Action of niceritrol (pentaerythritoltetranicotinate) on lipid accumulation in aortas of cholesterol-fed rabbits independent of contemporary reduction of serum lipids

Brattsand, Ralph; Petersen, H; Lundholm, Lennart

doi:10.1016/0021-9150(74)90028-8

Cited by 14 publications

(4 citation statements)

References 10 publications

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“…10 times the normal value [15], as described by Bran sand et at. [16], After 3 weeks the control animals got a restrained amount of food to keep their weight gain down at the level of the CRF animals, which did not thrive well.…”

Section: Individually Adjusted Cholesterol Feedingmentioning

confidence: 99%

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Kamstrup¹,

Tvedegaard²,

Stender³

1980

Nephron

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14 rabbits were made uremic by extensive cauterization and subsequent removal of the contralateral kidney, resulting in a mean plasma creatinine concentration four times the value observed in a sham-operated control group. The animals were killed after 10 weeks of uremia. During the last 7 weeks the rabbits were fed an individually adjusted amount of cholesterol in order to maintain the same elevated level of plasma cholesterol in both groups. The triglyceride concentration was four times higher in the uremic than in the control group. In spite of the same average level of total plasma cholesterol the uremic rabbits had a lower concentration of cholesterol in the VLDL-fraction than the controls. None of the aortas had intimal lesions macroscopically. There were no significant differences between the two groups in the 48-hour accumulation of radioactive cholesterol or in the amount of free and esterified cholesterol in the aortas. Thus, no significant effect on cholesterol accumulation by uremia in the aorta of hypercholesterolemic rabbits was demonstrated.

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Section: Individually Adjusted Cholesterol Feedingmentioning

confidence: 99%

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Kamstrup¹,

Tvedegaard²,

Stender³

1980

Nephron

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“…The procedure was originally used by Brattsand et al 13 in a drug trial. It was later used in rabbits to test whether exogenous cholesterol differs in atherogenic potential from endogenously synthesized cholesterol.…”

mentioning

confidence: 99%

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

et al. 1988

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Two groups of 18 rabbits were fed Isocalorlc, cholesterol-enriched diets for 8 weeks. The diet for one group was supplemented with 5% corn oil. The concentration of cholesterol in plasma was determined weekly and the amount of cholesterol In the diet was adjusted Individually so that each rabbit had a mean plasma cholesterol concentration of about 45 mM during the experimental period. The aortic cholesterol concentrations were 122 ± 29 and 193 ± 38 (mean ± SEM) /xmol/g protein for the cornoil group and the control group, respectively (p<0.05). In a similar experiment, each of 36 rabbits was given a mean plasma cholesterol level of about 20 mM over a period of 12 weeks. One-third of the rabbits received 10% to 15% corn oil, another third 10% to 15% olive oil, while the last third served as a control group. The aortic cholesterol concentrations were 98 ± 25, 57 ± 9, and 131 ± 32 ^mol/g protein, respectively. The value for the olive-oil group was significantly (p<0.01) lower than the value for the control group. The trlglycerlde concentrations and the distributions of cholesterol between HDL, LDL, and VLDL In plasma showed no significant differences between the plant-oil groups and their control groups. This suggests that plant oils have a direct effect on the aortic cholesterol metabolism. (Arteriosclerosis 8:281-287, May/June 1988)

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“…The first evidence that NA administration reduced atherosclerosis was reported in rabbits [ 130 , 131 , 132 , 133 ] and minipigs [ 134 ] ( Table 1 ). The antiatherogenic effect of NA was also confirmed in humans [ 135 , 136 ].…”

Section: In Vivo Cardiovascular Effects Of Nad+-boosting Strategies: Lessons From Animal Modelsmentioning

confidence: 99%

“…Originally, these antiatherogenic effects were mainly attributed to the ability of NA to reduce serum LDL cholesterol (LDL-C) and triglycerides while increasing HDL-C levels. However, these antiatherogenic effects did not always correlate with NA-mediated hypolipidemic effects [ 130 , 134 ]. The development of genetically engineered mice permitted us to evaluate the potential of NA to prevent massive atherosclerosis in different mouse models of hyperlipidemia and investigate the potential atheroprotective mechanisms.…”

Section: In Vivo Cardiovascular Effects Of Nad+-boosting Strategies: Lessons From Animal Modelsmentioning

confidence: 99%

Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases

et al. 2021

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Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. NAD+ bioavailability decreases with age and cardiometabolic conditions in several mammalian tissues. Compelling data suggest that declining tissue NAD+ is commonly related to mitochondrial dysfunction and might be considered as a therapeutic target. Thus, NAD+ replenishment by either genetic or natural dietary NAD+-increasing strategies has been recently demonstrated to be effective for improving the pathophysiology of cardiac and vascular health in different experimental models, as well as human health, to a lesser extent. Here, we review and discuss recent experimental evidence illustrating that increasing NAD+ bioavailability, particularly by the use of natural NAD+ precursors, may offer hope for new therapeutic strategies to prevent and treat cardiovascular diseases.

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Action of niceritrol (pentaerythritoltetranicotinate) on lipid accumulation in aortas of cholesterol-fed rabbits independent of contemporary reduction of serum lipids

Cited by 14 publications

References 10 publications

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

Therapeutic Potential of Emerging NAD+-Increasing Strategies for Cardiovascular Diseases

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