Activity on the Gastrointestinal Tract

Vogel, H. Gerhard

doi:10.1007/978-3-540-70995-4_11

Cited by 4 publications

(5 citation statements)

References 999 publications

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“…Indomethacin is known to cause gastrointestinal ulcers via several mechanisms including inhibition of PGE2 synthesis, generation of free radicals, decreasing in nitric oxide level, and increasing gastric acid secretion (Vogel, 1997). .…”

Section: Resultsmentioning

confidence: 99%

Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

Gupta

Vishwakarma

Giri

et al. 2019

J. Pharm. Technol. Res. Manag.

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Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.

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Section: Resultsmentioning

confidence: 99%

Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

Gupta

Vishwakarma

Giri

et al. 2019

J. Pharm. Technol. Res. Manag.

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“…The ulcer index was evaluated using the method described earlier. [ 13 ] Various parameters such as area of gastric lesion, NP-SH concentration, gastric wall mucus concentration, total acidity and volume of gastric content; and histopathological parameters like hemorrhage, edema, erosion, ulceration were studied and compared between all the four groups of rats. Procedures for determination of all other parameters listed in Tables 1 and 2 were performed as per the reported procedures.…”

Section: Methodsmentioning

confidence: 99%

Antiulcer activity of aqueous extract of fruits ofMomordica cymbalariaHook f. inWistarrats

Dhasan

Jegadeesan

Kavimani³

2010

Phcog Res

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Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5%-10% of people during their life. The ulcer is an open sore that develops on the inside lining of the stomach (a gastric ulcer) or the small intestine (a duodenal ulcer). Both types of ulcers are also referred to as peptic ulcer disease. The present study was carried out to investigate antiulcer activity of aqueous extract of fruits of Momordica cymbalaria Hook f. Initially the aqueous extract of M. cymbalaria was subjected to acute oral toxicity study according to the Organisation for Economic Co-operation and Development (OECD) guidelines, based on which, 500 mg/kg dose of aqueous extract was selected for the study. The animals were pretreated before inducing ulcer. For inducing ulcer in the rats, 80% ethanol was used. Various parameters such as area of gastric lesion, nonprotein sulfhydryls (NP-SH) concentration, gastric wall mucus concentration, total acidity and volume of gastric content; and histopathological parameters like hemorrhage, edema, erosion, ulceration were studied in the control group and pretreated groups with aqueous extract of fruits of Momordica cymbalaria (500 mg/kg) and standard drug lanzoprazole (30 mg/kg). Pretreatment with aqueous extract of M. cymbalaria fruits showed significant (P < 0.05) decrease in the total acidity and ulcer index. Improvements in all histopathological parameters were noticed in the M. cymbalaria-treated group. It also showed significant decrease in gastric lesion and NP-SH and gastric wall mucus concentrations in the M. cymbalaria-treated group. Overall the aqueous extract of M. cymbalaria fruits was shown to possess significant (P < 0.05) antiulcer property in rats. The polyphenols like quercetin reported from the plant may attribute to the antiulcer property of the extract.

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“…The pellets were incubated at 37°C for 24 h and dried at 60°C for constant weight. Increment in the dry weight of the pellets was taken as measure of granuloma formation [23].…”

Section: Cotton Pellet-induced Granulomamentioning

confidence: 99%

Improved Gastrodin Production of Biotransformation Conditions by Cultured Cells Armillaria luteo-virens Sacc and the Anti-inflammatory Activity In Vivo

Niu¹

2016

Med chem

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Gastrodin (GAS), the main bioactive component of G. elata Blume, has important pharmaceutical and functional activities. The aim of this study is to produce GAS from p-2-hydroxybenzyl alcohol (HBA) through biotransformation. The conversion of exogenous HBA into GAS compound was conducted using cell suspension cultures of Armillaria luteovirens Sacc. The bioconversion conditions were fully optimized with response surface methodology (RSM), turning out that the optimal transformation conditions composed of 3 mg/mL HBA, 6.5 g/30 mL inoculums level, 1.5% Tween 80, pH 4.5, and transformation temperature at 23°C. Under the optimized conditions, the conversion productivity of GAS reached the highest value (5.65 ± 0.45 mg/L). Verified experiments further validated that the optimized conditions were suitable for predicting the actual process of HBA transformation in the resting-cell system. The bioconversion kinetics model was as well simulated with Michaelis-Menten equation, which showing the suitability. The present study proposed the biotransformation pathway of HBA into GAS by resting cells transformation, indicating that the biotransformation process involved glucosylation reaction. Furthermore, Imprinting Control Region (ICR) mice in vivo demonstrated that the identified gastrodin possessed a significant anti-inflammatory activity. The fundamental data in the present work provides an efficient way to produce GAS through the whole-cells biocatalysis.

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Activity on the Gastrointestinal Tract

Cited by 4 publications

References 999 publications

Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

Gastroprotective Effect of Symplocos Racemosa Whole Plant Methanolic Extract Against Experimentally Induced Gastric Ulcer in Rat

Antiulcer activity of aqueous extract of fruits ofMomordica cymbalariaHook f. inWistarrats

Improved Gastrodin Production of Biotransformation Conditions by Cultured Cells Armillaria luteo-virens Sacc and the Anti-inflammatory Activity In Vivo

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