Acute and chronic anti-inflammatory properties of the stem bark aqueous and methanol extracts of Sclerocarya birrea (Anacardiaceae)

Mostafazadeh

et al. 2013

Pharmaceutical Biology

Context: Nasturtium officinale R. Br. (watercress) has long been used in Iranian folk medicine to treat hypertension, hyperglycemia, and renal colic. Moreover, anticancer, antioxidant, and hepatoprotective properties of N. officinale have been reported. Objective: In this study, anti-inflammatory activity of the hydro-alcoholic extract from aerial parts of N. officinale was investigated. Materials and methods: Oral administration of the hydro-alcoholic extract of N. officinale (250, 500 and 750 mg kg À1) was investigated on two well-characterized animal models of inflammation, including carrageenan-or formalin-induced paw edema in rats. Then, the topical anti-inflammatory effect of N. officinale (2 and 5 mg/ear) was studied on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema. Finally, biopsy of the paw or ear was performed for pathological evaluation. Results: Acute toxicity tests of N. officinale in rats established an oral LD 50 of 45 g kgThe extract of watercress (250, 500 and 750 mg kg À1) significantly inhibited carrageenaninduced paw edema 1, 2, 3 and 4 h after carrageenan challenge (p50.001). The extract (500 mg kg À1) also showed considerable activity against formalin-evoked paw edema over a period of 24 h (p50.001). Furthermore, topical application of N. officinale (5 mg/ear) reduced TPA-induced ear edema (p50.05). Histopathologically, the extract decreased swelling and the tissue damage induced by carrageenan or TPA. Discussion and conclusion: Our findings indicate potent anti-inflammatory activity of N. officinale in systemic and topical application and propose its potential as an anti-inflammatory agent for treatment of inflammatory conditions.

Section: Formalin-induced Edema In the Rat Pawmentioning

confidence: 99%

In vivoanti-inflammatory properties of aerial parts ofNasturtium officinale

Mostafazadeh

et al. 2013

Pharmaceutical Biology

Bayero J. Pure App. Sci.

“…The initial phase which (0-2hours) is mediated by histamine and serotonin release while, the second phase (3 rd hour) is due to liberation of prostaglandins, bradykinins, lysosomes, cyclooxygenase products (Perianayagan et al, 2006;Fotio et al, 2009). The ability of the extract to significantly reduce the inflammatory response induced by carrageenan, suggests its antiinflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Anti inflammatory and antipyretic activities of the methanol leaf extract of <i>Acacia ataxacantha</i> D.C.(Leguminosae) in mice and rats

Abbas¹,

Ejiofor²,

Yaro³

et al. 2017

Acacia ataxacantha (Leguminosae) has been reported to be used in traditional medicine for management of pain and inflammation. The present study was designed to evaluate the anti inflammatory and antipyretic activities of methanol leaf extract of Acacia ataxacantha in rats. The acute toxicity study was carried out using Lorke method (1983). The doses (100, 200 and 400 mg/kg body weight of the extract) selected for the study were based on the calculated LD inflammatory activities were investigated using the carragenaan and albumin induced paw edema, while the antipyretic activity was evaluated using yeast induced pyrexia method. the negative control (group 1), the carragenaan induced inf significant (p ≤ 0.05) reduction of inflammation at 200 and 400 mg/kg (3 ≤ 0.05) reduction in oedema was observed at doses of 100, 200 and 400mg/kg (4 there were significant inhibitions (p minutes post extract administration in albumin induced hind from the antipyretic study showed no significant effect. These findings suggest that the may contain bioactive compounds that possess anti ethno-medical use of the plant in the management of painful inflammation.

“…The absorbance of the supernatant was read at 530 nm using a spectrophotometer. The amount of MDA is expressed as nmol/mg [19].…”

Section: Brain Lipid Peroxidationmentioning

confidence: 99%

Antioxidant Activities of <i>Dichrocephala integrifolia</i> (Linn.f.) O. Kuntze (Asteraceae) in a Mice Model of D-Galactose-Induced Oxidative Stress and Accelerated Aging

Kouémou

Lambou

Nguepi

et al. 2017

IJPPE

Abstract. Dichrocephala integrifolia is a plant widely used in folk medicine in Africa to treat central nervous diseases such as dementia. In the present study, we evaluated the effect of the leave's decoction of Dichrocephala integrifolia against D-galactose-induced neurotoxicity, oxidative stress and accelerated aging in mice. D-galactose (100 mg/ kg sc), was chronically injected daily to mice during 42 consecutive days after pretreatment with distilled water (10 ml/kg) or the decoction of D. integrifolia (35; 87.5; 175 or 350 mg/kg p.o) or vitamin C (100 mg/kg p.o). Following behavioral tasks (Open Field, Elevated Plus Maze and Morris Water Maze), animals were sacrificed on day 43 and their brains were used to evaluate some biochemical parameters of oxidative stress (malondialdehyde, nitrite oxide and reduced glutathione) and for histopathological assessments. The results of this study showed that a pretreatment of animals with the decoction of D. integrifolia at the doses of 87.5 and 175 mg/kg significantly (p˂0.05) reversed learning deficits, recall of memories and oxidative stress induced by D-galactose. The decoction of D. integrifolia also prevented neurogeneration in the dentate gyrus induced by D-galactose. These results indicated that D. integrifolia possesses neuroprotective effects against D-galactose-induced senescence, probably due to its antioxidant capacities and this can at least explain the wide use of this plant in traditional medicine in Cameroon in the prevention and treatment of dementia.