Active Microelectronic Neurosensor Arrays for Implantable Brain Communication Interfaces

Abstract

We have built a wireless implantable microelectronic device for transmitting cortical signals transcutaneously. The device is aimed at interfacing a microelectrode array cortical to an external computer for neural control applications. Our implantable microsystem enables presently 16-channel broadband neural recording in a non-human primate brain by converting these signals to a digital stream of infrared light pulses for transmission through the skin. The implantable unit employs a flexible polymer substrate onto which we have integrated ultra-low power amplification with analog multiplexing, an analog-to-digital converter, a low power digital controller chip, and infrared telemetry. The scalable 16-channel microsystem can employ any of several modalities of power supply, including via radio frequency by induction, or infrared light via a photovoltaic converter. As of today, the implant has been tested as a sub-chronic unit in non-human primates (~ 1 month), yielding robust spike and broadband neural data on all available channels.

A bio-friendly and economical technique for chronic implantation of multiple microelectrode arrays

“…); price calculations are based on: NP raw cost ∼100$, Headpost price ∼600$, single bone screw price ∼50$, bone cement price ∼500$; Cereport price ∼4500$, ICS-96 price ∼2250$. for trans-cutaneous protrusions, realization of such implants is in its nascent stage with their capacity limited to a few channels (Song et al, 2009). In the meantime the described nesting platform allows possibly the most bio-friendly and economical means of conducting chronic neurophysiological experiments with multiple microeletrode arrays.…”

A Brief Review of Brain Signal Monitoring Technologies for BCI Applications: Challenges and Prospects

“…Poly 3,4 -ethylenedioxythiohene (PEDOT) was studied as alternative for chronic use. Preferential growth of neuron and high quality recording was observed on the coated area of standard acute Michigan probes coated with PEDOT/DCDPGYIGSR (DCDPGYIGSR is a bioactive peptide) [64,65]. Dexamethasone is a corticosteroid and a potent anti-inflammatory agent, incorporated on Michigan probes showed reduced gliosis and invasive electrode encapsulation [15].…”

An Innovative Design: MOS Based Full-Wave Centre-Tapped Rectifier

“…The measured results signify that the maximum dc voltage is obtained at 20 MHz. The circuits were formerly optimized to produce the maximum dc voltage at the output when the peak RF signal is 20 MHz and the input voltage is 2 V [39]. In these conditions, the circuit produces an output dc voltage (V out ) of approximately 1.85 V, with a load resistance of R L = 10 kX.…”