Genetic determination of pancreatitis

Głuszek, Stanisław; Kozieł, Dorota

doi:10.5114/ms.2018.74823

Cited by 3 publications

(1 citation statement)

References 76 publications

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“…Acute pancreatitis (AP) can result in autoactivation of pancreatic enzymes and the onset of a cascade reaction that leads to pancreatic cell auto-digestion, pancreatic parenchymal necrosis, and vasculitis. Vasculitis plays a major role in triggering the inflammatory processes 1,2 which can damage blood vessels located in the peripancreatic space resulting in bleeding into the pancreas and peripancreatic tissues, as well as episodes of bleeding into the gastrointestinal tract. 3 Inflammation promotes blood clotting which, when combined with ileus and hypovolemia, can lead to thrombosis of veins near organs including splanchnic vein thrombosis (SVT).…”

Section: Introductionmentioning

confidence: 99%

Splanchnic Vein Thrombosis in Acute Pancreatitis and Its Consequences

Nawacki

Matykiewicz

Stochmal

et al. 2021

Clin Appl Thromb Hemost

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Splanchnic vein thrombosis (SVT) is a serious vascular complication that can occur in patients with acute pancreatitis. We assessed the incidence of SVT and its relationship with acute pancreatitis (AP) and associated complications. We carried out a retrospective analysis of medical histories from patients hospitalized with AP in a single surgical center. Histories were acquired from patients with abdominal and pelvic computed tomography scans performed between the 2nd and 3rd day of hospitalization. We assessed the impact and extent of thrombosis over the disease course. We found a strong positive correlation (Cramer’s V coefficient = 0.34) between SVT and disease severity. Mortality in the study group was 7.2% (8 patients) of which 5 patients (62.5%) were diagnosed with SVT. We observed an increased incidence of death among patients with thrombosis, with results approaching significance ( P = 0.056). In our study, we found that SVT has a negative effect on the course of AP and is associated with more severe disease and increased mortality.

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Section: Introductionmentioning

confidence: 99%

Splanchnic Vein Thrombosis in Acute Pancreatitis and Its Consequences

Nawacki

Matykiewicz

Stochmal

et al. 2021

Clin Appl Thromb Hemost

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The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis

Oracz

Kujko²,

Fjeld

et al. 2019

Pancreatology

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Type 2 diabetes and chronic kidney disease as important prognostic factors in acute pancreatitis

Rostropowicz-Honka

Klinger

2019

Postepy Hig Med Dosw

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This study includes an analysis of acute pancreatitis (AP) prognostic factors was performed as well as a critical review of the most important AP prognostic scales (APACHE II, Ranson, BISAP, SOFA, Marshall). The limitations of each scale were described. Simultaneously, the clinical applicability in the early prognostic AP stratification was presented, along with the clinical value of the alcoholic and gallstones etiology in the differential diagnosis. Pre-existing type 2 diabetes and chronic kidney disease significantly worsen the course of AP and should be included in the prognostic scale. It was shown that the diabetes coexisting with a HBA1C level above 6.5% significantly increases the mortality of AP patients and prolongs the period of hospitalization for 5 days. It was also observed that chronic kidney disease significantly increases the frequency of infective AP complications and raises 3-months mortality.

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Genetic determination of pancreatitis

Abstract: Pancreatitis is a complex disease with varied aetiology and clinical course. Genetic factors, in combination with environ-

Cited by 3 publications

References 76 publications

Splanchnic Vein Thrombosis in Acute Pancreatitis and Its Consequences

Splanchnic Vein Thrombosis in Acute Pancreatitis and Its Consequences

The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis

Type 2 diabetes and chronic kidney disease as important prognostic factors in acute pancreatitis

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