Acute appendicitis

Stringer, Mark D.

doi:10.1111/jpc.13737

Cited by 91 publications

(91 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In preschool children, this obstruction is typically due to lymphoid hyperplasia and less likely due to fecalith, as the appendix contains an excessive amount of lymphoid tissue in the submucosa [ 14 ]. Furthermore, the presence of a fecalith causes luminal obstruction, distention, and inflammation of the appendix wall, resulting in suppurative transmural inflammation, ischemia, infarction, and perforation of the appendix [ 20 ]. Numerous studies demonstrated that cytokines (e.g., interleukin-6 (IL-6)) [ 21 ] or acute phase proteins (e.g., CRP) could be used to predict the AA [ 1 ], control the severity of disease, and detect any complications [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Chen

Zhu

et al. 2020

Journal of Immunology Research

View full text Add to dashboard Cite

Background. Several efforts have been made to find out a valuable marker to assist the diagnosis and differentiation of gangrenous/perforated appendicitis. We aimed to determine the diagnostic capacity of soluble B7H3 (sB7H3) in acute appendicitis (AA) and its accuracy as a predictor of the severity of appendicitis. Methods. 182 children were allocated into four groups as follows: control group (CG, 90), simple appendicitis (SA, 12), purulent appendicitis (PA, 49), and gangrenous appendicitis (GA, 31). Prior to appendectomy, blood was collected and sent for analysis of routine examination and cytokines (sB7H3 and TNF-α). We compared values of all measured parameters according to histological findings. Furthermore, we assigned AA patients into the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic effects of significant markers were assessed by ROC curves. Results. Only the levels of CRP, FIB, and sB7H3 had a remarkable rising trend in AA-based groups, while differences in the levels of CRP and FIB between simple appendicitis and purulent appendicitis were not statistically significant. In addition, sB7H3 was found as the only marker in children with AA, which was markedly associated with the degree of histological findings of the appendix. Furthermore, sB7H3 had a high diagnostic value in predicting AA and complex appendicitis (PA+GA) in children. However, the diagnostic performance of sB7H3 for distinguishing PA from GA was not remarkable. Additionally, only the levels of CRP and sB7H3 were statistically different between the nonperforated appendicitis group and the perforated appendicitis group. The diagnostic performance of CRP and sB7H3 could not merely predict perforation of AA in children; however, the diagnostic performance was improved after combination. Conclusions. sB7H3 could be used as a valuable marker to predict the presence of AA and complex AA in children. However, the diagnostic value of sB7H3 to predict gangrenous/perforated appendicitis was not found to be remarkable. The combination of sB7H3 and CRP might improve the prediction of perforated appendicitis.

show abstract

Section: Discussionmentioning

confidence: 99%

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Chen

Zhu

et al. 2020

Journal of Immunology Research

View full text Add to dashboard Cite

show abstract

“…Although not mandatory, imaging examinations are very helpful in confirming or excluding the diagnosis in an emergency setting. Regardless of the imaging modality-ultrasound, computed tomography (CT) or magnetic resonance imaging-the findings are quite similar and reflect the chronology of the known physiopathology, including luminal obstruction, appendicular distention, and inflammation, as well as the progression to suppurated transmural inflammation, ischemia, infarction, and perforation ( 3 ) .…”

Section: Introductionmentioning

confidence: 99%

Morphologic criteria of vermiform appendix on computed tomography and a possible risk of developing acute appendicitis

et al. 2019

View full text Add to dashboard Cite

Objective: To evaluate the correlation of morphological criteria of the cecal appendix using computed tomography (CT) and the possible risk of developing acute appendicitis. Materials and Methods: Cases were defined as patients with surgically confirmed acute appendicitis who had undergone CT at least twice: at diagnosis and at least one month prior. Controls were defined as emergency patients with abdominal pain who had undergone abdominal CT that excluded acute appendicitis and had also undergone CT at least one month before. Results: 100 cases and 100 controls were selected for inclusion in the final analysis. Comparisons between the cases and controls revealed the following: mean transverse diameter of 0.6 cm (range, 0.4-1.0 cm) versus 0.6 cm (range, 0.6-0.8 cm; p = 0.37); mean length of 6.6 cm (range, 3.5-9.7 cm) versus 6.6 cm (range, 4.5-8.3 cm; p = 0.87); mean angle of 100° (range, 23-178°) versus 86° (range, 43-160°; p = 0.01); vertical descending orientation in 56% versus 45% (p = 0.2); absence of gas in 69% versus 77% (p = 0.34); and presence of an appendicolith in 17% versus 8% (p = 0.08). Conclusion: Hypothetical risk factors for obstruction of the vermiform appendix detected on CT were not associated with acute appendicitis. That suggests that factors other than those related to mechanical obstruction are implicated in the pathogenesis of acute appendicitis.

show abstract

“…Acute appendicitis makes up 30% of the causes of emergency consultations for abdominal pain in pediatric patients (1). Early identification, timely surgical management and prompt hospital discharge by reducing associated complications are the main purposes of comprehensive management of patients with surgical abdominal pathology (2).…”

Section: Introductionmentioning

confidence: 99%

Experiencia en la atención de pacientes menores de 16 años con apendicitis aguda en el Hospital Universitario San Ignacio entre los años 2014 y 2019

Ramírez¹,

Cano²,

Sanchez³

et al. 2020

Univ. Med.

View full text Add to dashboard Cite

Objective: To describe the characteristics of the care of patients under 16 years old with acute appendicitis taken to appendectomy between January 2014 and May 2019. Methodology: Retrospective descriptive observational study of the records of patients with acute appendicitis over 5 years. Results: 257 records met the inclusion criteria. The average age of the patients was 9.5 years. The average diagnosis time from admission was 7 hours and they were taken to surgery in the first 6 hours after diagnosis. The majority were uncomplicated appendicitis with a low percentage of postoperative complications. Six percent of patients underwent intraoperative peritoneal fluid culture without this involving significant changes in medical behavior. Conclusions: The success in the management of acute appendicitis in pediatric patients of hospital reflects high quality care. The use of ampicillin sulbactam as an empirical management shows favorable results with a low complication rate. Peritoneal fluid culture did not generate changes in medical or surgical behavior. Given the above, it is feasible to make reasonable use of resources, providing high quality care with optimal results and a lower cost to the health system.

show abstract

Acute appendicitis

Cited by 91 publications

References 10 publications

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

sB7H3 in Children with Acute Appendicitis: Its Diagnostic Value and Association with Histological Findings

Morphologic criteria of vermiform appendix on computed tomography and a possible risk of developing acute appendicitis

Experiencia en la atención de pacientes menores de 16 años con apendicitis aguda en el Hospital Universitario San Ignacio entre los años 2014 y 2019

Contact Info

Product

Resources

About