Adenylate kinase activity in cerebrospinal fluid of schizophrenic and certain other psychiatric symptomatologies

Abstract

Adenylate kinase activity in the cerebrospinal fluid (CSF) was investigated in 29 patients with psychiatric symptomatologies. Such activity was demonstrated in 18 of the 19 individuals with schizophrenic or other psychotic or borderline psychotic symptomatology. No activity was seen in the remaining 10 patients with non-psychotic nervous and/or functional somatic complaints, nor in the 20 persons whose CSF was examined in connection with spinal anaesthesia, nor in four who were treated with neuroleptic drugs on nonpsychiatric indications. The findings are compatible with the assumption that in persons with psychotic or borderline psychotic symptomatology a lowered membrane electrochemical potential may be associated with some of the symptoms exhibited.

Case report: Psychosis associated with hepatitis B

“…Any condition causing cerebral hypoxia will result in less ATP production and a subsequent lowered electrochemical potential of the cellular membranes with leakage of intracellular compounds. Elevated levels of AK has been linked to various forms of CNS pathology such as ischaemia, tumor, and even psychosis [Alm et al, 1979;Vreca et al, 19891.…”

“…Any condition causing cerebral hypoxia will result in less ATP production and a subsequent lowered electrochemical potential of the cellular membranes with leakage of intracellular compounds. Elevated levels of AK has been linked to various forms of CNS pathology such as ischaemia, tumor, and even psychosis [Alm et al, 1979;Vreca et al, 19891. Initially the possibility of a n isoniazid (INH) psychosis was considered, since our patient received INH prophylaxis. The mental symptoms of INH therapy are said to occur a t the time of maximum circulating concentration of the drug and the neurological complications are due to a pyridoxine deficiency [Kucers and Bennet, 1988;Girling, 19821.…”

Isoflurane Inhibits the Na+/K+-ATPase: Comment

“…So, adenylate kinase leaked into the CSF signals neuronal damage. By then, CSF adenylate kinase had already been used to detect brain damage associated with brain tumors, 2 in schizophrenia, 3 in neurologic diseases, 4 after open-heart surgery, 5 in meningoencephalitis, 6 after circulatory arrest, 7 and in hypoxic newborns. 8 I thought, it would be interesting to use this analysis to show that deep isoflurane anesthesia for induced hypotension for orthognathic surgery carries no risk to the brain.…”