Acute and Subacute Toxicity Studies of Ioversol in Experimental Animals

Ralston, William; Robbins, Mark S.; Coveney, Joseph R.; Blair, Malcolm

doi:10.1097/00004424-198906001-00002

Cited by 25 publications

(12 citation statements)

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“…This is in agreement with other findings (Ralston et al, 1989;Tudury et al, 1997), and supports that ioversol has a low epileptogenic activity. It also reinforces its indication for myelography.…”

Section: Discussionsupporting

confidence: 93%

“…Some researchers have registered a fall in arterial pressure in dogs and humans when ioversol is administered intravascularly (Benamor et al, 1989;Hirshfeld et al, 1989;Ralston et al, 1989). The present results differed in that we found that ioversol 320 mgI/mL significantly increased arterial systolic (PAS) and diastolic pressures (DAP) to values close to initial values.…”

Section: Discussioncontrasting

confidence: 90%

“…There have also been reports of tachycardia (Widmer and Blevins, 1991) and bradycardia (Lewis and Hosgood, 1992) of undetermined origin occurring in dogs that underwent myelography via cerebellomedullary cistern injection of contrast medium, as well as seizures (mainly during recovery from anesthesia (Roberts and Selcer, 1993). More severe symptoms observed were episodes of ventricular arrhythmias and low arterial pressure in humans (Lehmann et al, 1987;Benamor et al, 1989;Hirshfeld et al, 1989) and dogs (Ralston et al, 1989;Wheeler and Sharp, 1999).…”

Section: Introductionmentioning

confidence: 98%

“…Several studies have confirmed its high diagnostic quality (McClennan and Bettmann, 1989) and low neurotoxicity (Ralston et al, 1989;Doucet and Idée, 1992;Wible et al, 1995). Looking at alterations in synaptic transmission within the central nervous system (CNS), researchers have found satisfactory results that indicate that ioversol has low epileptogenic activity (Wible et al, 1995;La Noce et al, 1996;Frigeni et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol

Silva

Tudury

Albuquerque

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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Subarachnoid infusion of most contrast mediums and the steps involved in performing a cervical myelography have adverse affects that can discourage its use in the radiographic diagnosis of spinal cord diseases. Thus, the cardiovascular and respiratory alterations associated with neck flexion, subarachnoid puncture, and cerebrospinal fluid drainage during subarachnoid infusion of ioversol (320mgI/mL) in dogs under general anesthesia using isoflurane were evaluated. The dogs received subarachnoid infusion of autologous cerebrospinal fluid kept at 38°C -control group (GC); ioversol 0.3mL/kg at 25°C (GI25) and ioversol 0.3mL/kg heated to 38°C (GI38). Each dog had its heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), respiratory rate (RR), oxyhemoglobin saturation (SaO 2 ) and electrocardiography readings (PR and QT intervals) recorded. Group comparisons showed no statistical difference regarding neck positioning, subarachnoid puncture, and subarachnoid infusion of contrast medium on HR, RR and SaO 2 , cardiac rhythm or conduction. However, isoflurane significantly increased PR and QT intervals. Based on these findings, it is concluded that the steps involved in cervical myelography and the use of ioversol 320mgI/mL at 0.3mL/kg (25ºC and 38ºC) during cervical myelography did not result in relevant cardiovascular and respiratory alterations, except for an elevation in arterial pressure after injection of ioversol.Keywords: dog, myelography, optiray 320, cardiac arrhythmia, arterial pressure mielografia, optiray 320, arritmia cardíaca, pressão arterial RESUMO Os efeitos adversos provocados pela infusão subaracnoidea de meios de contraste e da mielografia cervical podem desencorajar sua aplicação como alternativa para o diagnóstico radiológico de doenças da medula espinhal. Assim, avaliaram-se os efeitos cardiovascular e respiratório dos procedimentos técnicos necessários à mielografia cervical e da infusão subaracnoidea do ioversol -320mgI/mL -em cães anestesiados com isofluorano. Foi realizada infusão do líquido cefalorraquidiano autólogo mantido a 38°C -grupo-controle (GC); infusão do ioversol 0,3mL/kg a 25°C (GI25); e infusão do ioversol 0,3mL/kg aquecido a 38°C (GI38). Estudaram-se: pressões arteriais sistólica (PAS) e diastólica (PAD), frequências cardíaca (FC) e respiratória (FR), saturação de oxi-hemoglobina (SaO 2 ) e medidas eletrocardiográficas (intervalos PR e QT

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 90%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol

Silva

Tudury

Albuquerque

et al. 2013

Arq. Bras. Med. Vet. Zootec.

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“…All deaths occurred after apnea, during or up to 2 min after the application of the substance. Similar to data found in this study, regarding the interval between administration of the CM and death, there is an article using in the same species comparing iohexol and other CMs, where all deaths occurred immediately after injection (RALSTON et al, 1989). However, there are other articles reporting up to 4 h (LUZZANI et al, 1996), and varying between 10 min to 24 h after administration (WIBLE et al, 1995).…”

Section: Resultssupporting

confidence: 82%

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Mello

Stédile

Gouvêa

et al. 2017

SCA

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Iobitridol is a tri-iodinated contrast agent, and neurotoxicologic studies of the intracisternal administration are scarce and inconclusive. The purpose of this study was to compare the neurotoxicity of iobitridol with iohexol, by intracisternal administration in Wistar rats, for a pre-clinical evaluation of its use as a myelographic agent. The animals, a total of 75, were divided into three experimental groups, iobitridol, iohexol and cerebral artificial fluid (control group), with 25 animals per group. Then, these were divided into five subgroups of five animals each, and given doses of 200, 400, 600, 800 and 1000 mg kg -1 , while the control group received the equivalent volumes of contrast media tested. The animals were evaluated after 5, 15, 30, 60, 120, 180 and 240 min of intracisternal administration of these substances, for signs of depression and excitement, tactile palmar grasp, flexor, extensor, palpebral, papillary and pinna reflexes, surface righting and placing reactions, and with an auditory startle test. The evaluations were assessed daily for seven days with these parameters and their body weight, food, and water intake were also measured. There were no statistically significant differences between groups tested with respect to any of the evaluated parameters. In other words, in this animal model, the iobitridol demonstrated a low neurotoxicologic potential, comparable to that observed with iohexol. Further study with dogs and cats, as an alternative, is suggested. Key words: Contrast media. Cistern. Iodinated contrast. Myelography. Toxicity. ResumoO iobitridol é um meio de contraste tri-iodado, e estudos referentes à neurotoxicidade, com administração subaracnóide são escassos e inconclusivos. O objetivo deste trabalho foi comparar a neurotoxicidade do iobitridol com a do iohexol, por via intracisternal, em ratos Wistar, como avaliação pré-clínica da utilização deste como agente mielográfico. Foram utilizados 75 animais divididos em três grupos experimentais com 25 animais: iobitridol, iohexol e líquido cerebroespinhal artificial (grupo controle). Estes foram subdivididos em cinco subgrupos com cinco animais cada, com doses distintas de 200, 400, 600, 800 e 1000 mg kg -1 , sendo utilizado no grupo controle o volume equivalente aos meios de contraste testados. Os animais foram avaliados após 5, 15, 30, 60, 120, 180 palmar, flexor, extensor, palpebral, pupilar e da pina, reação de endireitamento e posicionamento e resposta auditiva. Nos sete dias subsequentes, os animais foram avaliados diariamente quanto a estes parâmetros, e ainda a massa corporal, a ingestão de ração e de água, foram mensuradas. Não foram observadas diferenças estatisticamente significativas entre os grupos testados com meios de contraste, em nenhum dos parâmetros avaliados. Dessa forma, nesse modelo animal, o iobitridol demonstrou baixa neurotoxicidade, comparável a observada com o iohexol. Sugerem-se mais estudos com cães e gatos para utilização do iobitridol como alternativa. . Palavras-chave: Cisterna. Contraste ...

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Radiopaques

Lin

2000

Kirk-Othmer Encyclopedia of Chemical Technology

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Lin, Youlin (Mallinckrodt Medical, Inc.). Medical examination of soft tissues or organs by nonsurgical means often requires the introduction of a special agent that makes the detection system responsive to detail in the tissue of interest. Radiopaques, often called x‐ray contrast media, are examples of such diagnostic agents. Radiopaques are categorized according to specific applications, such as angiography, urography, myelography, cholecystography, cholangiography, gastrointestinal radiography, computed tomography, arthrography, and hysterosalpingography. The importance, chemistry, and kinds of radiopaques developed for the types of medical imaging are presented. The evolution of research efforts from high osmolality contrast media (HOCM) to low osmolality contrast media (LOCM) is emphasized. Historical perspectives, cost considerations, and future outlooks in contrast media development are briefly outlined. Physical constants, such as osmolality, water solubility, viscosity and partition coefficient, and median lethal dose in animal studies are cited and compared for selected contrast agents. Sources are listed for commercial radiopaque suppliers in the United States. Vol. 20, pp. 906–930, 129 refs. to December 1995.

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Acute and Subacute Toxicity Studies of Ioversol in Experimental Animals

Cited by 25 publications

References 0 publications

Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol

Cardiovascular and respiratory alterations in dogs during cervical myelography using ioversol

Comparative neurotoxicity of iobitridol with iohexol by intracisternal administration in Wistar rats

Radiopaques

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