2018
DOI: 10.5530/pj.2018.5.149
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The Role of Pomelo Peel Extract for Experimentally Induced Wound in Diabetic Rats

Abstract: Introduction:Delayed wound healing is a chronic complication in diabetic patients than in healthy individuals. Pomelo belongs to the genus Citrus of the family Rutaceae, an important fruit with great benefits for humans in the world. Previous studies showed that pomelo peels contain an abundant bioactive compound, which may promote wound healing in experimental animals. Aim: The current study was carried to prepare optimized extraction of pomelo peels using different experimental conditions and investigate the… Show more

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Cited by 7 publications
(3 citation statements)
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“…The elevation of glucose level was ascribed to the insufficient insulin secretion, insensitivity of insulin, preventing the diffusion of glucose to muscle cells, leading to the decrement in glucose utilization (Chandalia et al, 2000). Blood glucose level of non-treated mice was found to gradually increase during the observed period, which was in agreement with previous study (Ahmad et al, 2018) 2018) revealed the similar finding in PPE to reduce elevated blood glucose levels. This anti-hyperglycemic effect was also found in other citrus peel extracts (Ahmed et al, 2017;Ali et al, 2020;Fayek et al, 2017).…”
Section: Anti-hyperglycemic Effect Of Ppe In Vivosupporting
confidence: 90%
“…The elevation of glucose level was ascribed to the insufficient insulin secretion, insensitivity of insulin, preventing the diffusion of glucose to muscle cells, leading to the decrement in glucose utilization (Chandalia et al, 2000). Blood glucose level of non-treated mice was found to gradually increase during the observed period, which was in agreement with previous study (Ahmad et al, 2018) 2018) revealed the similar finding in PPE to reduce elevated blood glucose levels. This anti-hyperglycemic effect was also found in other citrus peel extracts (Ahmed et al, 2017;Ali et al, 2020;Fayek et al, 2017).…”
Section: Anti-hyperglycemic Effect Of Ppe In Vivosupporting
confidence: 90%
“…Interestingly, antioxidant deficiencies also result in delayed wound healing and are linked to decreased collagen biosynthesis and decreased angiogenesis. 29 Studies reported that the antioxidant properties of A. cadamba species could increase collagen deposition and prevent its degradation. This explains increased hydroxyproline content and dry granulation tissue weight in extract-treated wounds.…”
Section: Discussionmentioning
confidence: 99%
“…The results showed a significant decrease in blood glucose levels, as well as a significant improvement in wound closure percentage and time in the treatment groups. There was also a significant increase in hydroxyproline and total protein content in the healed wound tissue of the treatment groups compared to the control groups, and this was comparable to the standard plant extract [19]. Additionally, an ethanol extract of pomelo albedo was tested to reduce blood glucose levels in rats induced with aloxan-induced hyperglycemia (from 350 mg/dL to 150 mg/dL).…”
Section: Antidiabetic Activitymentioning
confidence: 72%