Activation of cholinergic basal forebrain neurons improved cognitive functions in adult-onset hypothyroid mice

Xu, Yaping; Wang, Can; Li, J.; Guo, Wei; Li, Guoying; Zhang, Huabing; Sun, Yan; Zhu, Dawei; Xu, Qi

doi:10.1016/j.biopha.2022.113495

Cited by 6 publications

(8 citation statements)

References 46 publications

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“…The Animal Care and Use Committee of Anhui Medical University approved all animal experiments, and all experimental procedures were carried out in accordance with the Anhui Medical University Animal Experiment Guide, as previously described ( 23 , 24 ). The C57BL/6 male mice (8–10 weeks old) required for the experiment were purchased from the Anhui Provincial Laboratory Animal Center, China (Certificate No.…”

Section: Methodsmentioning

confidence: 99%

“…The procedure for EEG/EMG electrodes implantation was as previously described (23,25). In brief, all mice were anesthetized with isoflurane and fixed on a stereotaxic apparatus (68,043, RWD Life Science, Shenzhen, China), and two stainless steel pins for EEG recording were inserted into the skulls of the right frontal cortex and the right parietal cortex.…”

Section: Eeg/emg Electrodes Implantationmentioning

confidence: 99%

“…The EEG and EMG signals were amplified, filtered, acquired, and digitized at a sampling rate of 128 Hz, and recorded using Vitalrecorder software (Kissei Comtec Co., Ltd., Japan). After the recording was completed, SleepSign software (Kissei Comtec Co., Ltd., Japan) was used to parse the EEG/ EMG signals into NREM sleep, REM sleep, and wakefulness phases using an epoch of 4 s, according to the criteria previously reported (23,32). All phases were manually rechecked and corrected.…”

Section: Sleep-wake Cycle Recording and Scoringmentioning

confidence: 99%

“…Exposing mice to social stress or foot-shock stress results in increased wakefulness in the initial phase, followed by an altered sleep architecture, including prolonged NREM sleep or REM sleep (19)(20)(21). These results indicate that stressors are pathological factors that increase the risk of disturbing sleep and emotion, which may increase the development of dementia and metabolic and cardiovascular diseases (22,23). Nevertheless, the role and potential regulatory mechanisms of stress-induced mood and sleep alterations have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Restraint stress induced anxiety and sleep in mice

et al. 2023

Front. Psychiatry

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In humans and animals, exposure to changes in internal or external environments causes acute stress, which changes sleep and enhances neurochemical, neuroendocrine, and sympathetic activities. Repeated stress responses play an essential role in the pathogenesis of psychiatric diseases and sleep disorders. However, the underlying mechanism of sleep changes and anxiety disorders in response to acute stress is not well established. In the current study, the effects of restraint stress (RS) on anxiety and sleep–wake cycles in mice were investigated. We found that after RS, the mice showed anxiety-like behavior after RS manipulation and increased the amounts of both non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in the dark period. The increase in sleep time was mainly due to the increased number of episodes of NREM and REM sleep during the dark period. In addition, the mice showed an elevation of the EEG power spectrum of both NREM and REM sleep 2 h after RS manipulation. There was a significant reduction in the EEG power spectrum of both NREM and REM sleep during the darkperiod in the RS condition. The expression of the c-Fos protein was significantly increased in the parabrachial nucleus, bed nucleus of the stria terminalis, central amygdala, and paraventricular hypothalamus by RS manipulation. Altogether, the findings from the present study indicated that neural circuits from the parabrachial nucleus might regulate anxiety and sleep responses to acute stress, and suggest a potential therapeutic target for RS induced anxiety and sleep alterations.

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Section: Methodsmentioning

confidence: 99%

Section: Eeg/emg Electrodes Implantationmentioning

confidence: 99%

Section: Sleep-wake Cycle Recording and Scoringmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Restraint stress induced anxiety and sleep in mice

et al. 2023

Front. Psychiatry

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“…A selective ligand of choice for DREADDs is clozapine N-oxide (CNO) [ 147 ]. To investigate how the brain works and behaves, this method has frequently been employed to control the activity of different types of neurons [ 148 , 149 ]. However, nowadays, it is a unique study paradigm to control astrocyte GPCR signaling [ 150 , 151 ].…”

Section: Novel Therapeutic Strategies To Target Astrocyte Dysfunction...mentioning

confidence: 99%

Astrocytic MicroRNAs and Transcription Factors in Alzheimer’s Disease and Therapeutic Interventions

Nassar

Kodi

Satarker

et al. 2022

Cells

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Astrocytes are important for maintaining cholesterol metabolism, glutamate uptake, and neurotransmission. Indeed, inflammatory processes and neurodegeneration contribute to the altered morphology, gene expression, and function of astrocytes. Astrocytes, in collaboration with numerous microRNAs, regulate brain cholesterol levels as well as glutamatergic and inflammatory signaling, all of which contribute to general brain homeostasis. Neural electrical activity, synaptic plasticity processes, learning, and memory are dependent on the astrocyte–neuron crosstalk. Here, we review the involvement of astrocytic microRNAs that potentially regulate cholesterol metabolism, glutamate uptake, and inflammation in Alzheimer’s disease (AD). The interaction between astrocytic microRNAs and long non-coding RNA and transcription factors specific to astrocytes also contributes to the pathogenesis of AD. Thus, astrocytic microRNAs arise as a promising target, as AD conditions are a worldwide public health problem. This review examines novel therapeutic strategies to target astrocyte dysfunction in AD, such as lipid nanodiscs, engineered G protein-coupled receptors, extracellular vesicles, and nanoparticles.

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