Acute cold‐ and chronic heat‐exposure upregulate hepatic leptin and muscle uncoupling protein (UCP) gene expression in broiler chickens

Dridi, Sami; Temim, Soraya; Derouet, Michel; Tesseraud, Sophie; Taouis, Mohammed

doi:10.1002/jez.461

Cited by 34 publications

(24 citation statements)

References 61 publications

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“…This is consistent with earlier studies (Dridi et al, 2004) and suggests that UCP may affect animal performance by increasing energy dissipation by mitochondrial oxidation. Contrary to published findings, in which several studies showed that UCP mRNA expression may change as a function of environmental temperature (Toyomizu et al, 2002;Dridi et al, 2008), we did not observe any environmental effect on UCP mRNA expression.…”

Section: Discussioncontrasting

confidence: 87%

The effect of heat stress onGHR,IGF-I,ANT,UCPandCOXIIImRNA expression in the liver and muscle of high and low feed efficiency female quail

Gasparino

Vesco

Voltolini

et al. 2014

British Poultry Science

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1. A study was conducted to test the hypothesis that feed efficiency (FE) correlated with the expression of genes from the somatotropic axis and mitochondrial genes involved in energy production, and that the environment to which the birds are exposed influenced the expression of such genes. 2. Quails were divided into High-FE and low-FE groups and maintained in a comfortable or heat stress (HS) (38°C for 24 h) environment to evaluate changes in insulin-like growth factor I (IGF-I), growth hormone receptor (GHR), adenine nucleotide translocator (ANT), uncoupling protein (UCP) and cytochrome oxidase subunit III (COX III) messenger ribonucleic acid (mRNA) expression in liver and muscle tissues. 3. High-FE quails (0.28 g/g) presented a higher final body weight, greater weight gain and a better feed conversion ratio than low-FE birds (0.18 g/g). High-FE birds showed greater IGF-I mRNA expression in the liver and muscle and greater GHR mRNA expression in the muscle. 4. Environmental effects only affected GHR expression in the liver, with quails under comfortable conditions exhibiting greater GHR expression than quails subjected to HS. 5. There was a significant interaction between FE and environmental temperature on ANT mRNA expression in the liver. The greatest ANT mRNA expression was observed for high FE-birds that remained under comfortable conditions. 6. In the liver, UCP mRNA expression did not differ among the quails and was not affected by environment or efficiency. However, comparisons of the low- and high-FE birds revealed higher levels of UCP mRNA in the muscle of low-FE birds. 7. COX III mRNA expression in the liver was dependent on environmental temperature and FE. Higher COX III mRNA expression was observed in animals that remained under comfortable conditions, and high-FE birds exhibited higher expression levels compared to low-FE birds. 8. These results suggest a correlation between IGF-I, GHR, ANT, UCP and COX III gene expression and FE and that environmental temperature could affect the expression of some of these genes.

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Section: Discussioncontrasting

confidence: 87%

The effect of heat stress onGHR,IGF-I,ANT,UCPandCOXIIImRNA expression in the liver and muscle of high and low feed efficiency female quail

Gasparino

Vesco

Voltolini

et al. 2014

British Poultry Science

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“…This finding is partially in agreement with the reports in humans, in which cold exposure increases circulating irisin levels, possibly associated with shivering-related muscle contraction and augmentation of brown fat-like thermogenesis (Lee et al, 2014). In birds, owing to lack of the brown adipose tissue (BAT) for heat production, thus, skeletal muscle is an important source of thermogenesis for body to counter cold (Dridi et al, 2008;Raimbault et al, 2001;Toyomizu et al, 2002;Ueda et al, 2005). Of the multiple factors involved in cold-induced thermogenesis, avian uncoupling protein homolog (avUCP) and PPARγ co-activator-1ɑ (avPGC1-ɑ) in chicken muscle can be induced by cold (Raimbault et al, 2001;Ueda et al, 2005), and thus are suggested to play critical roles in cold-induced adaptive thermogenesis and muscle fiber type conversion (Ueda et al, 2005).…”

Section: Upregulation Of Cfndc5 Expression In Chicken Skeletal Musclesupporting

confidence: 90%

Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure

Fang

et al. 2015

Gene

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“…Several studies have shown that UCP mRNA expression changes as a function of air temperature (Dridi et al 2008). We observed that, in the liver, high and low FE birds had significantly lower UCP mRNA expression under heat stress.…”

Section: Discussionmentioning

confidence: 66%

Thermal stress induces changes in gene expression and blood parameters in high and low feed efficiency meat quail

et al. 2014

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In this study, we analysed markers of stress, plasma creatinine and T3 content, and insulin-like growth factor I (IGF-I), growth hormone receptor (GHR), uncoupling protein (UCP), adenine nucleotide translocase (ANT) and cytochrome c oxidase subunit III (COX III) mRNA expression in the liver and muscle of high (0.22 g/g) and low (0.14 g/g) feed efficiency (FE) meat quail at three different air temperatures, comfortable, heat and cold stress, for 24 h. High FE quail presented higher plasma T3 and lower creatinine levels. IGF-I mRNA expression was higher in the livers of high FE quail than in the livers of low FE quail under both comfortable and cold stress conditions. In the muscle, regardless of the environment, high FE birds showed higher IGF-I mRNA expression. High FE birds also showed higher GHR mRNA expression under comfortable conditions. Regarding the environment, higher expression was observed in birds at comfortable conditions, and lower expression in birds under heat stress. UCP mRNA expression in the liver was lower in high FE birds and higher under heat stress compared with the other conditions. Low and high FE birds showed greater ANT mRNA expression in the muscle under cold stress. Greater mRNA COX III expressions were observed in the liver and muscle of quails under comfortable conditions. Our results suggest that temperature affects the expression of genes related to growth and mitochondrial energy production, and quail with different FEs respond differently to environmental stimuli. In comfortable conditions, high FE animals show higher IGF-I mRNA expression and plasma T3 and lower creatinine content.

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Acute cold‐ and chronic heat‐exposure upregulate hepatic leptin and muscle uncoupling protein (UCP) gene expression in broiler chickens

Cited by 34 publications

References 61 publications

The effect of heat stress onGHR,IGF-I,ANT,UCPandCOXIIImRNA expression in the liver and muscle of high and low feed efficiency female quail

The effect of heat stress onGHR,IGF-I,ANT,UCPandCOXIIImRNA expression in the liver and muscle of high and low feed efficiency female quail

Characterization of fibronectin type III domain-containing protein 5 (FNDC5) gene in chickens: Cloning, tissue expression, and regulation of its expression in the muscle by fasting and cold exposure

Thermal stress induces changes in gene expression and blood parameters in high and low feed efficiency meat quail

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