Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice

Tang, Shuming; Ren, Yi; Xu, Lijie; Cao, Jingran; Hong, Hao; Ji, Hui; Hu, Qinghua

doi:10.1016/j.yhbeh.2018.08.002

Cited by 12 publications

(9 citation statements)

References 55 publications

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“…Most phytoestrogens are full ERβ agonists and weak ligands of the ERα ( Gencel et al, 2012 ; Martinkovich et al, 2014 ). Estrogenic compounds support cognitive abilities by a mechanism involving the ERα ( Tang S.-S. et al, 2018 ; Mitchnick et al, 2019 ). This receptor, acting as a transcription factor, controls gene expression in brain regions playing a vital role in learning and memory, such as the hippocampus ( Spencer-Segal et al, 2012 ; Frick et al, 2018 ; Tang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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In mammals, sexual hormones such as estrogens play an essential role in maintaining brain homeostasis and function. Estrogen deficit in the brain induces many undesirable symptoms such as learning and memory impairment, sleep and mood disorders, hot flushes, and fatigue. These symptoms are frequent in women who reached menopausal age or have had ovariectomy and in men and women subjected to anti-estrogen therapy. Hormone replacement therapy alleviates menopause symptoms; however, it can increase cardiovascular and cancer diseases. In the search for therapeutic alternatives, medicinal plants and specific synthetic and natural molecules with estrogenic effects have attracted widespread attention between the public and the scientific community. Various plants have been used for centuries to alleviate menstrual and menopause symptoms, such as Cranberry, Ginger, Hops, Milk Thistle, Red clover, Salvia officinalis, Soy, Black cohosh, Turnera diffusa, Ushuva, and Vitex. This review aims to highlight current evidence about estrogenic medicinal plants and their pharmacological effects on cognitive deficits induced by estrogen deficiency during menopause and aging.

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Section: Introductionmentioning

confidence: 99%

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

et al. 2021

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“…Globally, the epidemic of diabetes presents a great challenge in current healthcare system due to the rapidly increasing number of patients with diabetes scheduled for surgery. 5 In the present study, [35][36][37] Accordingly, our findings suggest that the modulation of mTOR-mediated autophagy signaling could be a novel and promising strategy for the treatment of PND in diabetic patients.…”

Section: Discussionmentioning

confidence: 74%

mTOR‐mediated autophagy in the hippocampus is involved in perioperative neurocognitive disorders in diabetic rats

et al. 2021

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“…Additionally, a strong positive correlation between ERα protein expression levels and LTM was observed in the PFC of TBT mice ( Supplementary Figure 2C ). E2 is an ovarian steroid hormone that acts through the activation of ERs, playing a key role in normal brain function, neuroprotection, memory, and cognitive processes (Garcia-Segura et al, 2001 ; Marin et al, 2003 ; Arevalo et al, 2015 ; Tang et al, 2018 ). Fernandez et al ( 2008 ) demonstrated that E2 (0.2 mg/kg) administration increases protein expression of phosphorylated ERK in the dorsal hippocampus from ovariectomized rats, increasing memory retention after an object recognition task in a training session.…”

Section: Discussionmentioning

confidence: 99%

Tributyltin Exposure Is Associated With Recognition Memory Impairments, Alterations in Estrogen Receptor α Protein Levels, and Oxidative Stress in the Brain of Female Mice

et al. 2021

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Tributyltin (TBT) is a persistent organometallic pollutant widely used in several agricultural and industrial processes. TBT exposure is associated with various metabolic, reproductive, immune, and cardiovascular abnormalities. However, few studies have evaluated the effects of TBT on behavior. In the present study, we aimed to investigate whether TBT exposure results in oxidative, neuroendocrine, and behavioral alterations. TBT was administered to adult female mice (250, 500, or 750 ng/kg/day or veh for 14 days), and their recognition memory was assessed. We have also evaluated estrogen receptor (ER)α protein expression and oxidative stress (OS) in brain areas related to memory, as well as the correlation between them. A reduction in short- and long-term recognition memory (STM and LTM) performance, as well as in total exploration time was observed in TBT mice. Reduced ERα protein expression was observed in the prefrontal cortex (PFC) and hippocampus of TBT mice, while an increase in TBARS concentration was observed in the PFC of treated animals. Collectively, these data suggest that TBT exposure impairs recognition memory in female mice as a result of, at least in part, its toxicological effects on ERα expression and OS in specific brain areas related to memory.

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Activation of ERα and/or ERβ ameliorates cognitive impairment and apoptosis in streptozotocin-induced diabetic mice

Cited by 12 publications

References 55 publications

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

mTOR‐mediated autophagy in the hippocampus is involved in perioperative neurocognitive disorders in diabetic rats

Tributyltin Exposure Is Associated With Recognition Memory Impairments, Alterations in Estrogen Receptor α Protein Levels, and Oxidative Stress in the Brain of Female Mice

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