Acute edematous and necrotic pancreatitis in a porcine model

Meriläinen, Sanna; Mäkelä, Jyrki; Anttila, Vesa; Koivukangas, Vesa; Kaakinen, Hanna; Niemelä, Eija; Ohtonen, Pasi; Risteli, Juha; Karttunen, Tuomo J.; Soini, Ylermi; Juvonen, Tatu

doi:10.1080/00365520802158580

Cited by 21 publications

(12 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CLDN2 promoter includes an NFκB binding site 19 , and gene expression is enhanced in other cells under conditions associated with injury or stress 20-22 . Claudin-2 can also be expressed by acinar cells when stressed, as reported in porcine models of acute pancreatitis 23 . Other genes within the CLND2 locus include MORC4, RIPPLY1 , and TBC1D8B .…”

mentioning

confidence: 71%

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Whitcomb¹,

LaRusch²,

Krasinskas³

et al. 2012

Nat Genet

309

281

View full text Add to dashboard Cite

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR, and SPINK1 variants were associated with pancreatitis risk. We now report two significant genome-wide associations identified and replicated at PRSS1-PRSS2 (1×10-12) and x-linked CLDN2 (p < 1×10-21) through a two-stage genome-wide study (Stage 1, 676 cases and 4507 controls; Stage 2, 910 cases and 4170 controls). The PRSS1 variant affects susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous male) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men – male hemizygous frequency is 0.26, female homozygote is 0.07.

show abstract

mentioning

confidence: 71%

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Whitcomb¹,

LaRusch²,

Krasinskas³

et al. 2012

Nat Genet

309

281

View full text Add to dashboard Cite

show abstract

“…It was confirmed on animal models that it may be expressed during stress in the acinar cells [76]. Genetic variants in the Claudin-2 locus (CLDN2) do not increase the risk of AP and RAP, but are strongly related with an increased risk of progression of RAP to CP [13,54].…”

Section: Cldn2mentioning

confidence: 69%

Genetic determination of pancreatitis

Głuszek¹,

Kozieł²

2018

View full text Add to dashboard Cite

show abstract

“…In animal experiments, in vivo microdialysis was also used for evaluating the interstitial concentration of islet hormones and vascular permeability to proteins in the pancreas. 20,21 This raises the possibility of discovering new local biomarkers for pancreatic diseases. Moreover, this technique can be used in other organs in which needle puncturing is possible, such as the Because the inner volume of the perfusate fluid in the outlet tube (2 m) may cause a substantial time delay in sample collection, a fast perfusion rate is desirable.…”

Section: Discussionmentioning

confidence: 99%