Immunohistochemical Characterization of Five Types of Lymphoid Neoplasms in Calves

Kagawa, Yuuichi; Tomita, Keisuke; Nakatani, Hidetsugu; Sato, Koya; Wada, Yasuhiko; Ishikawa, Yoshiharu; Kadota, Koichi

doi:10.6090/jarq.43.239

Cited by 16 publications

(35 citation statements)

References 19 publications

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“…The neoplastic cells in the former were characterized by moderate clumping of chromatin and medium-sized nucleoli, and similar cytologic features have been seen in precursor T lymphoblastic leukemia 7 . On the other hand, the lymphoma cells in the latter, which had nuclei with inconspicuous nucleoli and finely dispersed chromain, resembled those in precursor B-1 B cell lymphoma 16 or in immature γδ T cell lymphoma (unpublished data).…”

Section: Discussionmentioning

confidence: 68%

“…Bar = 10 µm. teristic of late-stage lymphoblastic leukemia 7 . Formation of large tumor masses with stromal fibrosis, which was observed in case 2, characterizes thymic B cell and T cell lymphomas 7,17 .…”

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

“…teristic of late-stage lymphoblastic leukemia 7 . Formation of large tumor masses with stromal fibrosis, which was observed in case 2, characterizes thymic B cell and T cell lymphomas 7,17 . Cytologic pleomorphism and atypia were confirmed in cases 3-5, and we judged that the cases were etiologically associated with BLV.…”

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

“…Although the disease must be differentiated from other lymphohematopoietic neoplasms for proper reporting, diagnosis is based on the age of affected animals, sites of tumor formation, and BLV infection 14 . T cell malignancies such as precursor T lymphoblastic leukemia 7 and γδ T cell lymphoma 1 have been reported in BLV-infected cattle, and were thought to have no relation to the virus 5 . Sporadic lymphoid neoplasms are divisible into calf, thymic, and cutaneous forms, but more than one disease entity is included in each form 2,6,7,12,16,17,19 .…”

Section: Introductionmentioning

confidence: 99%

“…T cell malignancies such as precursor T lymphoblastic leukemia 7 and γδ T cell lymphoma 1 have been reported in BLV-infected cattle, and were thought to have no relation to the virus 5 . Sporadic lymphoid neoplasms are divisible into calf, thymic, and cutaneous forms, but more than one disease entity is included in each form 2,6,7,12,16,17,19 . Taking into account the large population of normal hematopoietic cells in the bone marrow, a fair number of myeloid leukemias must occur in cattle.…”

Section: Introductionmentioning

confidence: 99%

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Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

JARQ

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Ten cases of bovine lymphohematopoietic neoplasms were investigated histologically, histochemically, and immunohistochemically, and were classified into eight histologic types on the basis of the origin and morphology of tumor cells. Case 1, a precursor B lymphoblastic leukemia, was positive for CD79a and terminal deoxynucleotidyl transferase. Case 2, a thymic B cell lymphoma, was also positive for these markers, but there were cytologic differences between the two cases. Cases 3-5 were diagnosed as pleomorphic B cell lymphomas, which were characterized by cytologic pleomorphism and expression of CD79a and CD5, and were etiologically associated with bovine leukosis virus (BLV). A case of diffuse large B cell lymphoma of the cerebrum (case 6) also showed a positive result for CD79a and CD5. However, the lymphoma was composed of a homogeneous population of large neoplastic cells, and was considered to be unrelated to BLV. The other B cell cases were categorized into immunoblastic (case 7) and lymphoplasmacytic (case 8) lymphomas, in which immunoglobulin-producing lymphoma cells were observed. In a cutaneous γδ T cell lymphoma (case 9), the neoplastic cells cytologically resembled those in case 6, but expressed CD3 and WC1. In case 10, an acute basophilic leukemia, some leukemia cells had intracytoplasmic granules that were metachromatic and tryptase positive but negative for naphthol AS-D chloroacetate esterase. Bovine lymphohematopoietic malignancies are classifiable into discrete histologic types according to immunophenotype. The classification is more scientific than the traditional one, the latter being based on the age of affected animals and/or the site of tumor formation.

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Section: Discussionmentioning

confidence: 68%

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

JARQ

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Disseminated thymic B-cell lymphoma in a Holstein heifer

et al. 2019

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A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.

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Cytologic Variants of .GAMMA..DELTA. T Cell Lymphoma in Cattle

Ito

Kubo

Takayama

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Two cytologic variants of  T cell lymphoma are described. Case 1 represented a giant cell variant found in a 5-year-old Holstein cow, which had large tumor masses in the pelvic cavity. This variant consisted of very large lymphoid cells with round to oval nuclei, medium-sized nucleoli and abundant cytoplasm. Case 2 was an aborted 7-month-old female Holstein fetus, which represented an immature cell variant. Most of the neoplastic lesions were located in the skin and pleural and peritoneal submesothelial tissues. The neoplastic tissues were composed of homogeneous growth of lymphoma cells characterized by inconspicuous nucleoli and finely dispersed chromatin. Both cases demonstrated CD3, CD8 and WC1 immunoreactivity. The current study revealed that there are 4 cytologic variants (common, giant cell, hypergranular and immature cell) in bovine  T cell lymphomas.

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Immunohistochemical Characterization of Five Types of Lymphoid Neoplasms in Calves

Cited by 16 publications

References 19 publications

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Disseminated thymic B-cell lymphoma in a Holstein heifer

Cytologic Variants of .GAMMA..DELTA. T Cell Lymphoma in Cattle

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