The relationship between ACTN3 R577X gene polymorphism and physical performance in amateur soccer players and sedentary individuals

Koku, Fatma Ebru; Karamizrak, S. Oğuz; Çiftçi, Aynur S.; Taslidere, Hasan; Durmaz, Burak; Çoğulu, Özgür

doi:10.5114/biolsport.2018.78900

Cited by 14 publications

(8 citation statements)

References 31 publications

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“…Although other research has studied the prevalence of genetic polymorphisms related to athletic performance among soccer players (e.g., Coelho et al, 2016b;Dionísio et al, 2017b;Honarpour, Mohseni, Ghavidel Hajiagha, Irani, & Najmabadi, 2017;Juffer et al, 2009;Koku et al, 2019;Monnerat, Maior, Tannure, Back, & Santos, 2018), the current study is the first to explore the prevalence of the ACSL A/G single nucleotide polymorphism among professional national-team level soccer players. In contrast to our hypothesis, and despite the importance of aerobic capacity for soccer performance, the frequency of the ACSL AA genotype carriers, which is related to reduced endurance trainability assessed by the VO 2 max response to training, was significantly higher among the soccer players (35%) compared to longdistance runners (15%), and even to sprinters and jumpers (15%) and controls (12%).…”

Section: Discussionmentioning

confidence: 97%

High Prevalence of the ACSL (rs6552828) AA Genotype among Elite Soccer Players

Meckel

Eliakim

Nemet

et al. 2022

BJSHS

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Background: The ACSL A/G single nucleotide polymorphism is associated with endurance trainability. It was previously demonstrated that AA carriers had a reduced maximal oxygen consumption (VO2 max) in response to training compared to GG carriers, and that this polymorphism explained 6.1% of the variance in the VO2 max response to training. The aim of the present study was to determine the prevalence of the ACSL A/G polymorphism among soccer players. Methods: One hundred and sixty-seven male athletes (60 soccer players, 48 sprinters and jumpers, 59 long distance runners) and 60 non-athletic controls participated in the study. Genomic DNA was extracted from buccal epithelial cells using standard protocol for ACSL genotyping. Results: The prevalence of the ACSL AA genotype was significantly higher among soccer players (35%) compared to controls (12%), sprinters and jumpers (15%) and long-distance runners (15%). The findings suggest that despite the importance of aerobic capacity for soccer performance, the prevalence of ACSL AA carriers – a genotype that was related to reduced endurance trainability – is significantly higher among soccer players compared to endurance and power athletes and controls. This genetically unfavorable predisposition should be considered when selecting the team squad and when planning fitness training modalities throughout the competitive season. Keywords: sprinters, long-distance runners, soccer players, ACSL genetic polymorphism.

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Section: Discussionmentioning

confidence: 97%

High Prevalence of the ACSL (rs6552828) AA Genotype among Elite Soccer Players

Meckel

Eliakim

Nemet

et al. 2022

BJSHS

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“…Respecto al gen ACTN3, de la misma forma que en este estudio, Barbosa et al, (2018) reportaron la misma incidencia del genotipo RX, en un grupo de futbolistas brasileños. Al igual que en otros estudios, se ha demostrado una similitud con los resultados encontrados en esta investigación (Dionísio et al, 2017;Eynon et al, 2014;Koku et al, 2019;Massidda et al, 2012). No obstante, existe literatura que indica que el polimorfismo RR es el de mayor dominancia en atletas de deporte colectivo (Egorova et al, 2014;Galeandro et al, 2017;Santiago et al, 2008;Ulucan et al, 2015).…”

Section: Discussionunclassified

El Análisis de los polimorfismos ECA y ACTN3 con la agilidad en seleccionados nacionales de deportes de conjunto de Costa Rica. Estudio piloto

Carvajal-Espinoza

Trejos-Montoya²,

Herrera-González³

et al. 2023

MHSalud

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Objetivo: Analizar las diferencias de los polimorfismos de los genes ECA y ACTN3 en el rendimiento de una prueba de agilidad en jugadores élite de deportes colectivos pertenecientes a selecciones nacionales de Costa Rica. Metodología: Se contó con una muestra de 33 jugadores hombres, de deportes colectivos (fútbol sala, rugby, voleibol y balonmano). Para la evaluación de la agilidad se utilizó el test de Illinois. Se realizaron dos visitas, en la primera se obtuvo muestras de células por medio de un enjuague y en la segunda se aplicó la prueba de agilidad. Se utilizó la prueba de Chi-cuadrado (X2) para conocer las diferencias entre las frecuencias de los polimorfismos de los genes ECA y ACTN3 y el tipo de deporte. Resultados: La mayor distribución de los polimorfismos del gen ECA, de jugadores de selecciones nacionales de deportes de conjunto, se encuentra en el ID (X2= 6.87, p= .334) y en ACTN3 el RX (X2= 6.33, p= .388). Además, tampoco se encontraron diferencias significativas entre el tiempo efectuado en el test de Illinois y los polimorfismos del gen ECA (F= 2.150, p= .134), de igual forma para los polimorfismos del gen ACTN3 (F= .950, p= .339). Conclusiones: Los polimorfismos de los genes ECA y ACTN3 no se relacionaron estadísticamente con el tipo de deporte colectivo. La agilidad no se ve asociada por un tipo de polimorfismo, lo que indica que, de forma independiente al gen, esta cualidad física se puede entrenar y generar buenos resultados en la población en general.

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“…Although some research have established that the genetic background of ACTN3 R577X and/or ACE I/D polymorphisms play an important role in sporting potential, which might explain why some individuals may be better adapted to specific physical training or performance (Chiu et al, 2019;Coelho et al, 2018;Del Coso et al, 2019;Kikuchi et al, 2015;Li et al, 2017;Massidda et al, 2019;R. Yang et al, 2017;Znazen et al, 2015), readers should note that other studies have reported no association between the ACTN3 R577X and/or ACE I/D polymorphism and athletic performance (Falahati & Arazi, 2019;Koku et al, 2019;Maciejewska-Skrendo, Cięszczyk, Chycki, Sawczuk, & Smółka, 2019;Massidda et al, 2015;Miyamoto, Miyamoto-Mikami, Hirata, Kimura, & Fuku, 2018;Moreno-Pérez, Machar, Sanz-Rivas, & Del Coso, 2020;Papadimitriou et al, 2018). For example, the findings of Orysiak et al (Orysiak et al, 2018) do not support an influential role of ACE I/D and ACTN3 R577X genotypes (alone or in combination) on power/strength performance in elite Polish athletes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of ACTN3 R577X and ACE I/D polymorphisms in young Colombian athletes: An exploratory research

Ortiz¹,

Ayala²,

Petro³

et al. 2020

jhse

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There are genetic sequences that might be associated with improved athletic performance, such as the α-actinin-3 (ACTN3) R577X polymorphism and the angiotensin-converting enzyme (ACE) insertion/deletion (I/D), which are related to phenotypes of increased muscle strength and endurance, respectively. This STREGA-based crosssectional study compared the genotype and allele frequencies of the ACTN3 R577X and ACE I/D polymorphisms between Colombian athletes (n = 37) and non-athletic controls (n = 37). Genotyping was performed using polymerase chain reaction (PCR) and subsequent enzymatic restriction (RFLP). The distribution of the ACTN3 R577X genotype of control and athletic groups met Hardy-Weinberg Equilibrium (HWE) (all p > .05); however, in the strength-trained athletes, the distribution of the ACE I/D genotype was not found in HWE. In athletic population, genotype distribution and allele frequencies of the ACTN3 R577X (n = 37) was RR: 35.1% (n = 13), RX: 54.1% (n = 20), XX: 10.8% (n = 4), and R: 0.6216 and X: 0.3784, respectively. For ACE I/D (n = 74) it was found a genotype distribution of DD: 35.1% (n = 13), ID: 24.3% (n = 9), II: 40.5% (n = 15), and allelic frequencies of D: 62.16% and I: 37.84%. Statistical analysis showed an association between the ACE genotypes with strength, endurance and control groups (X 2 = 15.3, gl = 4, p = .004); however, the ACTN3 R577X polymorphism did not have a significant association (X 2 = 3.99, gl = 4, p = .408). Although studies with a more homogeneous and larger sample size are required, the results of this exploratory study contribute to the genotypic characterization of Colombian athletes with the objective of improving the methodologies and its applications to sports medicine.

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The relationship between ACTN3 R577X gene polymorphism and physical performance in amateur soccer players and sedentary individuals

Cited by 14 publications

References 31 publications

High Prevalence of the ACSL (rs6552828) AA Genotype among Elite Soccer Players

High Prevalence of the ACSL (rs6552828) AA Genotype among Elite Soccer Players

El Análisis de los polimorfismos ECA y ACTN3 con la agilidad en seleccionados nacionales de deportes de conjunto de Costa Rica. Estudio piloto

Evaluation of ACTN3 R577X and ACE I/D polymorphisms in young Colombian athletes: An exploratory research

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