“…So, adenylate kinase leaked into the CSF signals neuronal damage. By then, CSF adenylate kinase had already been used to detect brain damage associated with brain tumors, 2 in schizophrenia, 3 in neurologic diseases, 4 after open-heart surgery, 5 in meningoencephalitis, 6 after circulatory arrest, 7 and in hypoxic newborns. 8 I thought, it would be interesting to use this analysis to show that deep isoflurane anesthesia for induced hypotension for orthognathic surgery carries no risk to the brain.…”