The Role of Pomelo Peel Extract for Experimentally Induced Wound in Diabetic Rats

Abstract

Introduction:Delayed wound healing is a chronic complication in diabetic patients than in healthy individuals. Pomelo belongs to the genus Citrus of the family Rutaceae, an important fruit with great benefits for humans in the world. Previous studies showed that pomelo peels contain an abundant bioactive compound, which may promote wound healing in experimental animals. Aim: The current study was carried to prepare optimized extraction of pomelo peels using different experimental conditions and investigate the possible healing effect of oral treatment with pomelo peel extract (PPE) on induced excision skin wound in diabetic rats. Materials and Methods: This study was done on rats divided into five groups each of 8 rats (two treatment groups given PPE (400 and 600) mg/kg by oral gavage compared to two control groups and standard plant for wound healing). Diabetes was induced by intraperitoneal injection of a single dose of Streptozotocin (STZ) 65 mg\kg body weight. After diabetes induction, full thickness excision wound was made in rats, and the study continued for 3 weeks. Results: This study showed significant reduction in blood glucose and both percentage and time to wound closure in the treated groups, also a significant increase in hydroxyproline and total protein content of the healed wound tissue in the treated groups compared with control groups and comparable to standard plant extract treated groups. Conclusion: Experimental data proposed that oral administration of pomelo peel extract rich in vitamins and flavonoids has a good therapeutic potential in the treatment of complicated wounds in diabetes.

Acute toxicity and anti-hyperglycemic activities of pomelo (Citrus grandis (L.) Osbeck) peel extracts in the Mekong Delta of Vietnam

“…The elevation of glucose level was ascribed to the insufficient insulin secretion, insensitivity of insulin, preventing the diffusion of glucose to muscle cells, leading to the decrement in glucose utilization (Chandalia et al, 2000). Blood glucose level of non-treated mice was found to gradually increase during the observed period, which was in agreement with previous study (Ahmad et al, 2018) 2018) revealed the similar finding in PPE to reduce elevated blood glucose levels. This anti-hyperglycemic effect was also found in other citrus peel extracts (Ahmed et al, 2017;Ali et al, 2020;Fayek et al, 2017).…”

Accelerative Wound-Healing Effect of Aqueous Anthocephalus Cadamba Leaf Extract in a Diabetic Rat Model

“…Interestingly, antioxidant deficiencies also result in delayed wound healing and are linked to decreased collagen biosynthesis and decreased angiogenesis. 29 Studies reported that the antioxidant properties of A. cadamba species could increase collagen deposition and prevent its degradation. This explains increased hydroxyproline content and dry granulation tissue weight in extract-treated wounds.…”

Chemical Content and Pharmacology of Pomelo Orange (Citrus Maxima) Fruit Peel: A Review

“…The results showed a significant decrease in blood glucose levels, as well as a significant improvement in wound closure percentage and time in the treatment groups. There was also a significant increase in hydroxyproline and total protein content in the healed wound tissue of the treatment groups compared to the control groups, and this was comparable to the standard plant extract [19]. Additionally, an ethanol extract of pomelo albedo was tested to reduce blood glucose levels in rats induced with aloxan-induced hyperglycemia (from 350 mg/dL to 150 mg/dL).…”