated test interventions . The dose study included three (cumulative) doses of ferumoxytol: two low doses adapted from previous reports on monitoring the blood volume fraction of the brain and kidneys in rats, and a high‐dose regimen that mimics the human equivalent dose (based upon body surface area) for the therapeutic application of ferumoxytol .…”

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

“…The results demonstrated no immediate risk of impaired control of renal oxygenation or perfusion upon application of ferumoxytol. This observation rendered ferumoxytol as an intravascular contrast medium suitable for the quantification and monitoring of changes in renal blood volume fraction …”

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

“…A recent report studied acute intrinsic effects of ferumoxytol on the control of renal haemodynamics and oxygenation in rats. 63 This study was of high relevance as basic methodological principles require that a method intended to measure a certain variable per se does not alter this variable. For this purpose, in vivo measurements of arterial blood pressure, total renal blood flow (RBF, transsonic probe), local perfusion (laser-Doppler-flux) and tissue pO 2 (fluorescence quenching optodes) in the renal cortex and medulla of healthy rats were employed upon application of ferumoxytol.…”

Section: Not Affect Regulation Of Renal Haemodynamics and Oxygenationmentioning

confidence: 99%

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Probing renal blood volume with magnetic resonance imaging

et al. 2020

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Damage to the kidney substantially reduces life expectancy. Renal tissue hypoperfusion and hypoxia are key elements in the pathophysiology of acute kidney injury and its progression to chronic kidney disease. In vivo assessment of renal haemodynamics and tissue oxygenation remains a challenge. Blood oxygenation level–dependent (BOLD) magnetic resonance imaging (MRI) is sensitive to changes in the effective transversal relaxation time (T2*) in vivo, and is non‐invasive and indicative of renal tissue oxygenation. However, the renal T2* to tissue pO2 relationship is not governed exclusively by renal blood oxygenation, but is affected by physiological confounders with alterations in renal blood volume fraction (BVf) being of particular relevance. To decipher this interference probing renal BVf is essential for the pursuit of renal MR oximetry. Superparamagnetic iron oxide nanoparticle (USPIO) preparations can be used as MRI visible blood pool markers for detailing alterations in BVf. This review promotes the opportunities of MRI‐based assessment of renal BVf. Following an outline on the specifics of renal oxygenation and perfusion, changes in renal BVf upon interventions and their potential impact on renal T2* are discussed. We also describe the basic principles of renal BVf assessment using ferumoxytol‐enhanced MRI in the equilibrium concentration regimen. We demonstrate that ferumoxytol does not alter control of renal haemodynamics and oxygenation. Preclinical applications of ferumoxytol enhanced renal MRI as well as considerations for its clinical implementation for examining renal BVf changes are provided alongside practical considerations. Finally, we explore the future directions of MRI‐based assessment of renal BVf.

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Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

Section: Ferumoxytol Does Not Affect Regulation Of Renal Haemodynamicmentioning

confidence: 99%

Section: Not Affect Regulation Of Renal Haemodynamics and Oxygenationmentioning

confidence: 99%

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Probing renal blood volume with magnetic resonance imaging

et al. 2020

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Renal perfusion imaging by MRI

Zhang

Lee

2019

Magnetic Resonance Imaging

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Renal perfusion can be quantitatively assessed by multiple magnetic resonance imaging (MRI) methods, including dynamic contrast enhanced (DCE), arterial spin labeling (ASL), and diffusion‐weighted imaging with intravoxel incoherent motion (IVIM) analysis. In this review we summarize the advances in the field of renal‐perfusion MRI over the past 5 years. The review starts with a brief introduction of relevant MRI methods, followed by a discussion of recent technical developments. In the main section of the review, we examine the clinical and preclinical applications for three disease populations: chronic kidney disease, renal transplant, and renal tumors. The DCE method has been routinely used for assessing renal tumors but not other renal diseases. As a noncontrast alternative, ASL was extensively explored in both preclinical and clinical applications and showed much promise. Protocol standardization for the methods is desperately needed, and then large‐scale clinical trials for the methods can be initiated prior to their broad clinical use.Level of Evidence: 5Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2019. J. Magn. Reson. Imaging 2020;52:369–379.

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Dynamic parametric MRI and deep learning: Unveiling renal pathophysiology through accurate kidney size quantification

Klein,

Gladytz,

Millward

et al. 2023

NMR in Biomedicine

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Renal pathologies often manifest as alterations in kidney size, providing a valuable avenue for employing dynamic parametric MRI as a means to derive kidney size measurements for the diagnosis, treatment, and monitoring of renal disease. Furthermore, this approach holds significant potential in supporting MRI data‐driven preclinical investigations into the intricate mechanisms underlying renal pathophysiology. The integration of deep learning algorithms is crucial in achieving rapid and precise segmentation of the kidney from temporally resolved parametric MRI, facilitating the use of kidney size as a meaningful (pre)clinical biomarker for renal disease. To explore this potential, we employed dynamic parametric T2 mapping of the kidney in rats in conjunction with a custom‐tailored deep dilated U‐Net (DDU‐Net) architecture. The architecture was trained, validated, and tested on manually segmented ground truth kidney data, with benchmarking against an analytical segmentation model and a self‐configuring no new U‐Net. Subsequently, we applied our approach to in vivo longitudinal MRI data, incorporating interventions that emulate clinically relevant scenarios in rats. Our approach achieved high performance metrics, including a Dice coefficient of 0.98, coefficient of determination of 0.92, and a mean absolute percentage error of 1.1% compared with ground truth. The DDU‐Net enabled automated and accurate quantification of acute changes in kidney size, such as aortic occlusion (−8% ± 1%), venous occlusion (5% ± 1%), furosemide administration (2% ± 1%), hypoxemia (−2% ± 1%), and contrast agent‐induced acute kidney injury (11% ± 1%). This approach can potentially be instrumental for the development of dynamic parametric MRI‐based tools for kidney disorders, offering unparalleled insights into renal pathophysiology.

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Acute effects of ferumoxytol on regulation of renal hemodynamics and oxygenation

Cited by 12 publications

References 37 publications

Probing renal blood volume with magnetic resonance imaging

Probing renal blood volume with magnetic resonance imaging

Renal perfusion imaging by MRI

Dynamic parametric MRI and deep learning: Unveiling renal pathophysiology through accurate kidney size quantification

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