Actinomycine, XXI. Antibiotica aus Actinomyceten, XLIII. Actinomycin X<sub>0β</sub>; zur Systematik und Nomenklatur der Actinomycine

Brockmann, Hans; Pampus, Gottfried; Manegold, Jost Henrich

doi:10.1002/cber.19590920610

Cited by 29 publications

(5 citation statements)

References 17 publications

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“…3 ) experiments. Dereplication of these ions using the AntiMarin database matched with actinomycin D and actinomycin X2 and actinomycin X 0β 52 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants

Fernández‐Marín

Mejía

et al. 2017

Sci Rep

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The fungus-growing ant-microbe symbiosis is an ideal system to study chemistry-based microbial interactions due to the wealth of microbial interactions described, and the lack of information on the molecules involved therein. In this study, we employed a combination of MALDI imaging mass spectrometry (MALDI-IMS) and MS/MS molecular networking to study chemistry-based microbial interactions in this system. MALDI IMS was used to visualize the distribution of antimicrobials at the inhibition zone between bacteria associated to the ant Acromyrmex echinatior and the fungal pathogen Escovopsis sp. MS/MS molecular networking was used for the dereplication of compounds found at the inhibition zones. We identified the antibiotics actinomycins D, X2 and X0β, produced by the bacterium Streptomyces CBR38; and the macrolides elaiophylin, efomycin A and efomycin G, produced by the bacterium Streptomyces CBR53.These metabolites were found at the inhibition zones using MALDI IMS and were identified using MS/MS molecular networking. Additionally, three shearinines D, F, and J produced by the fungal pathogen Escovopsis TZ49 were detected. This is the first report of elaiophylins, actinomycin X0β and shearinines in the fungus-growing ant symbiotic system. These results suggest a secondary prophylactic use of these antibiotics by A. echinatior because of their permanent production by the bacteria.

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“…3 ) experiments. Dereplication of these ions using the AntiMarin database matched with actinomycin D and actinomycin X2 and actinomycin X 0β 52 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants

Fernández‐Marín

Mejía

et al. 2017

Sci Rep

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“…This report is an attempt to supply a score card to any interested spectators who may not be familiar with the names, numbers, and positions of the players in the game. It is not expected that any old scores on actinomycin nomenclature (Waksman, Katz, and Vining, 1958;Brockmann, Pampus, and Manegold, 1959) will be settled. We simply wish to give the letter and number designations of the various actinomycins and to indicate which actinomycins may be equivalent entities on the basis of chromatographic, physical, chemical, and biological evidence.…”

mentioning

confidence: 99%

“…In addition, the nature and the sequence of the amino acids in the peptides of an actinomycin molecule will be presented when such information is known. The following symbol, -< (turned in a clockwise direction 900), previously used by Brockmann et al (1959), will be employed by us to denote the actinomycin chromophore (table 1). The forks of the above symbol represent the -NH2 and C=CO groups of the molecule.…”

mentioning

confidence: 99%

Variations on a Theme. The Actinomycins1

Katz¹,

Pugh²

1961

Applied Microbiology

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“…Of these trans-4-hydroxy--proline is most abundant, being found in secondary metabolites such as the echinocandins [2] and actinomycins [3], as well as being an important constituent of collagen. -Proline has been identified as the precursor of the hydroxylated residues in each of these cases [4], and the protocollagen -prolylhydroxylating system has been extensively investigated (for a review see [5]).…”

Section: Introductionmentioning

confidence: 99%

Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis

Lawrence¹,

Sobey²,

Field³

et al. 1996

Biochemical Journal

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Proline 4-hydroxylase is a 2-oxoacid, ferrous-ion-dependent dioxygenase involved in the biosynthesis of the secondary metabolite etamycin. The purification, in low yield, of proline 4-hydroxylase from Streptomyces griseo iridus P8648 to near apparent homogeneity and its initial characterization are reported. In most respects proline 4-hydroxylase is a typical member of the 2-oxoacid-dependent dioxygenase family. It is monomeric (M r approx. 38 000) (by gel filtration on Superdex-G75) and has typically strict requirements for ferrous ion and 2-oxoglutarate. The enzyme was inhibited by aromatic analogues of 2-oxoglutarate. -Proline-uncoupled turnover of 2-

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Actinomycine, XXI. Antibiotica aus Actinomyceten, XLIII. Actinomycin X_0β; zur Systematik und Nomenklatur der Actinomycine

Cited by 29 publications

References 17 publications

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants

Variations on a Theme. The Actinomycins1

Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis

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Actinomycine, XXI. Antibiotica aus Actinomyceten, XLIII. Actinomycin X0β; zur Systematik und Nomenklatur der Actinomycine

Cited by 29 publications

References 17 publications

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants

Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants

Variations on a Theme. The Actinomycins1

Purification and initial characterization of proline 4-hydroxylase from Streptomyces griseoviridus P8648: a 2-oxoacid, ferrous-dependent dioxygenase involved in etamycin biosynthesis

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Product

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Actinomycine, XXI. Antibiotica aus Actinomyceten, XLIII. Actinomycin X_0β; zur Systematik und Nomenklatur der Actinomycine