Actions of Hyperalgesic Substances {(-)Naloxone, Theophylline and 5-Methoxy-N,n- Dimethyltryptamine} on Nociceptive Learning

Ramabadran, K.; Guillon, J.-C.; Jacob, J.

doi:10.1016/b978-0-08-025488-3.50120-3

Cited by 7 publications

(8 citation statements)

References 5 publications

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“…The findings further demonstrate that one-trial learning occurs in this apparatus, and that it is particularly robust when the escape response is assayed. The data also show, in agreement with those of Ramabadran et al (1979), that opiate antagonists enhance learning of hot-plate responding when jump latencies are measured. When escape responding is measured, no naltrexone effects are observable on test trials, probably because escape latencies of salineinjected mice are already quite low.…”

Section: Discussionsupporting

confidence: 84%

“…Numerous experiments from Jacob's laboratory have demonstrated that the antagonists naloxone or Mr 2266 stereospecifically reduce jump response latencies of mice placed on a hot plate when administered prior to an initial exposure (Jacob and Ramabadran 1978;Jacob et al 1974;Ramabadran et al 1979). Preliminary results from this laboratory indicate that latencies remain reduced upon reexposure to the hot plate in the absence of drug (Ramabadran et al 1979). Nonopiate-related drugs that produced hyperalgesia on the first hot-plate exposure (theophylline or 5-methoxy-N,N-dimethyltryptamine) did not affect long-term jump responding.…”

mentioning

confidence: 99%

“…Nonopiate-related drugs that produced hyperalgesia on the first hot-plate exposure (theophylline or 5-methoxy-N,N-dimethyltryptamine) did not affect long-term jump responding. Therefore, Ramabadran et al (1979) hypothesized that the long-term facilitation of jump responding by opiate antagonists is independent of their hyperalgesic activity. To test this hypothesis, these investigators measured the effects of naloxone, given after an initial hot-plate trial, on subsequent jump responding.…”

mentioning

confidence: 99%

“…Because memory consolidation is thought to occur over an extended time period of several hours, we used the long-acting opiate antagonist naltrexone rather than naloxone, which was used by Ramabadran et al (1979).…”

mentioning

confidence: 99%

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Facilitation of hot-plate response learning by pre- and posttraining naltrexone administration

Messing¹,

Rijk²,

Rigter³

1983

Psychopharmacology

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Retention performance for shock-motivated learning is generally enhanced by opiate antagonists. To test the hypothesis that opioid systems mediate learning and memory in nonshock-motivated tasks, the effects of naltrexone on hot-plate response learning were investigated. Naltrexone (0.1 or 1.0 mg/kg IP) 10 min before hot-plate exposure produced hyperalgesia, as measured by decreased latencies of naltrexone-injected mice to escape. Jump latencies, however, were not significantly decreased by naltrexone given 10 min before initial testing. Nevertheless, jump latencies of naltrexone-injected mice, but not saline-injected mice, decreased further on subsequent test trials 1 and 4 days later although treatment was discontinued, suggesting that the opiate antagonist also influenced learning or memory. Mice given naltrexone (0.3-10.0 mg/kg IP) immediately after their first hot-plate exposure also exhibited learning of the jump response, on a test trial 48 h later. The decreases in jump latencies on test trials were smaller after posttraining, than pretraining naltrexone administration. The results indicate that the effect of naltrexone on learning and memory can be at least partially separated from its hyperalgesic activity.

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Section: Discussionsupporting

confidence: 84%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Facilitation of hot-plate response learning by pre- and posttraining naltrexone administration

Messing¹,

Rijk²,

Rigter³

1983

Psychopharmacology

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“…After placing the mouse on the hot plate, the reaction times for pawlicking and escape attempt (jump) were recorded in seconds. In order to obviate the effect of learning Ramabadran et al 1979;Messing et al 1983), latency times were determined in separate groups of mice, 15 min after vehicle and naloxone (0.3, 1 and 3 mg/kg) treatment . A cut-off time of 60 s was used.…”

Section: Methodsmentioning

confidence: 99%

The hyperalgesic effect of naloxone is attenuated in streptozotocin-diabetic mice

et al. 1989

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In mice with streptozotocin-induced hyperglycemia, nociception was tested after naloxone administration in hot plate and tail immersion tests. The choice of these two tests was to include a supra-spinal nociceptive reflex indicative of higher cognitive process (hot-plate test) as well as a reflex which predominantly represents lower spinal motor mechanisms (tail immersion test). Naloxone-induced hyperalgesia was attenuated in both tests in mice with streptozotocin-induced diabetes. In mice with hyperglycemia induced by intraperitoneal dextrose administration, naloxone hyperalgesia was significantly enhanced in the hot plate test. The basal nociceptive threshold in streptozotocin-treated animals was decreased in the immersion but not in the hot plate test. These results indicate that hyperglycemia per se does not adequately explain the changes in naloxone hyperalgesia in experimental models of diabetes. They also suggest that acute hyperglycemia may modify the interaction of endogenous opioid peptides with their receptors only at supra-spinal sites. However, chronic hyperglycemia appears to affect endogenous opioid peptides both at spinal and supra-spinal levels and their interaction with the opiate receptors.

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Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat

Rochford

2000

Psychopharmacology

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Actions of Hyperalgesic Substances {(-)Naloxone, Theophylline and 5-Methoxy-N,n- Dimethyltryptamine} on Nociceptive Learning

Cited by 7 publications

References 5 publications

Facilitation of hot-plate response learning by pre- and posttraining naltrexone administration

Facilitation of hot-plate response learning by pre- and posttraining naltrexone administration

The hyperalgesic effect of naloxone is attenuated in streptozotocin-diabetic mice

Selective mu and delta, but not kappa, opiate receptor antagonists inhibit the habituation of novelty-induced hypoalgesia in the rat

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