Cytologic Variants of .GAMMA..DELTA. T Cell Lymphoma in Cattle

Ito, Masanori; Kubo, Midori; Takayama, Hiroaki; Ishikawa, Yoshiharu; Kadota, Koichi

doi:10.1292/jvms.10-0365

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…Similar to the reports for pleomorphic B cell lymphoma 1,9,13. , in this study the main cytological findings from cases 1-16 were pleomorphism and atypia, which are not so prominent in other histological types of lymphoid neoplasms 1,2,[6][7][8][9][10]13,14,17,18 . Such features were considered characteristic of the majority of lymphoma cases truly associated with BLV.…”

Section: Discussionmentioning

confidence: 73%

“…These classifications are based on the cell size and/or nuclear cleavage and fail to distinguish between BLV-positive and negative cases. In contrast, some cases of BLV-positive lymphoma, which were diagnosed as pleomorphic B cell lymphoma based on pleomorphism and atypia 1,9.13 , were cytologically distinct from other lymphoid malignancies 1,2,[6][7][8][9][10]13,14,17,18 . In this paper, we describe the histology and immunohistochemistry of B cell lymphomas in 17 cows having tested positive for BLV by nested polymerase chain reaction (PCR).…”

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confidence: 99%

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Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Iwama

Inomata

Ishikawa

et al. 2013

JARQ

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Lymphoid neoplasms in 17 cattle having tested positive for bovine leukosis virus (BLV) were investigated by histology and immunohistochemistry. In 16 cases, the neoplastic cells were characterized by a marked variation in cell size, atypia in large cells, nuclear irregularity in smaller cells, and nucleolar prominence in cells with scant cytoplasm. These cytological features were used to specifically define pleomorphic lymphomas. In addition to lymphoid cells, immunoblastoid and plasmacytoid cells containing cytoplasmic immunoglobulin G were observed in the remaining case. Since a similar case was recorded as lymphoplasmacytoid lymphoma in a BLV-negative cow, this polymorphic case may not be related to the virus. Most lymphoma cases associated with BLV are classified as pleomorphic, and neoplasms termed enzootic leukosis should be diagnosed based on tumor cell morphology.

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Section: Discussionmentioning

confidence: 73%

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confidence: 99%

Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Iwama

Inomata

Ishikawa

et al. 2013

JARQ

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“…The WHO classification of human lymphoid neoplasms is not directly applicable to bovine neoplasms and requires certain modifications [6,9,17]. The current study disclosed the presence of four distinct entities-thymic B cell lymphoma, intestinal large B cell lymphoma, thymic γδ T cell lymphoma and γδ T cell lymphoma with tropism for various epithelia-that are not listed in the human classification.…”

Section: Discussionmentioning

confidence: 79%

“…Since similar features were observed, cases 13-17 were diagnosed as γδ T cell lymphoma. Considering the high proportion of γδ T lymphocytes in swine peripheral blood [21], this type of lymphoma, as in cattle [6], is probably not rare. Despite such similarities between the bovine and swine cases, the neoplastic cells were far more pleomorphic in the swine cases.…”

Section: Discussionmentioning

confidence: 99%

Lymphoid Neoplasms in Swine

Ogihara

Ohba²,

Takai

et al. 2012

J. Vet. Med. Sci.

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ABSTRACT. Seventeen cases of lymphoid neoplasms in swine were investigated and divided into eight histological types. Cases 1-3 were precursor B lymphoblastic leukemias, which occurred in three piglets from the same dam. Cases 4 and 5 were diagnosed, respectively, as a precursor B lymphoblastic lymphoma and a thymic B cell lymphoma, because there were cytological differences between the lymphomas. These five cases of immature B cell malignancies expressed CD79a and terminal deoxynucleotidyl transferase (TdT). Mature B cell lymphomas were divisible into follicular (case 6), diffuse centroblastic (case 7) and intestinal large B cell (cases 8-11) lymphomas. Unlike in case 7, the neoplastic cells in cases 8-11 showed cytological features intermediate between centroblasts and immunoblasts. The mature lymphomas were characterized by positive immunolabeling for CD79a and cytoplasmic immunoglobulins. A case of thymic  T cell lymphoma (case 12) were positive for CD3, CD5, WC1 and TdT. Instead of TdT, perforin was expressed in  T cell lymphomas (cases 13-17), whose histological characteristics were epitheliotropism, homing into T cell zones of lymphatic tissues, and cytological atypia and pleomorphism. In the present study, lymphoid neoplasms could be classified into discrete histological types, some of which were considered to be specific for swine.

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“…In cattle, immature lymphoid neoplasms are divisible into several types based on the immunophenotype and tissue distribution of neoplastic lesions [ 5 , 6 , 7 , 19 , 20 ], with nearly all cases expressing terminal deoxynucleotidyl transferase (TdT), a marker for immature lymphocytes. Thymic lymphoma is characterized by formation of large tumor masses with stromal fibrosis in the mediastinum [ 16 ].…”

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Immature T cell neoplasms in three young cattle

R¹,

Sato²,

Wada

et al. 2015

The Journal of Veterinary Medical Science

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Immature T cell neoplasms in three young Holstein cattle with neoplastic involvement of the thymus are described. Case 1, with a precursor T lymphoblastic leukemia (calf form of leukosis), was an 86-day-old female calf. The leukemia was characterized by replacement of the bone marrow and spleen by leukemia cells, but preservation of epithelial frameworks throughout the thymus. The other two neoplasms were thymic γδ T cell lymphomas, which were observed in a 246-day-old steer (case 2) and a 16-month-old heifer (case 3). Histological examination revealed obliteration of the normal thymic architecture and stromal fibrosis, with the spleen and liver far less severely affected than in case 1. There were cytological differences bewteen the tumors in case 1 and cases 2 and 3. Additionally, WC1 and CD8 were expressed only in the latter. Thus, the leukemia and these lymphomas should be regarded as independent disease entities on the basis of histological and immunohistochemical characteristics.

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Cytologic Variants of .GAMMA..DELTA. T Cell Lymphoma in Cattle

Cited by 7 publications

References 15 publications

Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Cytology of B Cell Lymphomas in Cattle Infected with Bovine Leukosis Virus

Lymphoid Neoplasms in Swine

Immature T cell neoplasms in three young cattle

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