Acute Cystitis Symptom Score questionnaire for measuring patient-reported outcomes in women with acute uncomplicated cystitis: Clinical validation as part of a phase III trial comparing antibiotic and nonantibiotic therapy

Alidjanov, Jakhongir F; Overesch, Andre; Abramov-Sommariva, Dimitri; Hoeller, Martina; Steindl, Hubert; Wagenlehner, Florian M. E.; Naber, Kurt G.

doi:10.4111/icu.20200060

Cited by 10 publications

(8 citation statements)

References 27 publications

(44 reference statements)

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“…The limitations of our study can be summarized as the relatively small number of patients, and to be performed in a single centre. However, our results are in agreement with those found with the ACSS translated and validated in other languages as well [ 2 14 15 18 19 20 24 25 ].…”

Section: Discussionsupporting

confidence: 92%

“…Similarly, no difference was noted between pre-treatment and post-treatment severity of symptoms and leucocyte-esterase test results. The lack of significant association between levels of bacteriuria and severity of symptoms at baseline as well as for clinical outcome as found in other studies correlates with our results concerning the amount of bacteriuria [ 24 25 ].…”

Section: Discussionsupporting

confidence: 91%

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Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis

et al. 2023

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Purpose The Acute Cystitis Symptom Score (ACSS) was developed as a self-reporting questionnaire for diagnosing and monitoring acute uncomplicated cystitis (AC) in female patients. The study aims at the translation of the ACSS into Turkish from the original Uzbek including its linguistic, cognitive and clinical validation. Materials and Methods After forward and backward translation of the ACSS from Uzbek to Turkish and vice versa, the cognitive assessment of the Turkish ACSS was performed on 12 female subjects to achieve the final study version. Results The clinical validation was performed on a total of 120 female respondents including 64 Patients with AC and 56 controls without AC. For clinical diagnosis of AC, the predefined summary score of the typical symptoms of >6 showed high values (95% confidence interval) for sensitivity (0.88 [0.77–0.94]), specificity (0.98 [0.91–1.00]), and diagnostic accuracy (0.93 [0.86–0.97]). All patients were followed up between five to nine days after the baseline visit. Forty-four (68.75%) patients used antimicrobial treatment, whereas the rest (31.25%) preferred non-antimicrobial treatment. The severity scores of the typical symptoms and the quality of life were reduced significantly at follow-up. Using different (favored) thresholds for successful and non-successful treatment a clinical success rate between 54.7% and 64.1% (60.9%) was achieved. Conclusions After translation from the original Uzbek and cognitive assessment, the Turkish ACSS showed similar good results for clinical diagnosis and patient-reported outcome as in other languages validated so far and could therefore now be used for clinical studies as well as in everyday practice.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis

et al. 2023

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“…Since, according to EAU Guidelines urine analyses may lead only to a minimal increase in diagnostic accuracy in patients presenting with typical symptoms of AC, the clinical diagnosis can be made even without a point-of-care urinalysis [7]. The ACSS is a two-part self-reporting questionnaire, which has demonstrated excellent levels of reliability, validity, diagnostic and discriminative abilities in numerous studies [13,14,[39][40][41][42][43][44][45][46][47][48][49]. It contains ten items on "subjective" and one item on "objective" signs and symptoms.…”

Section: Discussionmentioning

confidence: 99%

Linguistic and clinical validation of the acute cystitis symptom score in German-speaking Swiss women with acute cystitis

et al. 2021

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Introduction and hypothesis The Global Prevalence Study of Infections in Urinary tract in Community Setting (GPIU.COM) includes epidemiological aspects of acute cystitis (AC) in women in Germany and Switzerland. The primary study relates to the German version of the Acute Cystitis Symptom Score (ACSS), a self-reporting questionnaire for self-diagnosis and monitoring the symptomatic course of AC in women. The current study aimed to analyze the validity and reliability of the German ACSS in German-speaking female patients with AC in Switzerland. Methods Anonymized patient data were collected and analyzed from women with AC at the first visit (diagnosis) and follow-up visits as baseline and controls, respectively. Data from 97 patients with a median age of 41 years underwent analysis. Psychometric and diagnostic characteristics of the ACSS were measured and statistically analyzed. Results Average internal consistency of the ACSS resulted in a Cronbach’s alpha (95% CI) of 0.86 (0.83; 0.89) and did not differ significantly between the Swiss and German cohorts. Diagnostic values of the ACSS for the Swiss cohort were relatively lower than for the German cohort, possible due to discrepancies between definitions of UTI in national guidelines. Conclusions The analysis showed that the German version of the ACSS is also suitable for use in the German-speaking female population of Switzerland. Minor differences in definitions of AC between German and Swiss guidelines explain the observed discrepancies in diagnostic values of the ACSS between cohorts.

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“…The ACSS has been proven to be suitable for the clinical diagnosis of AUC in women and in monitoring treatment success during and after therapy [30][31][32][33][34]. Furthermore, it has already been used as a "patient-reported outcomes measure" (PROM) in several clinical studies [31,32,[35][36][37][38].…”

Section: Clinical Diagnosis and Assessment Of Treatment Efficacy In U...mentioning

confidence: 99%

Why d-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections—Preliminary Considerations and Conclusions from a Non-Interventional Study

et al. 2022

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Urinary tract infections (UTIs) are very frequent in women and can be caused by a range of pathogens. High recurrence rates and increasing antibiotic resistance of uropathogens make UTIs a severe public health problem. d-mannose is a monosaccharide that can inhibit bacterial adhesion to the urothelium after oral intake. Several clinical studies have shown the efficacy of d-mannose in the prevention of recurrent UTIs; these also provided limited evidence for the efficacy of d-mannose in acute therapy. A recent prospective, non-interventional study in female patients with acute cystitis reported good success rates for treatment with d-mannose. Here, we present data from a post hoc analysis of this study to compare the cure rate of d-mannose monotherapy with that of antibiotics. The results show that d-mannose is a promising alternative to antibiotics in the treatment of acute uncomplicated UTIs in women.

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Acute Cystitis Symptom Score questionnaire for measuring patient-reported outcomes in women with acute uncomplicated cystitis: Clinical validation as part of a phase III trial comparing antibiotic and nonantibiotic therapy

Cited by 10 publications

References 27 publications

Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis

Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis

Linguistic and clinical validation of the acute cystitis symptom score in German-speaking Swiss women with acute cystitis

Why d-Mannose May Be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections—Preliminary Considerations and Conclusions from a Non-Interventional Study

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