A new triglycoside of luteolin, verbacoside, isolated from the whole plant of Verbascum thapsus has been characterized as luteolin 5-O-a-~-rhamnopyranosyl( 1-3)-[p-~-glucuronopyranosyl( 1~6)]-~-D-glucopyranoside [l] through spectral and chemical studies.
Peptic ulcer is a condition which results from an imbalance between offensive and defensive factors of gastrointestinal system. The investigation was designed to evaluate the antiulcer activity of Symplocos racemosa whole plant methanol extract (MESR) in rat model of indomethacininduced gastric ulceration. The total acidity, gastric volume, pH and free acidity were measured to determine the anti-ulcer activity of MESR. Pretreatment with MESR (125-500 mg/kg) markedly reduced the indomethacin-induced increase in gastric ulcer index and score. These results revealed that antisecretory effects MESR were responsible for antiulcer activity of MESR.
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