Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Echeverrı́a, Valentina; Echeverria, Florencia; Barreto, George E.; Echeverría, Javier; Mendoza, Cristhian

doi:10.3389/fphar.2021.644103

Cited by 21 publications

(17 citation statements)

References 220 publications

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“…The STZ administration, followed by chronic 21-day treatment with GPER agonist daidzein, increases the navigation time in the target quadrant and decreases the latency time to find the platform in Morris water maze (Wei et al, 2019 ). This study underlines the therapeutic potential of phytoestrogens in cognitive disorders (Echeverria et al, 2021 ).…”

Section: Pathological Models Induced Cognitive Alterationssupporting

confidence: 68%

“…The neuroprotective efficacy of HT remains unclarified. Considering that in the next decade, there would be 1.2 billion of menopausal and post-menopausal women (Hampson, 2018 ; Echeverria et al, 2021 ), it is necessary to standardize the cognitive task to be carried out in this population along with the pharmacological treatments to use. In humans, cognitive ability can be assessed by the mental rotation task (MRT) which considers perception, identification, orientation, judgment, response, and execution processes (Xue et al, 2017 ).…”

Section: Estrogens and Cognitive Tasks In Humansmentioning

confidence: 99%

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Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection?

Marchant

Chabert

Martínez-Pinto

et al. 2022

Front. Cell. Neurosci.

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Menopause transition can be interpreted as a vulnerable state characterized by estrogen deficiency with detrimental systemic effects as the low-grade chronic inflammation that appears with aging and partly explains age-related disorders as cancer, diabetes mellitus and increased risk of cognitive impairment. Over the course of a lifetime, estrogen produces several beneficial effects in healthy neurological tissues as well as cardioprotective effects, and anti-inflammatory effects. However, clinical evidence on the efficacy of hormone treatment in menopausal women has failed to confirm the benefit reported in observational studies. Unambiguously, enhanced verbal memory is the most robust finding from longitudinal and cross-sectional studies, what merits consideration for future studies aiming to determine estrogen neuroprotective efficacy. Estrogen related brain activity and functional connectivity remain, however, unexplored. In this context, the resting state paradigm may provide valuable information about reproductive aging and hormonal treatment effects, and their relationship with brain imaging of functional connectivity may be key to understand and anticipate estrogen cognitive protective effects. To go in-depth into the molecular and cellular mechanisms underlying rapid-to-long lasting protective effects of estrogen, we will provide a comprehensive review of cognitive tasks used in animal studies to evaluate the effect of hormone treatment on cognitive performance and discuss about the tasks best suited to the demonstration of clinically significant differences in cognitive performance to be applied in human studies. Eventually, we will focus on studies evaluating the DMN activity and responsiveness to pharmacological stimulation in humans.

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Section: Pathological Models Induced Cognitive Alterationssupporting

confidence: 68%

Section: Estrogens and Cognitive Tasks In Humansmentioning

confidence: 99%

Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection?

Marchant

Chabert

Martínez-Pinto

et al. 2022

Front. Cell. Neurosci.

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“…In addition, plant-based diets are rich in phytoestrogens, which are plant compounds found in some seeds, legumes and some fruits and vegetables. Phytoestrogens have been shown to mimic the benefits of endogenous estrogens, and diets rich in phytoestrogens are considered promising approaches to alleviate menopausal symptoms (Echeverria et al , 2021) and reduce the risk of postmenopausal cardiovascular disease (de Kleijn et al , 2002).…”

Section: Discussionmentioning

confidence: 99%

High plant-based diet and physical activity in women during menopausal transition

Lombardo¹,

Rizzo²,

Feraco³

et al. 2021

NFS

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Purpose The menopausal transition (MT) is a period when there may be an increase in visceral fat mass and a worsening of cardiometabolic risk factors. Few studies have evaluated the efficacy of plant-based low-calorie diets on groups of women at different stages of MT. The purpose of this study is to compare the effectiveness of a high plant-to-animal protein ratio diet in women of similar age but with different fertility statuses. Design/methodology/approach Subjects were divided into three groups according to their fertility status at the baseline: “premenopausal” (n = 11), “perimenopause” (n = 14) and “postmenopause” (n = 18). Body composition (BC) was measured at the beginning and after eight months of treatment. Individualised lifestyle treatment included a strong component of plant-based foods. Findings Forty-three overweight or obese Caucasian women (age 52.3 ± 4.5 years, body mass index 30.6 ± 5.4 kg/m2, fat mass 33.1 ± 9.3 kg data presented as means ± SD) were included in the study. Mean physical activity was 8.4 ± 7.6 metabolic equivalent of tasks/week. Subjects had an improvement in BC (fat mass −5.6 ± 4.0 kg, p < 0.001 protein −0.3 ± 0.5 kg, p < 0.001), HDL-C and systolic blood pressure values. Waist circumference and hip circumference decreased by 4.1 ± 3.1 cm and −6.0 ± 4.3 cm, respectively. Weight loss resulted in a significant improvement in some blood lipid values, such as total and high-density lipoprotein cholesterol. Adherence to a high plant protein diet helps adult women with different fertility statuses to improve BC and reduce cardiovascular risk factors. Long-term studies with larger sample sizes are needed to confirm these findings. Originality/value In pre-peri- and post-menopausal adult women, a diet high in plant proteins improves body composition and reduces cardiovascular risk factors.

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“…The consequential brain damage results in many undesirable symptoms, such as cognitive impairment, sleep disorders, anxiety, and depression. These symptoms are frequent in women who have had their ovaries removed or have reached menopausal age [5][6][7]. On the other hand, several studies have proven that estrogen and testosterone regulate HPA axis responses by buffering glucocorticoid feedback [8].…”

Section: Introductionmentioning

confidence: 99%

Effect of Yakae-Prajamduen-Jamod Traditional Thai Remedy on Cognitive Impairment in an Ovariectomized Mouse Model and Its Mechanism of Action

et al. 2022

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Cognitive impairment is a neurological symptom caused by reduced estrogen levels in menopausal women. The Thai traditional medicine, Yakae-Prajamduen-Jamod (YPJ), is a formula consisting of 23 medicinal herbs and has long been used to treat menopausal symptoms in Thailand. In the present study, we investigated the effects of YPJ on cognitive deficits and its underlying mechanisms of action in ovariectomized (OVX) mice, an animal model of menopause. OVX mice showed cognitive deficits in the Y-maze, the novel object recognition test, and the Morris water maze. The serum corticosterone (CORT) level was significantly increased in OVX mice. Superoxide dismutase and catalase activities were reduced, while the mRNA expression of IL-1β, IL-6, and TNF-α inflammatory cytokines were up-regulated in the frontal cortex and hippocampus of OVX mice. These alterations were attenuated by daily treatment with either YPJ or 17β-estradiol. HPLC analysis revealed that YPJ contained antioxidant and phytoestrogen constituents including gallic acid, myricetin, quercetin, luteolin, genistein, and coumestrol. These results suggest that YPJ exerts its ameliorative effects on OVX-induced cognitive deficits in part by mitigating HPA axis overactivation, neuroinflammation, and oxidative brain damage. Therefore, YPJ may be a novel alternative therapeutic medicine suitable for the treatment of cognitive deficits during the menopausal transition.

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Estrogenic Plants: to Prevent Neurodegeneration and Memory Loss and Other Symptoms in Women After Menopause

Cited by 21 publications

References 220 publications

Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection?

Estrogen, Cognitive Performance, and Functional Imaging Studies: What Are We Missing About Neuroprotection?

High plant-based diet and physical activity in women during menopausal transition

Effect of Yakae-Prajamduen-Jamod Traditional Thai Remedy on Cognitive Impairment in an Ovariectomized Mouse Model and Its Mechanism of Action

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