Activity evaluation on Ribes species, traditionally used to speed up healing of wounds: With special focus on Ribes nigrum

Kendir, Gülsen; Süntar, İpek; Çeribaşı, Ali Osman; Köroğlu, Ayşegül

doi:10.1016/j.jep.2019.03.038

Cited by 15 publications

(10 citation statements)

References 36 publications

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“…R. nigrum and R. multiflorum extracts showed the most promising results, the preparations significantly increased wound breaking strength and significantly reduced the wound areas on the 15th day. Since R. nigrum was found to be the most active species, the authors further investigated the wound healing potential of the fractions obtained by the methanol extract of R. nigrum leaves, discovering the ethyl acetate as the most active [ 62 ].…”

Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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During the last 30 years, berries have gained great attention as functional food against several risk factors in chronic diseases. The number of related publications on Pubmed rose from 1000 items in 1990 to more than 11,000 in 2019. Despite the fact that a common and clear definition of “berries” is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. Skin insults, like wounds, UV rays, and excessive inflammatory responses, may lead to chronic dermatological disorders, conditions often characterized by long-term treatments. The application of berries for skin protection is sustained by long traditional use, but many observations still require a clear pharmacological validation. This review summarizes the scientific evidence, published on EMBASE, MEDLINE, and Scholar, to identify extraction methods, way of administration, dose, and mechanism of action of berries for potential dermatological treatments. Promising in vitro and in vivo evidence of Punica granatum L. and Vitis vinifera L. supports wound healing and photoprotection, while Schisandra chinensis (Turcz.) Baill. and Vaccinium spp. showed clear immunomodulatory effects. Oral or topical administrations of these berries justify the evaluation of new translational studies to validate their efficacy in humans.

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Section: Resultsmentioning

confidence: 99%

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

et al. 2020

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“…The leaves of Ribes genus have received considerable attention for their health‐promoting properties. The leaf extracts obtained from Ribes have been reported to possess antioxidant [1–3], anti‐inflammatory [2], antimicrobial [4], and wound‐healing activities [5]. These biological activities are closely related to the phenolic compounds, particularly flavonoids and phenolic acids [1, 6].…”

Section: Introductionmentioning

confidence: 99%

Rapid qualitative profiling and quantitative analysis of phenolics in Ribes meyeri leaves and their antioxidant and antidiabetic activities by HPLC‐QTOF‐MS/MS and UHPLC‐MS/MS

Zhao

Wang

et al. 2021

J of Separation Science

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Ribes meyeri leaves are used as traditional Kazakh medicine in China. However, no study on the characterization of the phenolic compounds in R. meyeri leaves has been reported, resulting in the lack of quality control measures and poor standardization. This study was conducted to identify the phenolic compounds in R. meyeri leaves and evaluate their antioxidant and antidiabetic activities. A total of 77 phenolics were tentatively identified by liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry. Ultra‐high performance liquid chromatography coupled with triple quadrupole mass spectrometry was applied to simultaneously quantify 12 phenolics in R. meyeri leaves. Rutin, epigallocatechin, isoquercitrin, epicatechin, protocatechuic acid, and kaempferol‐3‐O‐rutinoside were abundant in the R. meyeri leaves. The methanol extract and four different extracts enhanced the glucose uptake in 3T3‐L1 adipocytes. The ethyl acetate extracts showed a total phenolic content of 966.89 ± 3.59 mg gallic acid equivalents/g, a total flavonoid content of 263.58 ± 17.09 mg catechin equivalents/g, and good protein‐tyrosine phosphatase‐1B inhibitory activities (IC50: 0.60 ± 0.03 μg/mL). To our knowledge, this work is the first to identify and quantify the major phenolics in R. meyeri leaves.

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“…The traditional use of blackcurrant leaf extracts rich in polyphenols has been investigated and validated in various models of inflammation [6,7] and oxidative stress [8]; however, the possible impact on skin disorders is still largely unknown. Recently, our research group extensively reviewed the preclinical data on the effect of Ribes spp.…”

Section: Introductionmentioning

confidence: 99%

Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

et al. 2021

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Ribes nigrum L. (blackcurrant) leaf extracts, due to high levels of flavonols and anthocyanins, have been shown to exhibit beneficial effects in inflammatory diseases. However, whereas their traditional use has been investigated and validated in several models of inflammation and oxidative stress, the possible impact on skin disorders is still largely unknown. The purpose of this work was to elucidate the effects of R. nigrum leaf extract (RNLE) on keratinocyte-derived inflammatory mediators, elicited by a Th1 or Th2 cytokine milieu. HaCaT cells were challenged with TNF-α, either alone or in combination with the costimulatory cytokines IFN-γ or IL-4, and the release of proinflammatory cytokines and mediators (IL-8, IL-6, s-ICAM-1, and TSLP) was evaluated. The results showed that RNLE preferentially interferes with IFN-γ signaling, demonstrating only negligible activity on TNF-α or IL-4. This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-α/IL-4-induced TSLP release in a cAMP-independent manner. These results suggest that RNLE could have an antiallergic effect mediated in keratinocytes via mechanisms beyond histamine involvement. In conclusion, the discovery of RNLE preferential activity against IFN-γ-mediated inflammation suggests potential selectivity against Th1 type response and the possible use in Th1 inflammatory diseases.

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Activity evaluation on Ribes species, traditionally used to speed up healing of wounds: With special focus on Ribes nigrum

Cited by 15 publications

References 36 publications

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders

Rapid qualitative profiling and quantitative analysis of phenolics in Ribes meyeri leaves and their antioxidant and antidiabetic activities by HPLC‐QTOF‐MS/MS and UHPLC‐MS/MS

Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

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