ACTN3 R577X Polymorphism and Explosive Leg-Muscle Power in Elite Basketball Players

Garatachea, Nuria; Verde, Zoraida; Santos‐Lozano, Alejandro; Yvert, Thomas; Rodríguez-Romo, Gabriel; Sarasa, Francisco J.; Hernández-Sánchez, Sonsoles; Santiago, Catalina; Lucía, Alejandro

doi:10.1123/ijspp.2012-0331

Cited by 38 publications

(30 citation statements)

References 21 publications

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“…ACTN3 R alleli kızlarda 26, erkeklerde 12, X alleli ise kızlarda 8, erkeklerde 2 olarak bulunmuştur. İspanyol basketbolcularda yapılan bir çalışmada RR genotipi % 37, RX genotipi ise % 42 olarak bulunmuş, iki genotipin çalışma grubundaki oranı % 92 olarak bildirilmiştir (29). Bizim çalışma grubumuzda da RR genotipli oyuncular %67, RX genotipli oyuncular %25 olarak bulunmuş, toplam olarak RR ve RX genotiplerinin, yani en az bir R alleli içeren bireylerin oranı %92'dir.…”

Section: Introductionunclassified

Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism

Ulucan¹

2016

Clin Exp Health Sci

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The effect of genes on individual athletic performance is accepted; however, the extent of their effects remains elusive. To date, many studies on different genomic regions that are considered to have an effect on human athletic performance and sportsmen in different types of sports, such as football, basketball, judo, and wrestling, have been conducted. However, the number of these studies with Turkish players as subjects is not adequate. This literature review aimed to collate the results of alpha-actinin-3 (ACTN3) R577X polymorphisms of Turkish athletes after an extensive literature survey. After the survey, we could reach 518 players, including football, basketball, and wrestling players. Of these, 234 were RR (45%), 207 (40%) were RX, and the rest were XX. Power and sprinter R allele counts were 665 (64%), and the endurance allele count was 371 (36%). According to the obtained data, the number and percentage of RR+RX genotypes and R allele were higher than those of XX genotype and X allele. We consider that this first report will be an informative source of information for Turkish players in the terms of ACTN3 R577X polymorphism and Turkish sportsman and will be a valuable guide for new researches. Keywords: Sports, genetics, predisposition to sports, ACTN3, Turkey GİRİŞAtletik performans, sporcuların herhangi bir sportif aktivitelerinde gösterdikleri mental ve fiziksel performanslarının toplamı olarak kabul edilmektedir. Düzenli antrenman ile geliştirilebilen bir özellik olan atletik performansın hem oluşmasında, hem de gelişmesinde genetik faktörlerin katkısı yapılan çalışmalar ile ortaya konmuştur (1). Sadece bireysel sporlarda değil, aynı zamanda takım sporlarında da başarı için, genetik yapıya uygun antrenman ve beslenme programlarının oluşturulması şüphesiz ki büyük önem taşımaktadır. Bu yüzden spor genetiği alanında yapılan çalışmalar son yıllarda sporun büyüyen ekonomisiyle beraber büyük önem kazanmıştır.Spor genetiği alanında yapılan çalışmaların büyük bir bölümü alfa-aktinin-3 geni (ACTN3) üzerine yoğunlaşmıştır. Aktinin protein ailesinin memelilerde 4 farklı formu bulunmaktadır. ACTN1 ve ACTN4 alternatif splays mekanizması ile sentez edilir. Merkezi sinir sisteminde ve düz kaslarda Ca ++ duyarsız varyantları ile birçok dokuda eksprese edilen Ca ++ duyarlı formları bulunmaktadır (2). ACTN1, birçok hücrede aktin filamentlerinin birbirine bağlanmasını sağlayarak bu yapıların hücre-hücre ve hücre-matriks bağlantı yapılarına daha sıkı bağlan-malarını sağlamaktadır, bu nedenle sitokinez, hücre adezyonu ve hücre hareketleri gibi hücresel işlevlerde rol oynamaktadır (3). ACTN2 kalp ve çizgili kas gibi kas tiplerinde ve beyin dokusunda ekpresyona uğrar, kas dokusunda sarkomerlerde anti-paralel olarak uzanan aktin filamentlerinin Z-çizgisine bağlanmasını sağlar (4). Kimi araştırmacılar da dominant olarak kalıtılan bazı miyopatileri bu gen üzerindeki missens mutasyonuna bağlamışlardır (4). ACTN4 ise bu ailenin kas dışı izoformu olarak bilinir, ACTN1 ile yüksek derecede yapısal homoloji göstermelerine rağmen...

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Section: Introductionunclassified

Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism

Ulucan¹

2016

Clin Exp Health Sci

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“…Exploration of the association between the ACTN3 genotype and the actual anaerobic performance phenotype is important to help trained athletes, especially those in power-oriented sports, to design more suitable individualized training programs. Despite this importance, the WAnT was not employed in the previous studies (7,15) concerning the specific role of the ACTN3 genotype in trained athletes.…”

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The ACTN3 R577X Polymorphism Is Associated With Muscle Power in Male Japanese Athletes

Kikuchi

Nakazato

Min

et al. 2014

Journal of Strength and Conditioning Research

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In this study, we investigated whether the ACTN3 R577X polymorphism is associated with muscular power in Japanese collegiate athletes by analyzing the mean and peak power results of a 30-second Wingate anaerobic test (WAnT) with respect to the ACTN3 R577X genotype in 253 Japanese athletes (144 men and 109 women). Each athlete performed a 30-second WAnT with a resistance equal to 7.5% of his or her body weight. Genotyping for the ACTN3 R577X (rs1815739) polymorphism was performed using the TaqMan approach. The ACTN3 R577X genotypes exhibited a Hardy-Weinberg equilibrium distribution in our population. The relative and absolute mean power results of the 30-second WAnT did not differ significantly among the genotypes. However, the relative peak power result of the WAnT was significantly higher in the R-allele-dominant model groups than in the XX group in male but not female athletes. These results suggest that the ACTN3 R allele is associated with the relative peak power during the WAnT in male Japanese collegiate athletes.

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“…When different fields are in question, no relationship was detected between ACTN3 genotype distribution and jump tests in elite male volleyball players and elite male and female basketball players [24, 29]. In Polish athletes from different disciplines (volleyball, swimming, canoe, ice hockey), RR-genotyped athletes jumped significantly higher than XX- genotyped athletes [30].…”

Section: Discussionmentioning

confidence: 99%

The relationship between ACTN3 R577X gene polymorphism and physical performance in amateur soccer players and sedentary individuals

Koku¹,

Karamizrak²,

Çiftçi³

et al. 2019

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The aim of this study was to determine the distribution of ACTN3 R577X gene polymorphism in soccer players and sedentary individuals, and to investigate the relationship of this distribution with performance tests. A total of 100 soccer players and 101 sedentary individuals were enrolled in the study. Standing long jump and countermovement jump (with arm swing, without arm swing and repeated) scores were recorded, using a jump meter. Maximum VO2 levels were measured using a treadmill-connected cardiopulmonary exercise device, Masterscreen CPX. ACTN3 R577X polymorphism was evaluated by real-time PCR. ACTN3 R577X genotype distribution was found to be similar in soccer players and controls (p>0.05). The only statistically significant finding was a shorter countermovement jump with arm swing scores in the RR-genotyped soccer players, compared with their RX genotyped counterparts (p<0.05). In the soccer player group, RX-genotyped subjects were observed to have lower respiratory threshold values compared with RR-genotyped subjects (p<0.05). No significant correlation was detected between this distribution and performance test results. ACTN3 R577X genotype distribution was found to have no effect on sprint and endurance characteristics in amateur soccer players. The ACTN3 R577X polymorphism may not be a specific enough genetic marker to determine athletic performance in soccer.

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ACTN3 R577X Polymorphism and Explosive Leg-Muscle Power in Elite Basketball Players

Abstract: Although the ACTN3 R577X is associated with explosive muscle performance and this phenotype is important in the sport of basketball (ie, during jumps), the authors found no association with leg explosive power in elite basket players or with the status of being this type of athlete.

Cited by 38 publications

References 21 publications

Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism

Literature Review of Turkish Sportsmen in Terms of ACTN3 R577X Polymorphism

The ACTN3 R577X Polymorphism Is Associated With Muscle Power in Male Japanese Athletes

The relationship between ACTN3 R577X gene polymorphism and physical performance in amateur soccer players and sedentary individuals

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