Linguistic and clinical validation of the Turkish version of Acute Cystitis Symptom Score for the diagnosis and patient-reported outcome in acute uncomplicated cystitis

Abstract

Purpose The Acute Cystitis Symptom Score (ACSS) was developed as a self-reporting questionnaire for diagnosing and monitoring acute uncomplicated cystitis (AC) in female patients. The study aims at the translation of the ACSS into Turkish from the original Uzbek including its linguistic, cognitive and clinical validation. Materials and Methods After forward and backward translation of the ACSS from Uzbek to Turkish and vice versa, the cognitive assessment of the Turkish ACSS was performed on 12 female subjects to achieve the final study version. Results The clinical validation was performed on a total of 120 female respondents including 64 Patients with AC and 56 controls without AC. For clinical diagnosis of AC, the predefined summary score of the typical symptoms of >6 showed high values (95% confidence interval) for sensitivity (0.88 [0.77–0.94]), specificity (0.98 [0.91–1.00]), and diagnostic accuracy (0.93 [0.86–0.97]). All patients were followed up between five to nine days after the baseline visit. Forty-four (68.75%) patients used antimicrobial treatment, whereas the rest (31.25%) preferred non-antimicrobial treatment. The severity scores of the typical symptoms and the quality of life were reduced significantly at follow-up. Using different (favored) thresholds for successful and non-successful treatment a clinical success rate between 54.7% and 64.1% (60.9%) was achieved. Conclusions After translation from the original Uzbek and cognitive assessment, the Turkish ACSS showed similar good results for clinical diagnosis and patient-reported outcome as in other languages validated so far and could therefore now be used for clinical studies as well as in everyday practice.

Linguistic and Clinical Validation of the Tajik Acute Cystitis Symptom Score for Diagnosis and Patient-Reported Outcome in Acute Uncomplicated Cystitis

“…After translating according to the accepted international guidelines [ 24 , 25 , 26 ] from the original source language, Russian [ 15 ] ( Supplementary Table S2 ), into Tajik as the target language, the final Tajik version of the ACSS was used for the clinical study ( Table 1 , Supplementary Table S3 ).…”

“…The linguistic and clinical validation of the Tajik ACSS was conducted according to internationally accepted guidelines, as for the previous languages [ 24 , 25 , 26 ]. In contrast to other languages, the Tajik ACSS showed the best diagnostic balance between sensitivity and specificity at a summary score of typical symptoms of 5 rather than 6 and above.…”

“…The translation of the Tajik version was carried out according to accepted international guidelines [ 24 , 25 , 26 ] with the following steps: the initial Russian version of the ACSS [ 15 ] was first translated into Tajik (the target language) by two professional translators with Tajik as their mother language. The translators were blinded to each other and worked independently.…”