Acute basophilic leukaemia in a calf

Takahashi, Yuya; Yoneyama, Shuji; Yamamoto, Shinji; Shibahara, Tomoyuki; Kadota, Koichi

doi:10.1136/vr.158.20.702

Cited by 10 publications

(18 citation statements)

References 1 publication

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“…In practice, however, various histologic types must be included in this category, when we consider the paucity of reports about other types of lymphoid neoplasms in calves. Moreover, it is probable that acute non-lymphocytic leukemias 21,23 are mistakenly classified into this category. Thus, the term "calf form of lymphoma" is used as a "catch-all" for calfhood neoplasms of the lymphoid and hemopoietic tissues for which immunohistochemistry and histochemistry are not performed.…”

Section: Fig 7 Case 2 Thymusmentioning

confidence: 99%

Immunohistochemical Characterization of Five Types of Lymphoid Neoplasms in Calves

Kagawa

Tomita

Nakatani

et al. 2009

JARQ

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Five types of lymphoid neoplasms in calves are described. Four cases with clinicopathologic features of the "calf form of lymphoma" were diagnosed as precursor B or T lymphoblastic leukemia. These neoplasms were positive for terminal deoxynucleotidyl transferase (TdT), a marker for immature lymphocytes. The fifth case (thymic B cell lymphoma) was also TdT positive, but was characterized by massive neoplastic involvement of the thymus. The sixth case involved bovine leukemia virus (BLV). As in the majority of previously reported BLV-associated cases, the neoplastic cells expressed CD5, and atypical giant cells were detected. Instead of enzootic bovine leukosis, in which at least two immunophenotypically distinct entities are included, a diagnosis of BLV-associated pleomorphic B-1 B cell lymphoma was made. The last case, involving an epitheliotropic γδ T cell lymphoma, was characterized by epitheliotropism in the gastrointestinal tract and WC1 expression. Since several histologic types of lymphoid neoplasm occur in calves, the term "calf form of lymphoma" should be abandoned for accurate diagnosis.

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Section: Fig 7 Case 2 Thymusmentioning

confidence: 99%

Immunohistochemical Characterization of Five Types of Lymphoid Neoplasms in Calves

Kagawa

Tomita

Nakatani

et al. 2009

JARQ

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“…In contrast, there were no distinct particles in the current case. Although the bone marrow was not examined histologically, the absence of tumor masses, the preponderance of atypical cells on the blood smears, and the presence of many blast cells within pulmonary alveolar capillaries indicated that this case was an acute leukemia [6,8,12]. On the basis of these findings, the final diagnosis of acute myeloid leukemia with mastocytic and megakaryocytic differentiation was made.…”

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confidence: 99%

“…In addition to the current case, acute basophilic leukemia [12], acute myelomonocytic leukemia [16], and acute erythremic myelosis (pure erythroid leukemia) [15] have been reported in calves. Considering the large population of the normal counterpart cells, reports of non-lymphocytic leukemias seem to be too few.…”

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confidence: 99%

“…Cells of the megakaryocytic lineage were characterized by positivity for factor VIII-related antigen [2], whereas some others contained metachromatic or tryptase-positive granules. Since CAE activity has been observed in a bovine cutaneous mastocytoma but not in a bovine acute basophilic leukemia [12], the neoplastic cells with CAE-positive metachromatic granules were considered to belong to the mast cell lineage. This view was supported by ultrastructural findings: Takahashi et al [12] observed particles in granules of electron density in basophilic leukemia.…”

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confidence: 99%

“…Since CAE activity has been observed in a bovine cutaneous mastocytoma but not in a bovine acute basophilic leukemia [12], the neoplastic cells with CAE-positive metachromatic granules were considered to belong to the mast cell lineage. This view was supported by ultrastructural findings: Takahashi et al [12] observed particles in granules of electron density in basophilic leukemia. In contrast, there were no distinct particles in the current case.…”

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confidence: 99%

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Acute Myeloid Leukemia with Mastocytic and Megakaryocytic Differentiation in a Calf

Ikehata

Wada

Ishikawa

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. A diagnosis of acute myeloid leukemia was made in a 10-month-old Holstein female calf. The leukemia was macroscopically characterized by great enlargement of the spleen and moderate enlargement of some lymph nodes. Histochemical and immunohistochemical examination disclosed the presence of neoplastic cells either containing metachromatic and tryptase-positive granules or expressing factor VIII-related antigen. The granules, which were positive for naphthol AS-D chloroacetate esterase and did not have particulate contents, were distinct from those of basophilic leukemia cells. This leukemia was thought to be derived from a common myeloid progenitor capable of giving rise to megakaryocyte-erythrocyte progenitors and granulocyte-monocyte progenitors with the ability to differentiate into mast cells.KEY WORDS: cattle, factor VIII-related antigen, myeloid leukemia, tryptase.

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Diseases of the Hemolymphatic and Immune Systems

2017

Veterinary Medicine

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Acute basophilic leukaemia in a calf

Cited by 10 publications

References 1 publication

Immunohistochemical Characterization of Five Types of Lymphoid Neoplasms in Calves

Immunohistochemical Characterization of Five Types of Lymphoid Neoplasms in Calves

Acute Myeloid Leukemia with Mastocytic and Megakaryocytic Differentiation in a Calf

Diseases of the Hemolymphatic and Immune Systems

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