Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents

Atsamo, Albert Donatien; Nguelefack, Télesphore Benoît; Datté, Jacques Y; Kim, Albert

doi:10.1016/j.jep.2011.01.023

Cited by 73 publications

(58 citation statements)

References 26 publications

(25 reference statements)

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“…The study reveals that following the oral administration of leaf extract of Erytherina senegalensis that there was a significant difference in the body weight of the albino rats at doses of 8000 mg/kg (Group iv) from the 4th week to 8th week (Table 3), this may show that the extract may not be toxic, although there was a decline in the fluid and food intakes from week 2 (Tables 1 and 2), The weights and relative organ weights of the ovaries of experimental rats showed no significant difference when compared with the control, which signifies that the leaf extract of Erytherina senegalensis may be nutritional and not toxic on the albino rats and the research agreed with that there were no significant changes in the relative weights of organs between the control and treated rats [13].…”

Section: Discussionsupporting

confidence: 55%

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

Tn¹,

Dn²,

Cs³

et al. 2017

Anat Physiol

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Erytherina senegalensis are used in soups administered after delivery, also in Nigeria; it is given to women during labour to ease pain, for treatment of malaria, gastrointestinal disorders, fever, dizziness, secondary sterility, diarrhoea, jaundice, nose bleeding, pain, bronchial infection, coughs, throat inflammation and administered for venereal diseases. In view of its usage, the study sought to investigate the effect of Erytherina senegalensis leaf extract on the oestrogen level and the histology of the ovary of albino wistar rat. Fresh mature leaf samples of E. senegalensis were collected, ethanolic extract was prepared and the effect of sub-chronic oral administration of the leaf extract of E. senegalensis was studied using twenty-five female albino wistar rats. The oral administration of the leaf extract was done three times per week, for 60 days at doses of 2000 mg/kg for group 1, 4000 mg/kg for group 2, 6000 mg/kg for group 3, 8000 mg/kg body weight for group 4 and group 5 is the control group, received distilled water and food alone. The rats were anaesthetised by chloroform in a close jar and blood samples were for hormonal test, experimental rats were sacrificed by cervical dislocation and the ovary harvested. There was a dose dependent increase in the level of oestrogen across the groups and there was no significant alteration on the histology of the ovary across the groups. Oestrogen level and histology architecture reveals the leaf extract didn't show any sign of toxicity on the hormone and organ of the study, this may suggest that the extract may be used as female hormonal supplement and may not be toxic when administered orally.

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Section: Discussionsupporting

confidence: 55%

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

Tn¹,

Dn²,

Cs³

et al. 2017

Anat Physiol

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“…All treatment was given by oral route once a day for 28 days [24]. The animals were observed for signs of toxicity (mortality, nervousness, and other physiological changes) during the experimental period.…”

Section: Sub-chronic Toxicity Testmentioning

confidence: 99%

Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Onyeka¹,

Сулейман²,

Bako³

2018

J Pharmacogn Nat Prod

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The Igbo people of the South-eastern part of Nigeria claims that a combination of Ehirta and honey has therapeutic effect for Ulcer. The study was designed to scientifically evaluate the phytochemical composition of E. hirta and the safety of the phytomedicine. Nine hundred gram (900 g) of E. hirta gave an average yield of 49.05 g of the extract and this gave percentage yield of 5.45% when extracted with continuous extraction process of Soxhlet apparatus. Phytochemical screenings of E. hirta showed that the extract contains alkaloids, Tannins, Saponins, Glycosides, Flavonoids and Unsaturated steroids. Acute toxicity studies showed that LD 50 was greater than 5000 mg/kg. The phytomedicine of E. hirta combined with did not produce significant changes in the blood biochemical and haematological parameters. Though slight reductions were witnessed in blood ALT the phytomedicine drugs has no significant effect on the liver and other vital organs like the kidney, the heart, spleen, intestine and the brain except the lungs that witnessed slight alveoli congestion. The study revealed that E. hirta combined with honey is safe for consumption.

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“…The animal study was performed with approval of the Institutional Animal Ethics Committee (AEC) of Jadavpur University, Kolkata, India on 7 September 2012 (Project Identification Code: Utilization of Slaughterhouse Wastes as an Organic Fertilizer for the Cultivation of Tomatoes). Growth, hematological parameters, relative organ weights and histological parameters of Wistar rats fed with BBRDM-grown tomatoes for 28 days was compared with the results obtained from the control rats fed with water [85]. A total of 24 male and female Wistar rats of 2 months age (male, 130-150 g; female, 150-170 g) were used for the toxicological studies.…”

Section: Sub-acute Toxicity Study Of Tomatoes Grown With Bbrdmmentioning

confidence: 99%

“…During the course of the study, cage side observations included examination of skin, fur, eyes, respiratory and autonomic effects like salivation, urination as well as central nervous system effects such as tremors and convulsions, changes in the level of activity, gait and posture. The behavior of the rats was noted daily and their weights and mean food consumption were recorded once every week [85,87,88]. On the 28th day, blood pressures of all the rats were measured and on the 29th day after an overnight fast, blood from each animal was collected by retro-orbital bleeding for hematological and biochemical tests described before.…”

Section: Sub-acute Toxicity Study Of Tomatoes Grown With Bbrdmmentioning

confidence: 99%

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

et al. 2015

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Environmental and health safety of recycled slaughterhouse wastes-derived fertilizer and the produce obtained through its application is not well understood. Waste bovine blood and rumen digesta were mixed, cooked and sun-dried to obtain bovine-blood-and-rumen-digesta-mixture (BBRDM, NPK 30.36:1:5.75). 1.26 ± 0.18 log CFU mL −1 fecal coliforms were recovered in BBRDM. E. coli O157:H7, Mycobacteria, Clostridium sp., Salmonella sp., Bacillus sp. and Brucella sp. were absent. No re-growth of pathogens was observed after 60 days storage in sealed bags and in the open. However, prions and viruses were not evaluated. Heavy metals (Pb, Cr, Cd, Cu, Zn, As, Ni, Mn) concentrations in BBRDM were within internationally permissible limits. BBRDM was applied for field cultivation of tomato during 2012-2013 and 2013-2014. Lycopene and nitrate contents of BBRDM-grown tomatoes were higher than Diammonium OPEN ACCESSAgriculture 2015, 5 827 phosphate (DAP) + potash-grown tomatoes because BBRDM supplied 2.5 times more the amount of nitrogen than DAP (NPK 18:46:0) + potash (NPK 0:0:44). Heavy metals and nitrate/nitrite concentrations in tomatoes were within internationally acceptable limits. BBRDM-grown tomatoes showed no mutagenic activity in the Ames test. Sub-acute toxicity tests on Wistar rats fed with BBRDM-grown tomatoes did not show adverse clinical picture. Thus, no immediate environmental or health risks associated with BBRDM and the tomatoes produced were identified.

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Acute and subchronic oral toxicity assessment of the aqueous extract from the stem bark of Erythrina senegalensis DC (Fabaceae) in rodents

Cited by 73 publications

References 26 publications

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

Effect of Erytherina senegalensis on the oestrogen level and histology of ovary of an adult female albino wistar rats

Toxicity Effects of Methanolic Extract of Euphorbia hirta-Honey Mixture in Albino Rats

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

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