Active suspension control technologies have become increasingly significant in improving suspension performance for driving stability and comfort. An RBF-based fractional-order SMC fault-tolerant controller is developed in this research to guarantee ride comfort and handling stability when faced with the partial loss of actuator effectiveness due to failure. To obtain better control performance, fractional-order theory and the RBF algorithm are discussed to solve the jitter vibration problem in SMC, and the RBF is exploited to obtain a more appropriate switching gain. First, a half-nonlinear active suspension model and a fault car model are presented. Then, the design process of the RBF-based fractional-order SMC fault-tolerant controller is described. Next, a simulation is presented to demonstrate the effectiveness of the proposed strategy. According to the simulation, the proposed method can improve performance in the case of a healthy suspension, and the fault-tolerant controller can guarantee the capabilities when actuators go wrong.