Acute and Chronic Role of 5-HT3 Neuronal System on Behavioral and Neuroendocrine Changes Induced by Intravenous Cholecystokinin Tetrapeptide Administration in Humans

Depot, Michelle; Caillé, Gilles; Mukherjee, Jayanti; Katzman, Martin A.; Cadieux, Alain; Bradwejn, Jacques

doi:10.1016/s0893-133x(98)00074-8

Cited by 29 publications

(4 citation statements)

References 28 publications

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“…However, little is known on the role of peripheral serotonin in the regulation of feeding behavior. The effects of serotonin on appetite regulation are mediated by multiple receptor subtypes, including 5-hydroxytryptamine type 3 (5HT3) receptors [ 28 , 31 ]. It is unknown whether peripheral 5HT3 receptors are essential for feed intake regulation in LBW pigs fed with Trp-enriched diets.…”

Section: Introductionmentioning

confidence: 99%

Dietary Tryptophan Supplementation Alters Fat and Glucose Metabolism in a Low-Birthweight Piglet Model

et al. 2021

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Low birthweight (LBW) is associated with metabolic complications, such as glucose and lipid metabolism disturbances in early life. The objective of this study was to assess: (1) the effect of dietary tryptophan (Trp) on glucose and fat metabolism in an LBW piglet model, and (2) the role peripheral 5-hydroxytryptamine type 3 (5HT3) receptors in regulating the feeding behavior in LBW piglets fed with Trp-supplemented diets. Seven-day-old piglets were assigned to 4 treatments: normal birthweight-0%Trp (NBW-T0), LBW-0%Trp (LBW-T0), LBW-0.4%Trp (LBW-T0.4), and LBW-0.8%Trp (LBW-T0.8) for 3 weeks. Compared to LBW-T0, the blood glucose was decreased in LBW-T0.8 at 60 min following the meal test, and the triglycerides were lower in LBW-T0.4 and LBW-T0.8. Relative to LBW-T0, LBW-T0.8 had a lower transcript and protein abundance of hepatic glucose transporter-2, a higher mRNA abundance of glucokinase, and a lower transcript of phosphoenolpyruvate carboxykinase. LBW-T0.4 tended to have a lower protein abundance of sodium-glucose co-transporter 1 in the jejunum. In comparison with LBW-T0, LBW-T0.4 and LBW-T0.8 had a lower transcript of hepatic acetyl-CoA carboxylase, and LBW-T0.4 had a higher transcript of 3-hydroxyacyl-CoA dehydrogenase. Blocking 5-HT3 receptors with ondansetron reduced the feed intake in all groups, with a transient effect on LBW-T0, but more persistent effect on LBW-T0.8 and NBW-T0. In conclusion, Trp supplementation reduced the hepatic lipogenesis and gluconeogenesis, but increased the glycolysis in LBW piglets. Peripheral serotonin is likely involved in the regulation of feeding behavior, particularly in LBW piglets fed diets supplemented with a higher dose of Trp.

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Section: Introductionmentioning

confidence: 99%

Dietary Tryptophan Supplementation Alters Fat and Glucose Metabolism in a Low-Birthweight Piglet Model

et al. 2021

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“…Indeed, in patients with panic disorder and social phobia, ondansetron fails to prevent the anxiety induced by pentagastrin, a CCK agonist [205]. Whereas, in healthy volunteers, ondansetron prevents panic symptoms induced by CCK tetrapeptide [206]. …”

Section: -Ht3 Receptors As Drug Target For Treatment Of Anxiety and mentioning

confidence: 99%

Role of 5-HT3 Receptors in the Antidepressant Response

et al. 2011

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Serotonin (5-HT)3 receptors are the only ligand-gated ion channel of the 5-HT receptors family. They are present both in the peripheral and central nervous system and are localized in several areas involved in mood regulation (e.g., hippocampus or prefrontal cortex). Moreover, they are involved in regulation of neurotransmitter systems implicated in the pathophysiology of major depression (e.g., dopamine or GABA). Clinical and preclinical studies have suggested that 5-HT3 receptors may be a relevant target in the treatment of affective disorders. 5-HT3 receptor agonists seem to counteract the effects of antidepressants in non-clinical models, whereas 5-HT3 receptor antagonists, such as ondansetron, present antidepressant-like activities. In addition, several antidepressants, such as mirtazapine, also target 5-HT3 receptors. In this review, we will report major advances in the research of 5-HT3 receptor's roles in neuropsychiatric disorders, with special emphasis on mood and anxiety disorders.

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“…Recently, many studies have shown that 5-HT 3 receptor is another important 5-HT subtype for modulating feeding behavior [ 1 , 6 – 8 ]. Activation of 5-HT 3 receptor affects many feeding-related neurons, including proopiomelanocortin (POMC) neuron [ 6 ], catecholamine neuron [ 1 ], AgRP neuron [ 7 ] and neuropeptide Y (NPY) neuron [ 8 ]. The 5-HT 3 receptor also plays an important role in interacting with other feeding related peptide-mediated signaling.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, systemic administration of 5-HT reduced sucrose intake in a dose-dependent manner via 5-HT 3 receptor [ 10 ], whereas the selective blockade of 5-HT 3 receptor decreased satiation [ 11 – 13 ]. The cross-talk between 5-HT 3 receptor, CCK and NPY systems has been also evidenced in human [ 8 ]. These results suggest that activation of the 5-HT 3 receptor may be implicated in the inhibitory modulation of feeding behavior.…”

Section: Introductionmentioning

confidence: 99%

Role of 5-HT3 Receptor on Food Intake in Fed and Fasted Mice

Shao

Luo

et al. 2015

PLoS ONE

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BackgroundMany studies have shown that 5-hydroxytryptamine (5-HT) receptor subtypes are involved in the regulation of feeding behavior. However, the relative contribution of 5-HT3 receptor remains unclear. The present study was aimed to investigate the role of 5-HT3 receptor in control of feeding behavior in fed and fasted mice.Methodology/Principal FindingsFood intake and expression of c-Fos, tyrosine hydroxylase (TH), proopiomelanocortin (POMC) and 5-HT in the brain were examined after acute treatment with 5-HT3 receptor agonist SR-57227 alone or in combination with 5-HT3 receptor antagonist ondansetron. Food intake was significantly inhibited within 3 h after acute treatment with SR 57227 in fasted mice but not fed mice, and this inhibition was blocked by ondansetron. Immunohistochemical study revealed that fasting-induced c-Fos expression was further enhanced by SR 57227 in the brainstem and the hypothalamus, and this enhancement was also blocked by ondansetron. Furthermore, the fasting-induced downregulation of POMC expression in the hypothalamus and the TH expression in the brain stem was blocked by SR 57227 in the fasted mice, and this effect of SR 57227 was also antagonized by ondansetron.Conclusion/SignificanceTaken together, our findings suggest that the effect of SR 57227 on the control of feeding behavior in fasted mice may be, at least partially, related to the c-Fos expression in hypothalamus and brain stem, as well as POMC system in the hypothalamus and the TH system in the brain stem.

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Acute and Chronic Role of 5-HT3 Neuronal System on Behavioral and Neuroendocrine Changes Induced by Intravenous Cholecystokinin Tetrapeptide Administration in Humans

Cited by 29 publications

References 28 publications

Dietary Tryptophan Supplementation Alters Fat and Glucose Metabolism in a Low-Birthweight Piglet Model

Dietary Tryptophan Supplementation Alters Fat and Glucose Metabolism in a Low-Birthweight Piglet Model

Role of 5-HT3 Receptors in the Antidepressant Response

Role of 5-HT3 Receptor on Food Intake in Fed and Fasted Mice

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