2017
DOI: 10.1186/s40409-017-0120-0
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Abstract: BackgroundMajor drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs for treating chronic Chagas disease requires immediate action. In this work, we evaluated the mushroom Pleurotus salmoneostramineus in the search for potential antiparasitic compounds.MethodsFruit bodies of the basidiomycete P… Show more

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Cited by 25 publications
(10 citation statements)
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“… 14 Compound 6 was found to be identical in all of its spectroscopic characteristics with that of ergosterol. 15 3β-Hydroxyergosta-7,22-diene was detected in the n -hexane fraction with the use of an authentic standard.…”
Section: Resultsmentioning
confidence: 99%
“… 14 Compound 6 was found to be identical in all of its spectroscopic characteristics with that of ergosterol. 15 3β-Hydroxyergosta-7,22-diene was detected in the n -hexane fraction with the use of an authentic standard.…”
Section: Resultsmentioning
confidence: 99%
“…Most of the current antifungal agents interfere with ergosterol-function in some way, either through inhibition of various steps in ergosterol biosynthesis (allylamines, azoles, morpholines) or by complexing directly with membrane ergosterol (polyenes). Biologically, ergosterol was reported to have several effective activities, for example it has an inhibitory effect on the activity of mucosal-type mast cells [40], anti- Trypanosoma cruzi activity against trypomastigotes (IC 50 51.3 μg/mL) [41], and antifungal activity as well. More recently, ergosterol derivatives were reported as Anti-tumor and Anti-angiogenic agents [42].…”
Section: Resultsmentioning
confidence: 99%
“…Negative IV values correspond to depolarization of the mitochondrial membrane. The FCCP (Carbonyl cyanide- p -Trifluoromethoxyphenylhydrazone) 20 μM was used as positive control [ 25 ].…”
Section: Methodsmentioning
confidence: 99%