Acute and Impaired Wound Healing

Demidova-Rice, Tatiana N.; Hamblin, Michael R.; Herman, Ira M.

doi:10.1097/01.asw.0000416006.55218.d0

Cited by 538 publications

(217 citation statements)

References 81 publications

Supporting

Mentioning

211

Contrasting

Unclassified

Order By: Relevance

“…The inflammatory response following tissue injury plays important roles both in normal and pathological healing processes 19 . It provides protection against invading pathogens and remove damaged tissues 20 .…”

Section: ■ Discussionmentioning

confidence: 99%

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

et al. 2017

View full text Add to dashboard Cite

Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuatesinflammatory responses in cutaneous wound healing in mice 1 AbstractPurpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods:The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/ vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-β-D-glucosaminidase activities. The levels of TNF-α, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results:We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In recent decades, clini cians have gained a better understanding of the mechanisms of normal wound repair process and causes of delays in healing. 2 However, some cutaneous wounds involves complex inflammatory processes, which can lead to a more aggressive state and take longer time resulting in chronic state of inflammation. 3 Diabetic wounds are complex wounds appear as cuta neous complications arise from uncontrolled diabetes mellitus caused by hyperglycemia, oxidative stress and /or microbial infections.…”

Section: Introductionmentioning

confidence: 99%

The Role of Pomelo Peel Extract for Experimentally Induced Wound in Diabetic Rats

Ahmad¹,

Khalifa²,

Abudayeh³

2018

View full text Add to dashboard Cite

Introduction:Delayed wound healing is a chronic complication in diabetic patients than in healthy individuals. Pomelo belongs to the genus Citrus of the family Rutaceae, an important fruit with great benefits for humans in the world. Previous studies showed that pomelo peels contain an abundant bioactive compound, which may promote wound healing in experimental animals. Aim: The current study was carried to prepare optimized extraction of pomelo peels using different experimental conditions and investigate the possible healing effect of oral treatment with pomelo peel extract (PPE) on induced excision skin wound in diabetic rats. Materials and Methods: This study was done on rats divided into five groups each of 8 rats (two treatment groups given PPE (400 and 600) mg/kg by oral gavage compared to two control groups and standard plant for wound healing). Diabetes was induced by intraperitoneal injection of a single dose of Streptozotocin (STZ) 65 mg\kg body weight. After diabetes induction, full thickness excision wound was made in rats, and the study continued for 3 weeks. Results: This study showed significant reduction in blood glucose and both percentage and time to wound closure in the treated groups, also a significant increase in hydroxyproline and total protein content of the healed wound tissue in the treated groups compared with control groups and comparable to standard plant extract treated groups. Conclusion: Experimental data proposed that oral administration of pomelo peel extract rich in vitamins and flavonoids has a good therapeutic potential in the treatment of complicated wounds in diabetes.

show abstract

“…In vitro studies revealed that pulegone is a selective COX-2 inhibitor (24). Although no mechanism of action has been investigated, probably pulegone acts through the inhibition of the production of inflammatory mediators from the cascade of cyclooxygenase.…”

Section: Discussionmentioning

confidence: 99%

Planimetric and Biomechanical Study of Local Effect of Pulegone on Full Thickness Wound Healing in Rat

Cheraghali

Mohammadi

Jalilzadeh-Amin

2017

MJMS

View full text Add to dashboard Cite

Background: Pulegone as principal component of essential oil, reported to have antibacterial, antioxidant and anti-inflammatory properties. The present study was aimed to evaluate wound healing activity of pulegone in a rat model.Method: Forty rats were used for excisional and incisional wound healing models. For each model twenty male white Wistar rats were randomly divided into five groups (n = 4) of control (CG), Sham surgery, E1, E2 and E3. Wound size, hydroxyproline content of wound and biomechanical testing were assessed.Result: In E2 animals, the wound size was reduced earlier than in E1 and E2 groups (P = 0.035). However, time had significant effect on wound contraction of all wounds. Hydroxyproline contents in the groups CG, sham surgery, E1, E2 and E3 were found to be 51.25 ± 3.40, 58.41 ± 4.62, 68.59 ± 3.53, 86.32 ± 3.18, and 74.26 ± 4.73 mg g -1 , respectively. Hydroxyproline contents were increased significantly in E2 compared to E1 and E3 which implied more collagen deposition compared to other experimental groups (P = 0.001). The biomechanical indices, maximum stored energy, stiffness, ultimate strength and yield strength obtained for E2 group were significantly higher than those obtained for E1 and E2 groups (P = 0.002).Conclusion: The pulegone showed a reproducible wound healing potential in rats.

show abstract

Acute and Impaired Wound Healing

Cited by 538 publications

References 81 publications

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

The Role of Pomelo Peel Extract for Experimentally Induced Wound in Diabetic Rats

Planimetric and Biomechanical Study of Local Effect of Pulegone on Full Thickness Wound Healing in Rat

Contact Info

Product

Resources

About