Acute allergic reaction to eugenol

Barkin, Michael E.; Boyd, James; Cohen, Stephen

doi:10.1016/0030-4220(84)90166-x

Cited by 51 publications

(28 citation statements)

References 2 publications

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“…It was found that eugenol-containing dressings showed delayed healing (Kozan and Mantell, 1978), more allergic reactions (Barkin et al, 1984) and more inhibition of fibroblast proliferation (Eber et al, 1989) compared to non-eugenol containing dressings. In the present study the cytotoxic effects of four different non-eugenol periodontal dressings and a viscous tincture on V-79 fibroblast cell culture were studied.…”

Section: Discussionmentioning

confidence: 99%

Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs

Petelin

Pavlica

Batista

et al. 2004

Acta Veterinaria Hungarica

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In the present study the effects of different commercially available periodontal dressings (Peripac, Barricaid, Fittydent, Reso-Pack and Myzotect-tincture) on fibroblast (V-79-379A) proliferation and survival were tested in vitro. Barricaid, Fittydent and Reso-Pack periodontal dressings have only small inhibitory effects on cell proliferation (83.3 ± 9%, 71.6 ± 8.7% and 87.3 ± 4.5% of control after 48 h, respectively) in comparison with the great inhibitory effect of Myzotecttincture (2.9 ± 0.1%) and Peripac (33.7 ± 11.4%) (p < 0.001). Barricaid was the only dressing where 41% of cells survived after exposure, while the other four dressings killed all the cells in 6 days. In addition, the healing of artificially created gingival wounds covered by Barricaid and Reso-Pack was followed for 7 days in 12 Beagle dogs. Histological evaluation of gingival tissue demonstrated that wounds covered by Reso-Pack showed the best epithelisation and vascularity and the least inflammatory reaction in first 4 days. Later the observed parameters were similar with those of wounds covered by Barricaid or without pack. The present results indicate that Peripac periodontal dressing and Myzotect-tincture showed the highest cytotoxicity to fibroblasts in vitro. From the histological observations in Beagle dogs Reso-Pack has been found to be the most suitable dressing, followed by Barricaid.

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Section: Discussionmentioning

confidence: 99%

Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs

Petelin

Pavlica

Batista

et al. 2004

Acta Veterinaria Hungarica

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“…Adverse effects of eugenol in the oral cavity have been reported in association with its use in surgical and periodontal packs, 10 root canal sealers, 11,12 mouthrinses, 13 and in impression pastes. 14 Adverse reactions to eugenol amongst dental personnel are also well documented.…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, eugenol when placed in the mouth, can cause a more significant generalised allergic response. 12 One particularly sensitive patient is reported to have developed anaphylactic-like shock subsequent to a pulpotomy in which zinc-oxide and eugenol cement was used. 22 In the 1960s eugenol was a common constituent of dressings used after periodontal surgery.…”

Section: Discussionmentioning

confidence: 99%

Adverse reactions associated with the use of eugenol in dentistry

et al. 2002

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“…Entretanto, o eugenol é uma substância citotóxica, que pode desencadear a degeneração dos tecidos moles e morte de fi broblastos, além de dermatite de contato e reações alérgicas (Barkin et al, 1984;Sarrami et al, 2002). De acordo com Watts & Patterson (1987), a reação infl amatória persistente, necrose pulpar e ausência de reparo foram observadas após o uso desse cimento em exposições pulpares de ratos.…”

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Avaliação in vitro da atividade antibacteriana de um cimento odontológico à base de óleo-resina de Copaifera multijuga Hayne

Vasconcelos¹,

Veiga²,

Rocha³

et al. 2008

Rev. bras. farmacogn.

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RESUMO:Um dos materiais utilizados para a adequação do meio bucal no serviço público é o cimento produzido a partir de óxido de zinco e eugenol. Entretanto, o eugenol é uma substância citotóxica que pode desencadear alguns efeitos adversos. Por essa razão, procura-se substituir o eugenol por uma substância que apresente baixa toxicidade, mantendo ou mesmo melhorando as propriedades do cimento. O óleo-resina de copaíba é um produto natural, utilizado pelas populações amazônicas e reconhecido por suas propriedades medicinais. Baseando-se nas propriedades desse óleo-resina, na ação antimicrobiana comprovada do hidróxido de cálcio e na ação anti-séptica do óxido de zinco, propôs-se formular um cimento odontológico obtido da associação do ZnO, Ca(OH) 2 e óleo-resina de Copaifera multijuga Hayne e avaliar sua atividade antibacteriana através do teste de diluição em meio líquido frente às cepas padrão de Streptococcus mutans (ATCC 25175) e S. sanguinis (ATCC 15300). Nesse ensaio, utilizaram-se os seguintes grupos experimentais: o cimento contendo ZnO, Ca(OH) 2 e óleo-resina de copaíba (G1) e cada um dos constituintes isoladamente, ZnO (G2), Ca(OH) 2 (G3) e óleo-resina de copaíba (G4). Todos os grupos analisados demonstraram atividade antibacteriana, o G4 apresentou os melhores resultados e o G1 mostrou-se um cimento promissor a ser utilizado em odontologia.

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Acute allergic reaction to eugenol

Cited by 51 publications

References 2 publications

Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs

Effects of periodontal dressings on fibroblasts and gingival wound healing in dogs

Adverse reactions associated with the use of eugenol in dentistry

Avaliação in vitro da atividade antibacteriana de um cimento odontológico à base de óleo-resina de Copaifera multijuga Hayne

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