Some side effects of heparin, heparinoids, and their antagonists

Coon, William W.; Willis, Park W.

doi:10.1002/cpt196673379

Cited by 26 publications

(8 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, there is some evidence that heparin's high electronegative charge keeps erythrocytes and, perhaps, all other blood cells dispersed [9], probably also during the standstill of perfusion. This effect might even be enhanced by an increase in the negative charge of the endothelium as a result of absorption of heparin [2]. Heparin's additional capability of decreasing blood viscosity [2] may further improve patency in the hepatic microvasculature following cardiac arrest and arterial flushing.…”

Section: Discussionmentioning

confidence: 99%

“…This effect might even be enhanced by an increase in the negative charge of the endothelium as a result of absorption of heparin [2]. Heparin's additional capability of decreasing blood viscosity [2] may further improve patency in the hepatic microvasculature following cardiac arrest and arterial flushing. Table 1 Activities of AST and ALT in 24-h-perfusate of livers harvested after 60 min of cardiac arrest and iv pretreatment with either heparin (300 U/kg; n = 6) or heparin (300 U/kg) and phentolamine (1 mg/kg; n = 7) 10 Mean +_ SEM, * P < 0.05 vs control…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model

Richter

Yamauchi

Minor

et al. 2000

Transplant International

View full text Add to dashboard Cite

Improvement of organ procurement from non-heart-beating donors (NHBDs) could increase the donor organ pool for liver transplantation. Whether anti-coagulative and anti-vasospastic substances can improve hepatic microvascular preservation from NHBDs is unknown. In donor rats which were pretreated with either heparin (n = 6) or heparin combined with phentolamine ( n = 7) 10 min prior to cardiac arrest, the extent and homogeneity of hepatic microvascular reperfusion was assessed at the end of a 60-min period of cardiac arrest using in situ fluorescence microscopy. Non-pretreated animals with cardiac arrest for 60 min served as controls (n = 6). In the non-treated NHBDs, arterial gravity perfusion of 100 cm H,O with HTK-solution led to a hepatic acinar reperfusion of only -22 % with a remarkably diminished sinusoidal density. Application of heparin prior to cardiac arrest resulted in a two-fold, but insignificant increase of acinar perfusion and sinusoidal density with a still considerable heterogeneity of both parameters. Livers of NHBDs that additionally received phentolamine exhibited significantly increased values of both acinar perfusion and sinusoidal density. Phentolamine was found to reduce heterogeneity of organ microperfusion. Thus, our results indicate that the combined application of heparin and phentolamine is a useful additive for optimizing the quality of organs harvested from NHBDs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model

Richter

Yamauchi

Minor

et al. 2000

Transplant International

View full text Add to dashboard Cite

show abstract

“…A quality of heparin which has been known for many years but has attracted little attention is its capacity in vivo to inhibit a number of antigen-antibody reactions in man and laboratory animals. 34 In humans both heparin and PNP have inhibited hemolysis in autoimmune hemolytic anemia. 35 This makes it possible that the preventative action of heparin and PNP in migraine could involve correct-ing a deficit in immunologic function, although other mechanisms certainly cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

Prophylaxis of Migraine with Anionic Polyelectrolytes

Thonnard-Neumann

Bigelow

1988

Headache

View full text Add to dashboard Cite

SYNOPSIS In previous studies on patients with migraine headaches we found that 50% had reduced concentrations of basophils and lymphocytes. Treatment with inhalations of heparin often restored these blood indices to normal and was accompanied by a reduction in migraine headache, We report here data on the long term treatment of 37 migraine patients with inhalations of heparin and with an oral semi‐synthetic heparinoid, Pentosan Polysulfate (PNP). 27 patients responded with a mean improvement in migraine index of 79% and as a group showed significant increases in basophil, total lymphocyte, and in particular T‐cell concentrations. Ten patients whose migraine headaches were related to their menstrual cycles were relatively unresponsive to heparin or PNP. They had a general leukopenia, but basophils were within normal range.

show abstract

“…A great deal o f data has, however, accumulated regarding the multiple effects of heparin [4,5] and it is interesting to speculate on the possible relationship be tween some of the known actions o f heparin and the modifying effect of the drug in proliferative glomerulonephritis. In Masugi nephritis produced in rabbits, the glomerular lesion is significantly attenuated or prevented if the animal is heparinized prior to administration of the anti-kidney serum [13,12,21].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Long Term High Dose Heparin Treatment on the Course of Chronic Proliferative Glomerulonephritis

Cade

Shires

et al. 1971

Nephron

View full text Add to dashboard Cite

18 patients with biopsy proven chronic proliferative glomerulonephritis have been studied, 10 of the 18 received daily subcutaneous injections of depo-heparin until death or for a period of at least 1 year. 8 of the 10 patients so treated demonstrated significant improvement in renal function as measured by serial determination of endogenous creatinine clearance, Addis count, protein permeability index, and renal biopsy. 1 patient with severely impaired function prior to heparin therapy did not improve, but renal function remained stable during the period of treatment. 8 of the 10 control patients were followed adequately for evaluation. Of these 8, 6 demonstrated progressive diminution of renal function, 4 expired in renal failure; in addition, 1 control patient followed too sporadically to include in the study is known to have died of renal failure.

show abstract

Some side effects of heparin, heparinoids, and their antagonists

Cited by 26 publications

References 101 publications

Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model

Heparin and phentolamine combined, rather than heparin alone, improves hepatic microvascular procurement in a non-heart-beating donor rat-model

Prophylaxis of Migraine with Anionic Polyelectrolytes

The Effect of Long Term High Dose Heparin Treatment on the Course of Chronic Proliferative Glomerulonephritis

Contact Info

Product

Resources

About