Acute cholestatic liver injury caused by polyhexamethyleneguanidine hydrochloride admixed to ethyl alcohol

Ostapenko, Yu. N.; Brusin, Konstantin M.; Zobnin, Yu . V.; Shchupak, A. Y.; Vishnevetskiy, M K; Сенцов, В. Г.; Новикова, О В; Алексеенко, С. А.; Лебедько, О А; Puchkov, Y. B.

doi:10.3109/15563650.2011.592837

Cited by 41 publications

(31 citation statements)

References 14 publications

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“…The composition of these drugs included PHMGhl, diethylphthalate, and ethyl alcohol (92%). The most typical manifestation of acute poisoning was cholestatic hepatitis (Ivashkin, Buyeverov, 2007;Ostapenko et al, 2011). The development of toxic hepatitis was accompanied by significant disturbances in the metabolism of lipids (Makarov, Ryasenskii, 2009).…”

Section: Discussionmentioning

confidence: 99%

Influence of polymeric derivatives of guanidine on hydrobionts

Lysytsya¹,

Matvienko²,

Kozii³

et al. 2017

biologija

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It is known that polymeric derivatives of guanidine are actively used in many countries of the world as disinfectants and antiseptics. Polyhexamethylene guanidine (PHMG) and polyhexamethylene biguanidine (PHMB) are typical representatives of this class of compounds. They show a bacteriostatic effect in concentrations from 1 mg/l (or 10 -4 %) or above, and a bactericidal effect from 10 mg/l (10 -3 %) and above. It is considered that PHMG and PHMB are not very toxic to higher organisms. This is explained by the different mechanism of drugs action on prokaryotic and eukaryotic cells. However, their safety for the fauna of freshwater hydrocenoses has not been sufficiently studied.The toxic effect of the salts of PHMG on the representatives of various types and classes of hydrobionts was studied in the experiments.It has been established that the safe concentration of PHMG in water with a one-time action on selected test objects is 0.1 mg/l (10 -5 %). The histological analysis of a one-year-old carp that lived in an aquarium with a constant concentration of PHMG at 0.5 mg/l for 12 days showed that concentrations of an order of magnitude smaller -0.01 mg/l (10 -6 %) is absolutely safe to consider. Chronic intoxication of fish caused by sublethal doses of PHMG leads to the development of numerous disorders in the liver, kidneys, and spleen, and to the inflammation of the pancreatic islets.A comparative analysis of the toxicity of PHMG for microand macroorganisms does not allow us to state that the latter are less sensitive to this xenobiotic. So far, there are not enough convincing reasons to believe that the mechanisms of action of PHMG on pro and eukaryotic cells are fundamentally different. At the same time, the binding of PHMG molecules to suspended particles in water, organic and inorganic impurities, flocculation, and biodegradation by microorganisms leads to a rapid decrease of free active molecules of this biocide in aquatic ecosystems.

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Section: Discussionmentioning

confidence: 99%

Influence of polymeric derivatives of guanidine on hydrobionts

Lysytsya¹,

Matvienko²,

Kozii³

et al. 2017

biologija

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“…Around 2006, the curves both of male mortality and of fatal alcohol poisonings go smoothly downwards, which is compatible with some literature 5,54 , although in a diagram presented in 22 , the all-cause mortality in 2006 is slightly higher than in preceding and subsequent years. As discussed above, in 2006 there was "a mass wave of severe poisonings" 44,45 . This outbreak, i.e.…”

Section: Health Care Life Expectancy and Alcoholmentioning

confidence: 99%

“…Unrecorded figures were probably higher. Histologically, "cholestatic hepatitis with a severe inflammatory component" was reported 45 . Remarkably, the toxicological assessments of PHMG and a structurally related compound -polyhexamethylene biguanide (PHMB) have not shown any strong hepatotoxicity, whereas PHMG had broader margins of safety than PHMB.…”

Section: Health Care Life Expectancy and Alcoholmentioning

confidence: 99%

“…Apart from ethanol, this liquid contained 0.08-0.15% of diethyl phthalate and 0.1-0.14% of polyhexamethylene guanidine hydrochloride (PHMG). The registered number of poisonings with pronounced jaundice during the period August-November 2006 amounted to 12,611 cases, among them 1189 lethal ones 44,45 . Unrecorded figures were probably higher.…”

Section: Health Care Life Expectancy and Alcoholmentioning

confidence: 99%

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Rusya'da Alkol ve Alkolizm: Politikalar ve Etkileri

Jargin¹

2017

Arşiv Kaynak Tarama Dergisi

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The purpose of this review was to draw attention to certain aspects of alcohol consumption in Russia related to the public health: consequences of governmental anti-alcohol policies, use of alcoholrelated topics to distract public attention from shortages of public health and assistance, toxicity of some legally sold alcoholic beverages, offences against alcoholics and people with alcohol-related dementia.

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“…Another mass poisoning occurred in several places of the Russian Federation in 2006, particularly in Siberia. The number of poisonings with marked jaundice during the period August-November 2006 was reported to have amounted to 12,611, including 1189 lethal cases, reportedly caused by the disinfectant Extrasept-1, containing 0.08-0.15% of diethyl phthalate and 0.1-0.14% of polyhexamethylene guanidine (PHMG) hydrochloride sold in vodka bottles (Luzhnikov, 2014; Ostapenko et al ., 2011). Actual figures are unknown.…”

mentioning

confidence: 99%