Differential Actions of a Mammalian Gonadotropin-Releasing Hormone Antagonist on Gonadotropin-ll and Growth Hormone Release in Goldfish, <i>Carassius auratus</i>
Abstract:In goldifish the two native forms of gonadotropin-releasing hormone (GnRH), salmon GnRH (sGnRH) and chicken GnRH-II (cGnRH-II), stimulate both gonadotropin-II (GTH-II) and growth hormone (GH) release. Modifications of GnRH structure at positions 1, 2, 3, and 6 often result in an antagonist in goldfish, an observation well documented in mammalian studies. In a preliminary study in goldfish, a mammalian GnRH antagonist, [Ac-D(2)Nal1, 4Cl-D-Phe2, D(3)-Pal3,6, Arg5, D-Al… Show more
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