Acrokeratosis paraneoplastica of Bazex

Abstract

squamous cell carcinomas, both adenocarcinoma"l Ba&ed on Bazex disease is one of the rarer cutaneous paraneoand carcinoid tumourse have been reported. case presented plastic syndromes. It is characterized by psoriasiform In many patients the severity of the cutaneous to Section of changes on the digits, and in soinw patients spread changes parallel the extent ofthe tumour, but in some DerMaytlo991, to the ears, nose and in later stages to the limbs and case the cutaneous changes can either precede3'9 or trunk. The associated malignancyis. typicallya follow5 the-development Of the tumour-by many squamous cell carcinoma of the upper aerodigestive months. In those cases where the tumour has been tract. We review the literature regarding acrokeratosis treatable the skin lesions have improved as the paraneoplastica of Bazex and report three cases which 'tumour regressed, only to recur with tumour relapse. illustrate both the typical and some of the less Local treatment to the skin usuBally fails to clear the common changes that are seen in-the condition. lesions. Recent reports suggest that there may be a good response to systemic retinoids514.