Acute and chronic toxicity studies of Erythrina senegalensis DC stem bark extract in mice

Udem, Samuel Chukwuneke; Obidoa, Onyechi; Asuzu, Isaac Uzoma

doi:10.1007/s00580-009-0852-5

Cited by 21 publications

(15 citation statements)

References 8 publications

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“…This hypothesis was comforted by the histopathological analysis of the liver which show no alteration in the liver structure of EAES treated rats and is in accordance with previous studies which showed hepatoprotective effects of the extract and components isolated from the stem bark of Erythrina senegalensis (Njayou et al, 2004;Donfack et al, 2008aDonfack et al, , 2008b. However, these results are in contradiction with those obtained by Udem et al (2009) when studying the acute and chronic toxicity of chloroform stem bark extract of Erythrina senegalensis in mice. When incorporated in mice food at the dose of 1 g/kg in chronic study (84 days), increases in the activities of alanine amino transferase, aspartate amino transferase, and alkaline phosphatase were observed while red blood cell count significantly decreased.…”

Section: Parameterscontrasting

confidence: 84%

“…Many pharmacological works have demonstrated the antimicrobial (Koné et al, 2004;Magassouba et al, 2007), antiplasmodial, analgesic and antiinflammatory (Saidu et al, 2000) and the hepatoprotective and antioxidant (Donfack et al, 2008a) effects of extracts from the stem bark of ES. Recently, the acute and chronic toxicity studies of ES chloroform stem bark have been investigated (Udem et al, 2009). In spite of this, none is known about the toxic effects of the widely traditionally used decoction of the ES stem bark.…”

Section: Introductionmentioning

confidence: 99%

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Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents

Atsamo

Nguelefack

Datté

et al. 2011

Journal of Ethnopharmacology

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Section: Parameterscontrasting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents

Atsamo

Nguelefack

Datté

et al. 2011

Journal of Ethnopharmacology

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“…Other studies reported the presence of alkaloids, flavonoids, polyphenols and reducing sugars. The presence of such biological molecules attempt to justify some of the ethno-medicinal applications of E. senegalensis [11][12][13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Analysis and Acute Toxicological Study of Erythrina senegalensis Ethanolic Leaf Extract in Albino Wistar Rats

Tn¹,

Al²,

Rn³

et al. 2016

Anat Physiol

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Objective: Erythrina senegalensis is used to cure wide range of illnesses such as malaria, gastrointestinal disorders, fever, dizziness, asthma. Given its widespread usage, the study sought to investigate the phytochemical analysis and acute oral toxicity (LD50) of E. senegalensis. Materials and methods:Fresh mature leaf samples of E. senegalensis were collected and phytochemical analysis was carried out appropriately. The acute toxicity study of the leaf extract was determined using modified Lorke's method. Thirteen adult Wistar rats of both sexes were acclimatized, nine of which were used for the first phase of treatment, and the other four were used for the second phase of acute toxicity testing, while being closely monitored for mortality.Results: Alkaloids, saponins and flavonoids, were found in moderate quantities; tannins and terpenoids were found in trace amounts, while cardiac glycosides and steroids were not found. The acute oral toxicity of E. senegalensis was greater than 5000 mg/kg of the experimental rats (LD50>5000 mg/kg).Conclusion: E. senegalensis possesses many useful phytoconstituents that contribute to the potency of leaf extract and which made it useful in treatment of many diseases, and that E. senegalensis ethanolic leaf extract has low toxicity in rats, especially when administered orally.

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“…These compounds are isolated and analyzed to determine biological activity, mechanisms of action, and toxicity [1, 2]. The genus Stryphnodendron sp belongs to the family Fabaceae (native savanna), approximately 48 species of which have been identified, including Stryphnodendron adstringens (Mart.)…”

Section: Introductionmentioning

confidence: 99%

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

Costa

Mello

Kaneshima

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015 mg · kg−1. In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200 mg · kg−1). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.

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Acute and chronic toxicity studies of Erythrina senegalensis DC stem bark extract in mice

Cited by 21 publications

References 8 publications

Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents

Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents

Phytochemical Analysis and Acute Toxicological Study of Erythrina senegalensis Ethanolic Leaf Extract in Albino Wistar Rats

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark ofStryphnodendron adstringens(Barbatimão) in Rodents

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