Action of Coriandrum sativum L. Essential Oil upon Oral Candida albicans Biofilm Formation

Abstract

The efficacy of extracts and essential oils from Allium tuberosum, Coriandrum sativum, Cymbopogon martini, Cymbopogon winterianus, and Santolina chamaecyparissus was evaluated against Candida spp. isolates from the oral cavity of patients with periodontal disease. The most active oil was fractionated and tested against C. albicans biofilm formation. The oils were obtained by water-distillation and the extracts were prepared with macerated dried plant material. The Minimal Inhibitory Concentration—MIC was determined by the microdilution method. Chemical characterization of oil constituents was performed using Gas Chromatography and Mass Spectrometry (GC-MS). C. sativum activity oil upon cell and biofilm morphology was evaluated by Scanning Electron Microscopy (SEM). The best activities against planktonic Candida spp. were observed for the essential oil and the grouped F8–10 fractions from C. sativum. The crude oil also affected the biofilm formation in C. albicans causing a decrease in the biofilm growth. Chemical analysis of the F8–10 fractions detected as major active compounds, 2-hexen-1-ol, 3-hexen-1-ol and cyclodecane. Standards of these compounds tested grouped provided a stronger activity than the oil suggesting a synergistic action from the major oil constituents. The activity of C. sativum oil demonstrates its potential for a new natural antifungal formulation.

Medicinal plants with antimicrobial activities (part 2): Plant based review

“…2-hexen-1-ol, 3-hexen-1-ol and cyclodecane were determined as the active constituents in the oil [179].…”

In vitro effects of Coriandrum sativum, Tagetes minuta, Alpinia zerumbet and Lantana camara essential oils on Haemonchus contortus

“…A. zerumbet, from the Zingiberaceae family, exhibits antioxidant (ELZAAWELY et al, 2007), antibacterial and antifungal activities (VICTÓRIO et al, 2009). C. sativum, belonging to the Umbelliferae family, has antifungal activity (FURLETTI et al, 2011), nematicidal activity against the phytonematode Bursaphelenchus xylophilus (KIM et al, 2008), and anthelmintic activity on gastrointestinal nematodes (EGUALE et al, 2007).…”

Anti-candida activity by <i>Hymenocallis littoralis</i> extracts for opportunistic oral and genital infection <i>Candida albicans</i>

“…Plant materials such as extracts, essential oils and isolated compounds have been demonstrated to inhibit the growth of bacteria (Erturk, 2006), yeast (Duarte et al, 2005) and filamentous fungi (Fukai et al, 2003) (Furletti, 2011). H. littoralis is a well-known plant for its isolated alkaloids and flavonoid compounds.…”