Effect of Chronic Uremia on Plasma Lipids and the Aortic Accumulation of Cholesterol in Hypercholesterolemic Rabbits

Abstract

14 rabbits were made uremic by extensive cauterization and subsequent removal of the contralateral kidney, resulting in a mean plasma creatinine concentration four times the value observed in a sham-operated control group. The animals were killed after 10 weeks of uremia. During the last 7 weeks the rabbits were fed an individually adjusted amount of cholesterol in order to maintain the same elevated level of plasma cholesterol in both groups. The triglyceride concentration was four times higher in the uremic than in the control group. In spite of the same average level of total plasma cholesterol the uremic rabbits had a lower concentration of cholesterol in the VLDL-fraction than the controls. None of the aortas had intimal lesions macroscopically. There were no significant differences between the two groups in the 48-hour accumulation of radioactive cholesterol or in the amount of free and esterified cholesterol in the aortas. Thus, no significant effect on cholesterol accumulation by uremia in the aorta of hypercholesterolemic rabbits was demonstrated.

Inhibition by Methylprednisolone Treatment of the Aortic Mineral Accumulation in Rabbits with Chronic Renal Failure

“…The cholesterol content of the rabbit aorta was found to be unaffected by CRF, in agreement with previous reports (Kamstrup et al 1980). The finding that the aortic content of cholesterol was also unaffected by methylprednisolone could be due to the moderate dosage and limited treatment period.…”

“…In a series of investigations the arterial disease seen in rabbits with chronic renal failure (CRF) has been characterized (Kamstrup et al 1980;Tvedegaard et a/. 1983a;Kamstrup & Tvedegaard 1983; Tvedegaard et a/.…”

Effect of 1α-Hydroxyvitamin D₃ and Dietary Calcium and Phosphate on the Aortic Mineral Content in Rabbits with Mild Azotemia

“…CRF was induced in 48 rabbits by cauterization of one half to two thirds of the left kidney with contralateral nephrec tomy 3 weeks later [16]. 16 control rabbits with normal renal function were sham-operated twice.…”

“…CRF was induced in 48 rabbits by cauterization of one half to two thirds of the left kidney with contralateral nephrec tomy 3 weeks later [16]. 16 control rabbits with normal renal function were sham-operated twice. The rabbits were housed in individual cages and received daily 100 g of standard rabbit pellets (Boserup®; Faxe, Denmark), containing 3% fat, 1.2% Ca, 0.6% P and 0.2% Mg with 200 IU of vitamin D3 per 100 g. The rabbits had free access to tap water.…”

No Effect of Low‐dose 1α‐Hydroxycholecalciferol Treatment on the Renal Function Deterioration Rate in Long‐term Uraemic Rabbits

“…Male rabbits of the Danish Country strain weighing 3-3.5 kg were used. Uraemia was induced by cauterization of 2/3 of the left kidney with subsequent contralateral nephrectomy (Kamstrup et a/. 1980).…”