Activation of the extracellular signal-regulated kinase signal pathway by light emitting diode irradiation

Komine, Nobuhiko; Ikeda, Kazuo; Tada, Kazuhiro; Hashimoto, Noriyuki; Sugimoto, Naotoshi; Tomita, Katsuro

doi:10.1007/s10103-009-0743-7

Cited by 25 publications

(20 citation statements)

References 29 publications

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“…However, not all studies reported the dose applied. 64,66,67,68 Biological effects observed were reduction of inflammatory cells, increased fibroblast proliferation, collagen synthesis, stimulation of angiogenesis and granulation tissue formation, these being similar to the ones observed in studies with LASER.…”

Section: Resultssupporting

confidence: 79%

Effects of low-power light therapy on wound healing: LASER x LED

Chaves

Araújo

Piancastelli

et al. 2014

An. Bras. Dermatol.

217

123

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Several studies demonstrate the benefits of low-power light therapy on wound healing. However, the use of LED as a therapeutic resource remains controversial. There are questions regarding the equality or not of biological effects promoted by LED and LASER. One objective of this review was to determine the biological effects that support the use of LED on wound healing. Another objective was to identify LED´s parameters for the treatment of wounds. The biological effects and parameters of LED will be compared to those of LASER. Literature was obtained from online databases such as Medline, PubMed, Science Direct and Scielo. The search was restricted to studies published in English and Portuguese from 1992 to 2012. Sixty-eight studies in vitro and in animals were analyzed. LED and LASER promote similar biological effects, such as decrease of inflammatory cells, increased fibroblast proliferation, stimulation of angiogenesis, granulation tissue formation and increased synthesis of collagen. The irradiation parameters are also similar between LED and LASER. The biological effects are dependent on irradiation parameters, mainly wavelength and dose. This review elucidates the importance of defining parameters for the use of light devices.

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Section: Resultssupporting

confidence: 79%

Effects of low-power light therapy on wound healing: LASER x LED

Chaves

Araújo

Piancastelli

et al. 2014

An. Bras. Dermatol.

217

123

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“…Cultured NIH3T3 fibroblasts from normal mice in 10% FCS were irradiated by RLED at 627 nm and 25 mW/cm 2 twice, first at subculture and 24 h later. At day 2, Komine et al observed the RLED promoted cell growth of NIH3T3 fibroblasts and increased the expression of platelet-derived growth factor (PDGF)-C, but did not affect the expression of PDGF-A, PDGF-B, and TGF-beta [79]. As Komine et al have pointed out [79], one possible mechanism of fibroblast proliferation induced by RLED involves an increase of PDGF-C expression and activation of the ERK pathway through phosphorylation of the PDGF receptor.…”

Section: Indirect Photobiomodulationmentioning

confidence: 99%

Photobiomodulation on Stress

Liu

Enxiu

et al. 2012

International Journal of Photoenergy

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Photobiomodulation (PBM) is a nondamaged modulation of laser irradiation or monochromatic light (LI) on a biosystem function. It depends on whether the function is in its function-specific homeostasis (FSH). An FSH is a negative-feedback response of a biosystem to maintain the function-specific conditions inside the biosystem so that the function is perfectly performed. A function in its FSH is called a normal function. A function far from its FSH is called a dysfunctional function. The process of a function from dysfunctional to normal is called a functional normalization. For a normal function in its FSH, there are FSH-essential subfunctions (FESs), FSH-nonessential subfunctions (FNSs), and an FES/FNS-specific homeostasis (FESH/FNSH). A FSH can resist internal/external disturbances under the threshold, but can be disrupted by an FSH-specific stress (FSS). A normal/dysfunctional FSS is called a successful/chronic stress. An FESH/FNSH-specific stress was called an extraordinary/ordinary stress. A low level LI (LLL) cannot directly affect a normal function, but can modulate a chronic stress. A normal function may have a chronic ordinary stress, and an LLL may modulate the chronic ordinary stress so that it promotes the normalization of the dysfunctional FNS and then upgrades the normal function. A high level LI can modulate a normal function and may be a successful stress.

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“…The cells were irradiated with RLED 627 at 25 mW/cm 2 for 160 s twice,¯rst at subculture and 24 h later. Komine et al 38 found RLED 627 promoted the proliferation in its PlSH 24 h after the second irradiation. In the irradiated group, they further found that the expression of platelet-derived growth factor (PDGF)-C had signi¯cantly increased, but the expression of PDGF-A, PDGF-B, basic¯bro-blast growth factor (bFGF), TGF-beta, PDGFalpha receptor, and TGF-beta receptor did not change.…”

Section: Platelet-derived Growth Factor-cmentioning

confidence: 97%

Photobiomodulation-Mediated Pathway Diagnostics

Liu

Zhu

Yang

2013

J. Innov. Opt. Health Sci.

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Cellular pathways are ordinarily diagnosed with pathway inhibitors, related gene regulation, or°u orescent protein markers. They are also suggested to be diagnosed with pathway activation modulation of photobiomodulation (PBM) in this paper. A PBM on a biosystem function depends on whether the biosystem is in its function-speci¯c homeostasis (FSH). An FSH, a negative feedback response for the function to be performed perfectly, is maintained by its FSH-essential subfunctions and its FSH-non-essential subfunctions (FNSs). A function in its FSH or far from its FSH is called a normal or dysfunctional function. A direct PBM may self-adaptatively modulate a dysfunctional function until it is normal so that it can be used to discover the optimum pathways for an FSH to be established. An indirect PBM may self-adaptatively modulate a dysfunctional FNS of a normal function until the FNS is normal, and the normal function is then upgraded so that it can be used to discover the redundant pathways for a normal function to be upgraded.

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Activation of the extracellular signal-regulated kinase signal pathway by light emitting diode irradiation

Cited by 25 publications

References 29 publications

Effects of low-power light therapy on wound healing: LASER x LED

Effects of low-power light therapy on wound healing: LASER x LED

Photobiomodulation on Stress

Photobiomodulation-Mediated Pathway Diagnostics

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