The hyperalgesic effect of naloxone is attenuated in streptozotocin-diabetic mice

Ramabadran, K.; Bansinath, M.; Turndorf, Herman; Puig, Margarita M.

doi:10.1007/bf00442244

Cited by 60 publications

(30 citation statements)

References 37 publications

(38 reference statements)

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“…Any animal not responding after 15 s was excluded from the study. The hyperalgesic response in the tail-withdrawal test is generally attributed to central mechanisms (22,23). …”

Section: Methodsmentioning

confidence: 99%

Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

Gürsoy

Özdemir

Bağcıvan

et al. 2011

Upsala Journal of Medical Sciences

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BackgroundAlpha 2 (α2)-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (α2-adrenoceptor agonists) on morphine analgesia and tolerance in rats.MethodsAdult male Wistar albino rats weighing 195–205 g were used. To constitute morphine tolerance, animals received morphine (50 mg/kg) once daily for 3 days. After the last dose of morphine had been injected on day 4, morphine tolerance was evaluated by analgesia tests. The analgesic effects of dexmedetomidine (20 μg/kg), guanfacine (0.5 mg/kg), MK-467 (0.25 mg/kg), and morphine were estimated at 30-min intervals (0, 30, 60, 90, and 120 min) by tail-flick and hot-plate analgesia tests.ResultsOur findings indicate that dexmedetomidine and guanfacine attenuated the expression of morphine tolerance. In addition, administration of dexmedetomidine with morphine increased morphine analgesia. On the contrary, data suggested that MK-467 (an α2-adrenoceptor antagonist) decreased morphine analgesia and increased morphine tolerance in analgesia tests.ConclusionIn conclusion, we observed that co-injection of dexmedetomidine or guanfacine with morphine attenuated the expression of tolerance to the analgesic effect of morphine and that dexmedetomidine enhanced the morphine analgesia.

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“…Any animal not responding after 15 s was excluded from the study. The hyperalgesic response in the tail-withdrawal test is generally attributed to central mechanisms (22,23). …”

Section: Methodsmentioning

confidence: 99%

Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

Gürsoy

Özdemir

Bağcıvan

et al. 2011

Upsala Journal of Medical Sciences

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“…Diabetes mellitus was induced by the single intraperitoneal injection (200 mg kg/wt) of streptozotocin (25). Random blood glucose levels were measured 1 week after the first STZ injection using a glucometer (Accu-Check, Roche Diagnostics).…”

Section: Animalsmentioning

confidence: 99%

Sonoporation of the Minicircle-VEGF165 for Wound Healing of Diabetic Mice

et al. 2008

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“…Shortening of the tail withdrawal time indicates hyperalgesia and is attributed to central mechanisms. [23] Hot Plate Test…”

Section: Tail Immersion Testmentioning

confidence: 99%

Polyphenolic Extract ofIchnocarpus FrutescensAttenuates Diabetic Complications in Streptozotocin-Treated Diabetic Rats

Kumarappan

Mandal

2008

Renal Failure

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Diabetic nephropathy is one of the major complications of diabetes. Oxidative stress is implicated as an important mechanism by which diabetes causes nephropathy. The aim of the study was to examine the involvement of oxidative stress in the progression of nephropathy in STZ diabetic animals and to evaluate the potential of polyphenolic extract (PPE) in the treatment of diabetes mellitus. In this study, we examined whether prolonged oral administration of polyphenolic extract of Ichnocarpus frutescens could prevent the progress or improve the outcome of diabetic nephropathy induced by oxidative stress in STZ diabetic rats. Intraperitoneal glucose tolerance test (IPGTT) revealed a significant decrease in blood glucose levels at 180 min after glucose loading in Wistar albino rats fed with PPE. During the eight weeks of experimental period, diabetic rats exhibited wide range of symptoms, including loss of body weight, hyperglycemia, polyuria, proteinuria, renal enlargement, and total renal dysfunction. A significant increase in TBARS level was observed in diabetic kidney, which was accompanied by a significant decrease in enzymatic and non-enzymatic antioxidant levels. After eight weeks, PPE-treated groups showed a lower level of blood glucose compared with non-treated STZ diabetic rats. The increases in urinary albumin and protein after eight weeks of treatment were significantly inhibited by prolonged treatment with PPE. In addition, PPE attenuates the adverse effects on hepatic biomarkers. We found that PPE can effectively protect against aldose reductase activity and protein damage (albumin glycation), and showed that its action was mainly due to enriched polyphenolic content. Our results also showed that treatment with PPE normalized the increase in hyperalgesia (i.e., the response to thermal stimuli) associated with the induction of diabetes by STZ. PPE administration in diabetic rats clearly ameliorated diabetic complications, suggesting not only a natural antioxidant but also supportive therapy for the treatment of type II diabetes.

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The hyperalgesic effect of naloxone is attenuated in streptozotocin-diabetic mice

Cited by 60 publications

References 37 publications

Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

Effects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats

Sonoporation of the Minicircle-VEGF165 for Wound Healing of Diabetic Mice

Polyphenolic Extract ofIchnocarpus FrutescensAttenuates Diabetic Complications in Streptozotocin-Treated Diabetic Rats

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