Uric acid, a metabolic product of purines, may exert a role in tissue healing. In
this review we will explore its role as an alarm initiating the inflammatory process
that is necessary for tissue repair, as a scavenger of oxygen free radicals, as a
mobilizer of progenitor endothelial cells and as supporter of adaptive immune
system.
ObjectiveTo describe the prevalence of carpal tunnel syndrome in a sample of 200 healthy
hospital workers, establishing the respective epidemiological associations.Materials and MethodsTwo hundred individuals were submitted to wrist ultrasonography to measure the
median nerve area. They were questioned and examined for epidemiological data,
body mass index, carpal tunnel syndrome signs and symptoms, and submitted to the
Boston carpal tunnel questionnaire (BCTQ) to evaluate the carpal tunnel syndrome
severity. A median nerve area ≥ 9 mm2 was considered to be
diagnostic of carpal tunnel syndrome.ResultsCarpal tunnel syndrome was diagnosed by ultrasonography in 34% of the sample. It
was observed the association of carpal tunnel syndrome with age
(p < 0.0001), paresthesia (p < 0.0001),
Tinel’s test (p < 0.0001), Phalen’s test (p
< 0.0001), BCTQ score (p < 0.0001), and years of formal
education (p < 0.0001). Years of formal education was the only
variable identified as an independent risk factor for carpal tunnel syndrome (95%
CI = 1.03 to 1.24).ConclusionThe prevalence of carpal tunnel syndrome in a population of hospital workers was
of 34%. The number of years of formal education was the only independent risk
factor for carpal tunnel syndrome.
Introduction: Tendinopathies and tendon tears account for over 30% of all musculoskeletal consultations. Obesity, which is becoming one of the world´s most prevalent public health issues, may be associated with this condition.Objective: To review the literature about tendinopathies and obesity association.Methods: This is a descriptive exploratory study using the portal Medline. Literature in English language from 2006 to 2014 were reviewed.Results: The pathogenesis of tendinopathies includes inflammatory, regenerative and degenerative processes that happen simultaneously from early to late phases of the disease. Mechanical stress upon tendons seems to be one of the most important factors to initiate the inflammatory response, but it´s not the only one that can deflagrate it: there are other extrinsic, genetic and metabolic factors that may be involved. Therefore, tendinopathies in obese patients can be due to tendon overload because of the excess of weight, but also because of increased production of pro-inflammatory mediators related to fat tissue such as adipokines. This pro-inflammatory state that obese people can suffer is known as adiposopathy, or sick fat syndrome. Weight loss is associated with decrease in adipokines and improvement of musculoskeletal symptoms.Conclusion: The relation of obesity and tendinopathies is supported by evidences of recent studies, exemplified in this review of literature.
Hip arthroplasty is a widely used and successful orthopedic procedure for the treatment of degenerative, inflammatory, or traumatic joint disease. The procedure promotes significant pain relief, as well as recovery of limb function, reduction of disability, and better quality of life. However, there are related complications, which have characteristic imaging aspects. In the present study, we review the literature and exemplify such complications using images obtained at our facility, illustrating the main radiological aspects of complications such as heterotopic ossification, periprosthetic fractures, osteolysis, infection, wear, and dislocation.
Background: The C reactive protein (CRP) is one of the most accurate inflammatory
markers in acute appendicitis (AA). Obesity leads to a pro-inflammatory
state with increased CRP, which may interfere with the interpretation of
this laboratory test in AA. Aim: To assess sensitivity, specificity, positive predictive value (PPV), and
negative predictive value (NPV) of CRP in patients with AA and their
correlation to body mass index (BMI) and body fat composition. Method: This is a retrospective study based on clinical records and imaging studies
of 191 subjects with histopathologically confirmed AA compared to 249
controls who underwent abdominal computed tomography (CT). Clinical and
epidemiological data, BMI, and CRP values were extracted from medical
records. CT scans were assessed for AA findings and body composition
measurements. Results: CRP values increased according to patients’ BMI, with varying sensitivity
from 79.78% in subjects with normal or lean BMI, 87.87% in overweight, and
93.5% in individuals with obesity. A similar pattern was observed for NPV:
an increase with increasing BMI, 69.3% in individuals with normal or lean
BMI, 84.3% in overweight, and 91.3% in individuals with obesity. There was a
positive correlation between CRP and visceral fat area in patients with AA.
Conclusions: Variations exist for sensitivity, specificity, PPV, and NPV values of CRP in
patients with AA, stratified by BMI. An increase in visceral fat area is
associated with elevated CRP across the BMI spectrum.
Snapping scapula syndrome manifests as an audible or palpable crackling during the sliding movements of the scapula over the rib cage, often perceived during physical or professional activities. It can be caused by morphological alteration of the scapula and rib cage, by an imbalance in periscapular musculature forces (dyskinesia), or by neoplasia (bone tumors or soft tissue tumors). In this pictorial essay, we review the main causes of snapping scapula syndrome, exemplified by a collection of didactic cases.
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