Actions of Goldfish Neuropeptide Y on the Secretion of Growth Hormone and Gonadotropin-II in Female Goldfish

Peng, Chun; Humphries, Sophia Monica; Peter, Richard; Rivier, Jean; Blomqvist, Anders; Larhammar, Dan

doi:10.1006/gcen.1993.1086

Cited by 79 publications

(32 citation statements)

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“…SS-14 inhibits basal (52) and stimulated GH release in vitro (34) in the goldfish. The inhibitory actions of SS-14 on ghrelinstimulated GH release provide further evidence for the direct actions of ghrelin on goldfish pituitary cells.…”

Section: Role Of Ss-14 On Ghrelin-induced Gh Releasementioning

confidence: 95%

In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish

Unniappan¹,

Peter²

2004

American Journal of Physiology-Regulatory, Integrative and Comp

108

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Section: Role Of Ss-14 On Ghrelin-induced Gh Releasementioning

confidence: 95%

In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish

Unniappan¹,

Peter²

2004

American Journal of Physiology-Regulatory, Integrative and Comp

108

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“…Some studies have reported that NPY is involved in the neuroendocrine regulation of growth hormone. For example, NPY stimulates GH secretion in vitro and in vivo in goldfish (Peng et al, 1993b;Peng et al, 1993a) and catfish (Mazumdar et al, 2006). Similar as in mammals, NPY also interacts with a number of appetite factors, e.g.…”

Section: Discussionmentioning

confidence: 97%

“…And this result is also highly consistent with those reported in other fish species. For example, injections of mammal NPY or fish NPY promoted food intake of goldfish (Narnaware et al, 2000;Peng et al, 1993a) and rainbow trout (Aldegunde and Mancebo, 2006). Moreover, our study also showed that the FCRs of tilapia fed with 0.15 or 0.3μg/g feed of TiNPY1 and fed with 0.3μg/g feed of TiNPY2 were significantly lower than the control group, which perhaps suggests some significance in the aquaculture of tilapia.…”

Section: Discussionmentioning

confidence: 99%

Expression of Neuropeptide Y of GIFT Tilapia (Oreochromis sp.) in Yeast Pichia Pastoris and Its Stimulatory Effects on Food Intake and Growth

Wang¹,

Sun²,

Lin³

et al. 2011

Update on Mechanisms of Hormone Action - Focus on Metabolism, Growth and Reproduction

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“…In goldfish, GH release is under the stimu latory control of multiple hypothalamic factors [1,10,11,29,[33][34][35][36][37], One of these factors, dopamine has been shown to act via D1 type of receptors to stimulate GH release [35,37], Similarly, TRH stimulates GH secretion from the perifused goldfish pituitary fragments in a dosedependent manner [34], When tested, both SKF38393 (dopamine D1 type agonist) and TRH-stimulated GH secretion from the perifused pituitary fragments. Analog L at 2 \iM had no significant effects on GH release induced either by SKF38393 or by TRH.…”

Section: Discussionmentioning

confidence: 99%

Differential Actions of a Mammalian Gonadotropin-Releasing Hormone Antagonist on Gonadotropin-ll and Growth Hormone Release in Goldfish, <i>Carassius auratus</i>

et al. 1994

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In goldifish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1, 2, 3, and 6 often result in an antagonist in goldfish, an observation well documented in mammalian studies. In a preliminary study in goldfish, a mammalian GnRH antagonist, [Ac-D(2)Nal¹, 4Cl-D-Phe², D(3)-Pal^3,6, Arg⁵, D-Ala¹⁰]-mGnRH (analog L) weakly stimulated GTH-II release, and strongly inhibited GH release. The objectives of the present study were to study the dose-related actions of analog L on GTH-II and GH release in the goldfish, the specificity of inhibition of native GnRH actions, and to test whether analog L can act directly on goldfish pituitary cells. In a goldfish pituitary fragments perifusion system, analog L at different concentrations, given as 2-min pulses or as 30-min prolonged treatments, stimulated GTH-II and inhibited GH release in a dose-dependent manner. Analog L at 2 µM concentration (45 min) significantly suppressed sGnRH- and cGnRH-II-stimulated GTH-II as well as GH release. Analog L specifically inhibited GnRH-stimulated GH release, without having any significant effects on the GH release induced by either SKF38393, a dopamine Dl receptor agonist, or thyrotropin-releasing hormone. The GTH-II stimulatory and GH-inhibitory actions of analog L were significantly suppressed by a ‘true’ GnRH antagonist (Ac-Δ³-Pro¹, 4FD-Phe², D-Trp^3,6)-mGnRH. Further, analog L stimulated GTH-II release and suppressed GH release from the enzymatically dispersed goldfish pituitary cells, indicating the direct actions of analog L at the pituitary cell level. Analog L also displaced ¹²⁵I-(D-Arg⁶, Pro⁹ NHEt)-sGnRH bound to crude goldfish pituitary membrane preparations in a dose-related manner. In conclusion, contrary to its action as a potent GnRH antagonist in mammals, analog L has GTH-II stimulatory action in goldfish. Analog L by acting via GnRH receptors at the pituitary cell level differentially acts on GTH-II and GH release, suggesting functional differences in the properties of the GnRH receptors on GTH and GH cells. Analog L also specifically inhibits sGnRH and cGnRH-II actions on GTH-II and GH release.

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Actions of Goldfish Neuropeptide Y on the Secretion of Growth Hormone and Gonadotropin-II in Female Goldfish

Cited by 79 publications

References 0 publications

In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish

In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish

Expression of Neuropeptide Y of GIFT Tilapia (Oreochromis sp.) in Yeast Pichia Pastoris and Its Stimulatory Effects on Food Intake and Growth

Differential Actions of a Mammalian Gonadotropin-Releasing Hormone Antagonist on Gonadotropin-ll and Growth Hormone Release in Goldfish, <i>Carassius auratus</i>

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