2021
DOI: 10.1136/bmjopen-2020-039169
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Across-subjects multiple baseline trial of exposure-based cognitive-behavioral therapy for severe irritability: a study protocol

Abstract: IntroductionIrritability is defined as a tendency towards anger in response to frustration. Clinically, impairing irritability is a significant public health problem. There is a need for mechanism-based psychotherapies targeting severe irritability as it manifests in the context of disruptive mood dysregulation disorder (DMDD). This study protocol describes a randomised multiple baseline design testing the preliminary efficacy of a new treatment, exposure-based cognitive-behavioral therapy for severe irritabil… Show more

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Cited by 16 publications
(11 citation statements)
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“…In Brazil, the most prevalent problem was irritability, with almost half of the participants reporting frequent irritability. It is interesting to note that irritability is defined as an emotional state that tends to lead to anger in response to frustration [47]. In the context of the COVID-19 pandemic, irritability is likely to reflect the frustration of not being able to enjoy routine and amusement activities.…”
Section: Discussionmentioning
confidence: 99%
“…In Brazil, the most prevalent problem was irritability, with almost half of the participants reporting frequent irritability. It is interesting to note that irritability is defined as an emotional state that tends to lead to anger in response to frustration [47]. In the context of the COVID-19 pandemic, irritability is likely to reflect the frustration of not being able to enjoy routine and amusement activities.…”
Section: Discussionmentioning
confidence: 99%
“…Recently developed treatments include the Unified Protocol for Transdiagnostic Treatment, CBT and integrated therapy with PMT [64][65][66][67][68]. Innovations in CBT targeting severe irritability, anger and aggression include behavioural exposure to frustrative nonrewarding and threatening stimuli [69]. Other treatments have expanded upon applications of emotion-coaching to improve child emotion regulation.…”
Section: Targeting Core Dysfunctionsmentioning
confidence: 99%
“…Despite this, treatments for irritability are limited. One promising treatment approach, based on our neurobiologically informed understanding of irritability, is exposure to anger-inducing events [ 73 ]. Preliminary evidence demonstrates the efficacy of exposure to anger-inducing events (as part of exposure-based cognitive behavioral therapy, CBT) as a treatment for irritability [ 69 ].…”
Section: Introductionmentioning
confidence: 99%
“…First, a substantial portion of youth do not sufficiently benefit from evidence-based treatments like CBT [ 26 ]. Furthermore, there is a paucity of CBT studies that target anger in youth from which to derive an understanding of clinical efficacy [ 31 , 48 , 69 , 73 , 94 ]. Approximately 22% to 50% of youth undergoing CBT for anxiety disorders or posttraumatic stress—both of which include irritability as a diagnostic symptom—do not respond or do not reach remission [ 46 , 51 , 57 , 79 , 88 ].…”
Section: Introductionmentioning
confidence: 99%