2017
DOI: 10.21315/mjms2017.24.5.6
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Planimetric and Biomechanical Study of Local Effect of Pulegone on Full Thickness Wound Healing in Rat

Abstract: Background: Pulegone as principal component of essential oil, reported to have antibacterial, antioxidant and anti-inflammatory properties. The present study was aimed to evaluate wound healing activity of pulegone in a rat model.Method: Forty rats were used for excisional and incisional wound healing models. For each model twenty male white Wistar rats were randomly divided into five groups (n = 4) of control (CG), Sham surgery, E1, E2 and E3. Wound size, hydroxyproline content of wound and biomechanical test… Show more

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Cited by 4 publications
(6 citation statements)
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“…The Pulegone was procured from Sigma Chemical Co, USA. Based on previous acute toxicological reports of pulegone, 20 mg/kg body weight of pulegone was prepared to be nontoxic for rats [10].…”
Section: Methodsmentioning
confidence: 99%
“…The Pulegone was procured from Sigma Chemical Co, USA. Based on previous acute toxicological reports of pulegone, 20 mg/kg body weight of pulegone was prepared to be nontoxic for rats [10].…”
Section: Methodsmentioning
confidence: 99%
“…Dexpanthenol is a vitamin B5 -well-known substance in the world for tissues regeneration stimulating. 21,22 Stencil wounds 23 of the back were simulated in animals under anesthesia with diethyl ether. The initial wound size was 4 ± 1.0 cm 2 .…”
Section: Determining the Influence Of D1 And D2 Aerosols On Stencil Wmentioning
confidence: 99%
“…Then, the animals were fixed for 30 minutes to ensure the absorption of the solution and to prevent them from licking wounds. A planimetric study 23 was conducted on the 3rd, 7th, 10th, 14th and 18th day from the beginning of the experiment. The obtained parameters of the wound surface area were statistically processed using the analysis of variance.…”
Section: Determining the Influence Of D1 And D2 Aerosols On Stencil Wmentioning
confidence: 99%
“…The animals were divided into four groups: 1wounds treated with D1 aerosol (n = 10); 2wounds treated with D2 (n = 10); 3wounds treated with the reference drug dexpanthenol (Panthenol-Ratiopharm, 5% ointment) (n = 10); 4control group (n = 8). Dexpanthenol is a vitamin B5 -well-known substance in the world for tissues regeneration stimulating [24,25] Stencil wounds [26] of the back were simulated in animals under anesthesia with diethyl ether. The initial wound size was 4 ± 1.0 cm 2 .…”
Section: Determining the Influence Of D1 And D2 Aerosols On Stencil Wmentioning
confidence: 99%
“…Then, the animals were fixed for 30 minutes to ensure the absorption of the solution and to prevent them from licking wounds. A planimetric study [26] was conducted on the 3rd, 7th, 10th, 14th and 18th day from the beginning of the experiment. The obtained parameters of the wound surface area were statistically processed using the analysis of variance.…”
Section: Determining the Influence Of D1 And D2 Aerosols On Stencil Wmentioning
confidence: 99%