1976
DOI: 10.1016/0009-8981(76)90062-0
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Action of metabolic inhibitors on the release of intra-cellular enzymes from human and rat lymphocytes and human erythrocytes

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1976
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Cited by 12 publications
(5 citation statements)
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“…Acosta et al (1978) showed with primary monolayer cultures of postnatal rat myocardial cells that complete deprivation of glucose and oxygen caused marked release of cytoplasmic enzymes, and that enzyme leakage was reversed by a change to complete medium and an atmosphere of 20% 02. Hallak and Wilkinson (1976) examined the effects of various inhibitors of glycolysis and uncouplers of oxidative phosphorylation and found that release of intracellular enzymes was controlled by the energy level of the cells. In contrast to the effects of these compounds on enzyme leakage by primary effects on the intracellular ATP level, the primary effect of CC14 seems to be on lipid peroxidation (Recknagel et al, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…Acosta et al (1978) showed with primary monolayer cultures of postnatal rat myocardial cells that complete deprivation of glucose and oxygen caused marked release of cytoplasmic enzymes, and that enzyme leakage was reversed by a change to complete medium and an atmosphere of 20% 02. Hallak and Wilkinson (1976) examined the effects of various inhibitors of glycolysis and uncouplers of oxidative phosphorylation and found that release of intracellular enzymes was controlled by the energy level of the cells. In contrast to the effects of these compounds on enzyme leakage by primary effects on the intracellular ATP level, the primary effect of CC14 seems to be on lipid peroxidation (Recknagel et al, 1982).…”
Section: Discussionmentioning
confidence: 99%
“…However, it is difficult to reconcile with this theory the protective effect exerted by AMP on human erythrocytes (21) and human lymphocytes (8). marked difference in the adenylate kinase ac tivities of the cells of the two species previously reported (20) was not confirmed, however.…”
Section: Discussionmentioning
confidence: 56%
“…Suggestions that the leakage of intracellular enzymes in pathological conditions is due, at least in part, to diminution of the energy content of the cells affected have been sup ported by studies on intact rat muscles (23), chicken muscle slices (5, 13), human erythro cytes (6,8,17,21), and rat lymphocytes (8,19,20). However, it is difficult to reconcile with this theory the protective effect exerted by AMP on human erythrocytes (21) and human lymphocytes (8).…”
Section: Discussionmentioning
confidence: 99%
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“…The lowering of the ATP concentration may lead to a disturbance in the integrity of the plasma membrane of brain cells, resulting in a leakage of intracellular substances in the extracellular fluid (cf. Weed et al (1969), Wilkinson et al Hallak &Wilkinson (1976)).…”
mentioning
confidence: 99%