Actinomycosis Caused by<i>Arachnia propionica</i>: Report of 11 Cases

Brock, Darrell W.; Georg, Lucille K.; Brown, June M.; Hicklin, Martin D.

doi:10.1093/ajcp/59.1.66

Cited by 61 publications

(20 citation statements)

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“…2). This typical appearance was noted by Brock et al 6 On subsequent subculture growth of this actinomycete was extremely slow on solid media, but it was found to grow over a 2-week period in thioglycollate broth. Typical 'bread crumb' colonies were formed in this medium.…”

Section: Microbiological Examinationsupporting

confidence: 76%

Lacrimal canaliculitis due to Arachnia (Actinomyces) propionica.

Seal¹,

McGill²,

Flanagan³

et al. 1981

British Journal of Ophthalmology

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Section: Microbiological Examinationsupporting

confidence: 76%

Lacrimal canaliculitis due to Arachnia (Actinomyces) propionica.

Seal¹,

McGill²,

Flanagan³

et al. 1981

British Journal of Ophthalmology

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“…propionica (7) A. noeslurrdii (5) A. odontolyticus (5) A. bovis (4) (6) A viscosus (15) Ar. propionica (7) A naeslundii (5) A. odontolyticus (5) A. bovis (4) LS 19 7 (31) A. eriksonii (6) L A viscosus (15) Ar propionico (7) A naeslundii (5) of actinomycetes to clin-…”

Section: Resultsunclassified

“…The organism originally described as Acf tinomyces propionicus by Buchanan (25) A eriksonii (6) A. viscosuss (15) Ar propionica (7) A naeslundii (5) A odontolyticus (5) A bovis (4) (30). They summarized both clinical and in vitro experiences reported to that time and concluded that penicillin, in adequate and sometimes massive doses given over an extended period of weeks to months, was the undisputed drug of choice.…”

mentioning

confidence: 99%

Susceptibility of Pathogenic Actinomycetes to Antimicrobial Compounds

Lerner

1974

Antimicrob Agents Chemother

100

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Current interest in antimicrobial susceptibility testing of anaerobic pathogens and recent recognition that actinomycetes other than Actinomyces israelii may cause actinomycosis in man prompted this in vitro survey of 74 strains of actinomycetes, representing seven species. Minimum inhibitory concentrations (MICs) for 24 antimicrobials were determined by inhibition of gross colonial enlargement in semisolid antibiotic agar after incubation at 37 C for 48 h under anaerobic conditions. Erythromycin and rifampin were the most active drugs in vitro (MICs of 0.008 to 0.25 ug/ml), although a small number of non-israelii strains were conspicuously more resistant to the latter (MICs > 0.5 ,g/ml). Penicillin G, cephaloridine, minocycline, and clindamycin were also very active in vitro (MICs of 0.03 to 1.0 ,ug/ml); for a few non-israelii strains the MICs of clindamycin were 2.0 to 8.0 ,ug/ml. MICs of cephalothin, ampicillin, lincomycin, tetracycline, doxycycline, and chloramphenicol were well within a therapeutic range for all strains of A. israelii and most other species, although the MIC of lincomycin against a few non-israelii strains and of tetracycline and doxycycline against the majority of these strains was 2.0 to 8.0 ,g/ml. Oxacillin, dicloxacillin, and cephalexin were less active in vitro, particularly against strains other than A. israelii. Most non-israelii species were not suppressed by 125 ,ug of metronidazole per ml, which concentration inhibited all strains of A. israelii; otherwise, there were no antimicrobial susceptibility differences among the species tested. Aminoglycoside activity was negligible.

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“…Of these three, P. propionicum is the most pathogenic species, causing actinomycosis-like disease. P. propionicum has been isolated from patients with lacrimal canaliculitis, osteomyelitis, brain abscess, endodontic infections, chronic tympanomastoiditis, renal abscess, pulmonary abscess, and cervico-facial actinomycosis (2,4,6,10,21,23,30,33); in one case of chronic granulomatous disease with multiple episodes of chest trauma and microabscesses and granulomatous inflammation in lung tissue (26); and in one case of disseminated actinomycosis with a hepatic abscess (14). This case report represents the first finding of P. propionicum in association with pelvic disease.…”

mentioning

confidence: 99%

“…in this case of an actinomycosis-like disease due to P. propionicum therefore is not unusual. We consider P. propionicum to be the main pathogen, because in this case it is the only isolate that can cause an actinomycosis-like disease (2,4,6,10,14,21,23,26,30,33). The contribution of P. micra and Peptostreptococcus sp.…”

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confidence: 99%

Pelvic Actinomycosis-Like Disease Due to Propionibacterium propionicum after Hysteroscopic Removal of an Intrauterine Device

et al. 2011

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A female patient presented with episodes of fever and pain in the lower right abdomen after hysteroscopic removal of an intrauterine device 2 months earlier. Pelvic actinomycosis originating from a tubo-ovarian abscess was diagnosed with Propionibacterium propionicum, formerly known as Arachnia propionica, as causative agent. CASE REPORTA 38-year-old woman presented at the emergency department with complaints of periodic fever and pain in the lower right abdomen 2 months after hysteroscopic removal of an intrauterine device (IUD). The temperature was 38°C. At gynecological examination, tenderness of the right lower abdomen was noticed with a bulging swelling in the recto-uterine pouch. Laboratory examinations showed a leukocytosis (13.4 ϫ 10 9 /liter; normal value ϭ 4.0 ϫ 10 9 to 10.0 ϫ 10 9 /liter), an elevated C-reactive protein level (129 mg/liter; normal value ϭ 1 to 10 mg/liter), an elevated erythrocyte sedimentation rate (45 mm; normal value ϭ 0 to 25 mm), and a microcytic anemia (hemoglobin [Hb] ϭ 11.4 g/dl; normal value ϭ 12 to 16.1 g/dl), indicating the presence of a chronic infection. An abdominalpelvic ultrasonography showed an enlarged right adnexum measuring 9 cm in diameter with a multilocular circumscribed fluid collection with a small echodense area and a larger transonic area with some free fluid in the recto-uterine pouch (Fig. 1, panel 1, A and B).Pelvic inflammatory disease with a tubo-ovarian abscess was suspected, and antibiotic treatment consisting of doxycycline and metronidazole was administered. There was no clinical improvement after 2 days of treatment, and subsequently vaginal puncture of the abscess was performed. Gram stains of the abscess material showed a few Gram-positive, filamentous rods with possible branching, positive cocci in chains, and many polymorphonuclear leukocytes. Based on the results of the Gram stain, doxycycline was switched to penicillin to treat a possible actinomycosis.After 2 days of incubation, smooth white colonies of branching Gram-positive rods and small colorless colonies of Grampositive cocci were observed on the anaerobic medium, Columbia agar with 5% sheep blood (bioMérieux Benelux B.V., Boxtel, Netherlands). The Gram-positive rods were catalase and oxidase negative, and biochemical evaluation on the basis of the API Rapid ID 32 A test (bioMérieux Benelux B.V., Boxtel, Netherlands) identified the organism as Propionibacterium propionicum, formerly known as Arachnia propionica. The Gram-positive cocci were identified as Parvimonas micra and a Peptostreptococcus species using the same API Rapid ID 32 A test (bioMérieux Benelux B.V., Boxtel, Netherlands). The P. propionicum and Peptostreptococcus species were confirmed with 16S rRNA sequencing, and both showed Ͼ99.9% homology with representatives in GenBank. Sequence analysis of the P. propionicum strain resulted in 1,061 bp of the 5Ј end from the 16S rRNA gene, which was given the GenBank accession number HQ413290. The highest homology was observed with the partial 16S rRNA sequence of P. propionicum w...

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Actinomycosis Caused byArachnia propionica: Report of 11 Cases

Cited by 61 publications

References 0 publications

Lacrimal canaliculitis due to Arachnia (Actinomyces) propionica.

Lacrimal canaliculitis due to Arachnia (Actinomyces) propionica.

Susceptibility of Pathogenic Actinomycetes to Antimicrobial Compounds

Pelvic Actinomycosis-Like Disease Due to Propionibacterium propionicum after Hysteroscopic Removal of an Intrauterine Device

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