Action inhibitrice de l'héparine sur le phénomène d'Arthus

Lecomte, Jean; Hugues, J

doi:10.1159/000228114

Cited by 13 publications

(3 citation statements)

References 7 publications

(7 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-inflammatory actions of heparin have also been described. For example, it has been shown to suppress neutrophil function and chemotaxis in vitro (Matzner et al, 1984;Bazzoni et al, 1993), reduce neutrophil migration into the inflamed rat paw (McGovern, 1957) and inhibit increases in vascular permeability in rabbit skin (Lecomte & Hugues, 1954;Carr, 1979). Heparin also appears to diminish the bronchoconstrictor response of sheep to allergic and nonallergic stimuli (Ahmed et al, 1992) and the immediate response to antigen in the skin and lungs of allergic human subjects (Bowler et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

Teixeira

Hellewell

1993

British J Pharmacology

View full text Add to dashboard Cite

1 Heparin is widely used in the treatment of thrombotic disorders and as an aid in surgery. Antiinflammatory effects of heparin have also been described. In this study, we have investigated the effects of locally-injected heparin on the oedema formation and eosinophil accumulation induced by various inflammatory stimuli in guinea-pig skin.2 Heparin dose-dependently suppressed the accumulation of "'In-labelled eosinosphils induced by i.d. injection of zymosan-activated plasma (ZAP). The "'In-eosinophil accumulation induced by other inflammatory stimuli (compound 48/80, platelet activating factor, interleukin-8 and in a passive cutaneous anaphylaxis reaction) was also suppressed by locally-injected heparin. 3 Oedema formation in response to these same stimuli was not altered by the local injection of heparin. 4 Fucoidin, a negatively-charged sulphated algal polymer, had no effect on the "1'In-eosinophil accumulation or oedema formation induced by ZAP. Nevertheless, fucoidin significantly suppressed the oedema formation induced by i.d. injection of cationic protein-containing extracts of Schistosoma mansoni larvae. Heparin also inhibited oedema induced by the extracts, suggesting that both fucoidin and heparin were effectively neutralizing the cationic protein of the extracts to inhibit their oedemainducing activity.5 Thus, heparin significantly inhibited the accumulation of "'In-eosinophils, but not oedema formation, induced by various inflammatory stimuli. This, taken together with the lack of effect of fucoidin, suggests that heparin interferes with the process of eosinophil trafficking by a mechanism that does not depend on neutralisation of the charge of the stimulatory molecules.

show abstract

Section: Introductionmentioning

confidence: 99%

Suppression by intradermal administration of heparin of eosinophil accumulation but not oedema formation in inflammatory reactions in guinea‐pig skin

Teixeira

Hellewell

1993

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…102 , 103, 124, 220 Heparin pretreatment also suppresses anaphylactic shock in sensitized pigeons124 and the Arthus phenomenon in sensitized rabbits. 133 In anaphylactic shock, heparin prevents a decrease in platelets and an increase in 5-hydroxytryptamine in whole blood. 102 , 103 Heparin may act by inhibiting the ability of platelets to absorb or release 5-hydroxytryptamine.…”

Section: Anticomplementary Effect; Treatment Of Hyperimmune Diseasesmentioning

confidence: 99%

Some side effects of heparin, heparinoids, and their antagonists

Coon

Willis

1966

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

show abstract

“…It is further known that heparin prevents several local allergic reactions such as the Schwartzman reaction (Cluff andBerthrong 1953, Good andThomas 1953), and the Arthus phenomenon (Hugues and Lecomte 1954, Gregoire 1946.…”

Section: Stig-arne Johansson Ante Lundberg and Hans-eric Sjobergmentioning

confidence: 99%