Acute Chagas Disease in the Brazilian Amazon: Epidemiological and clinical features

Costa, E.; Santos, Soraya Oliveira dos; Sojo-Milano, Mayira; Amador, Ednei C.C.; Tatto, Erica; Souza, Dilma S.M.; Costa, Francisco de Assis; Póvoa, Rms

doi:10.1016/j.ijcard.2017.02.101

Cited by 23 publications

(17 citation statements)

References 8 publications

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“…When observing the age group in the young-adult phase (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39), it was presented the highest mean, differently from what the national data indicates. From 1980 to 2010, the elderly people aged 60 or older have the higher prevalence in the population that mainly covers the chronic form of CD.…”

Section: Discussionmentioning

confidence: 86%

“…Furthermore, domestic animals that are not confined may be links between the cycle of wild and domestic transmission. 3,18,22 Although the oral route has a higher rate of contamination of the local population of Amazonas, the vector transmission is prevalent in all the years of study, differently from the oral transmission found in 2007. This fact may be correlated with the intervention of surveillance in the ways of vector and transfusion transmissions.…”

Section: Discussionmentioning

confidence: 99%

“…This is considered low when compared to the Brazilian state of Pará, with a mean of 119, 14 which reinforces the hypothesis that the data form this study may be underreported, considering that of Chagas Disease in the Amazon Region -AMCHA), created in 2004, for mapping and detecting the disease transmission routes, even though it is still considered ineffective. 3,19,22 There is also the occurrence of triatomines in both, intra and peridomiciliary environments, which may as well contribute to the increase of up to 16% in the transmission of Chagas disease. 23 The presence of the insect in these environments may be due to deforestation, its capacity to adapt to new vertebrate hosts, the presence of natural biotopes in the vicinity of residences and the attraction to light of some species of triatomines.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological overview of chagas disease in the state of Amazonas, from 2004 to 2014

Menezes

Oliveira

Ribeiro

et al. 2019

Rev Epidemiol Control Infect

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Justificativa e Objetivos: A doença de Chagas (DC), causada pelo Trypanosma cruzi, protozoário flagelado, descoberto a mais de 100 anos, sendo ela difundida nas américas, principalmente na américa do Sul, acometendo milhões de pessoas pelo mundo. É cada vez mais crescente o número de indivíduos acometidos com a DC na região da Amazônia Ocidental e estão relacionados a diversos fatores, porém o consumo de bebida contaminada é a principal parcela de contribuição para a elevação nos registros da doença na região. Este estudo tem como objetivo descrever e analisar o panorama epidemiológico da doença de Chagas no estado do Amazonas de 2004 a 2014. Métodos: Trata-se de um estudo ecológico, onde foram utilizados somente dados secundários obtidos do Sinan referentes aos casos notificados de infecção por T. cruzi em todo o estado do Amazonas. Resultados: Constatou-se que no período de 2004 a 2014 que no estado do Amazonas ocorreram um total de 100 casos de DC, tendo maior ocorrência nos anos de 2007 e 2010, durante os meses de abril e dezembro, com maior frequência da faixa etária de 20-39 e no gênero feminino. Conclusão: Constatou-se a necessidade de implementar um serviço de controle epidemiológico eficaz para monitoramento da via de transmissão DC e de seus vetores, pois trata-se de um problema de saúde pública que pode estar ligada a determinantes sociais e culturais, sendo indicado a promoção de atividades educativas para a conscientização da comunidade a respeito desta enfermidade. Descritores: Epidemiologia. Tripanossomíase Americana. Amazônia

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological overview of chagas disease in the state of Amazonas, from 2004 to 2014

Menezes

Oliveira

Ribeiro

et al. 2019

Rev Epidemiol Control Infect

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“…In Brazil, prevalent chronic cases of CD result from infections acquired in the past, affecting approximately three million individuals [2, 3]. However, in recent years, the occurrence of acute Chagas disease (ACD) has been observed in the Amazon, with the manifestation of isolated cases in other states [4]. Trypanosoma cruzi is the etiologic agent of CD, a hemoflagellate protozoan from the Kinetoplastida order [5].…”

Section: Introductionmentioning

confidence: 99%

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Alexandre

Lima

Galuppo

et al. 2017

J Venom Anim Toxins Incl Trop Dis

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BackgroundMajor drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs for treating chronic Chagas disease requires immediate action. In this work, we evaluated the mushroom Pleurotus salmoneostramineus in the search for potential antiparasitic compounds.MethodsFruit bodies of the basidiomycete Pleurotus salmoneostramineus were triturated and submitted to organic solvent extraction. After liquid-liquid partition of the crude extract, three fractions were obtained and the bioguided fractionation study was conducted to isolate the active metabolites. The elucidation of the chemical structure was performed using GC-MS and NMR techniques. The biological assays for antiparasitic activity were carried out using trypomastigotes of Trypanosoma cruzi and murine macrophages for mammalian cytotoxicity. The mechanism of action of the isolated compound used different fluorescent probes to evaluate the plasma membrane permeability, the potential of the mitochondrial membrane and the intracellular levels of reactive oxygen species (ROS).ResultsThe most abundant fraction showing the antiparasitic activity was isolated and chemically elucidated, confirming the presence of ergosterol. It showed anti-Trypanosoma cruzi activity against trypomastigotes, with an IC50 value of 51.3 μg/mL. The compound demonstrated no cytotoxicity against mammalian cells to the maximal tested concentration of 200 μg/mL. The mechanism of action of ergosterol in Trypanosoma cruzi trypomastigotes resulted in permeabilization of the plasma membrane, as well as depolarization of mitochondrial membrane potential, leading to parasite death. Nevertheless, no increase in ROS levels could be observed, suggesting damages to plasma membrane rather than an induction of oxidative stress in the parasite.ConclusionsThe selection of naturally antiparasitic secondary metabolites in basidiomycetes, such as ergosterol, may provide potential scaffolds for drug design studies against neglected diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/s40409-017-0120-0) contains supplementary material, which is available to authorized users.

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“…In the Amazon region, the states with the highest number of CD case registers are Pará and Amazonas, with the main reasons for T. cruzi transmission being the construction of houses in rural locations near palm trees infested with triatomines and infected marsupials, associated with deforestation, which transforms the landscape and the biotope of the triatomines, allowing their invasion into the households 23,24 . The most frequent form of transmission is oral, mainly by the consumption of fruit juices and pulps, such as açaí and others from palm trees 9,10,[25][26][27][28] .…”

mentioning

confidence: 99%

Retrospective study of the epidemiological overview of the transmission of Chagas disease in the State of Acre, South-Western Amazonia, from 2009 to 2016

Oliveira¹,

Ribeiro²,

Castro³

et al. 2018

J. Hum. Growth Dev.

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Introduction: Chagas disease (CD), also known as American Trypanosomiasis, is an infectious parasitic disease caused by the etiologic agent Trypanosoma cruzi. It is considered endemic in the low-income population and is classified by the WHO as a neglected tropical disease. In the state of Acre, there is almost no scientific data regarding the epidemiology of CD, even though the first autochthonous case was registered in the 1980s. Objective: To analyze the epidemiological panorama of the transmission of Chagas disease in the State of Acre, Brazil, from 2009 to 2016. Methods: A survey of the occurrence of Chagas disease in the State of Acre was performed using public domain secondary data from the Brazil’s Notifiable Diseases Information System of SUS (publicly funded health care system), and from the SUS Database of the Health Surveillance Foundation of the State of Acre. Data were collected from the following variables: gender, age group, form of contagion, distribution by region and municipality, perimeter and seasonality. Result: Forty-two cases of CD were confirmed, with an increase of more than 300% from 2015 to 2016 and a frequency coefficient of 3.06 cases per 100,000 people, and in the Tarauacá/Envira region, the probability of a person contracting CD was 600% higher than the state mean. Conclusion: We found that in the state of Acre, in the period from 2009 to 2016, most cases of CD occurred in 2016, in the Tarauacá/Envira region, mainly in the municipality of Feijó, in the rural zone, from July to October, in the age group of 0 to 30 years, being the oral form the main route of transmission and presenting no statistical difference between men and women.

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Acute Chagas Disease in the Brazilian Amazon: Epidemiological and clinical features

Cited by 23 publications

References 8 publications

Epidemiological overview of chagas disease in the state of Amazonas, from 2004 to 2014

Epidemiological overview of chagas disease in the state of Amazonas, from 2004 to 2014

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria

Retrospective study of the epidemiological overview of the transmission of Chagas disease in the State of Acre, South-Western Amazonia, from 2009 to 2016

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